BBO-8520, KRAS G12C 抑制剂
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- CAS号:
- 2893809-51-1
- 英文名:
- Benzo[b]thiophene-3-carbonitrile, 2-amino-4-[4-[(2S,5R)-2,5-dimethyl-4-(1-oxo-2-propen-1-yl)-1-piperazinyl]-8-fluoro-2-[[(2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl]methoxy]-6-(trifluoromethyl)-7-quinazolinyl]-7-fluoro-, (4S)-
- 英文别名:
- 4-((R)-4-((2S,5R)-4-acryloyl-2,5-dimethylpiperazin-1-yl)-8-fluoro-2-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-6-(trifluoromethyl)quinazolin-7-yl)-2-amino-7-fluorobenzo[b]thiophene;4-((R)-4-((2S,5R)-4-acryloyl-2,5-dimethylpiperazin-1-yl)-8-fluoro-2-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-6-(trifluoromethyl)quinazolin-7-yl)-2-amino-7-fluorobenzo[b]thiophene-3-carbonitrile;Benzo[b]thiophene-3-carbonitrile, 2-amino-4-[4-[(2S,5R)-2,5-dimethyl-4-(1-oxo-2-propen-1-yl)-1-piperazinyl]-8-fluoro-2-[[(2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl]methoxy]-6-(trifluoromethyl)-7-quinazolinyl]-7-fluoro-, (4S)-
- 中文名:
- BBO-8520, KRAS G12C 抑制剂
- 中文别名:
- 化合物 BBO-8520;BBO-8520, KRAS G12C 抑制剂
- CBNumber:
- CB614033104
- 分子式:
- C35H33F6N7O2S
- 分子量:
- 729.74
- MOL File:
- 2893809-51-1.mol
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BBO-8520, KRAS G12C 抑制剂化学性质
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沸点:
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855.8±75.0 °C(predicted)
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密度:
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1.50±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
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形态:
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Solid
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酸度系数(pKa):
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8.93±0.70(predicted)
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颜色:
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White to off-white
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InChIKey:
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RIVFEDYNLHJKEZ-UHFFFAOYSA-N
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SMILES:
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C(C12CCCN1CC(C2)F)OC1=NC2C(=C(C3C=CC(=C4SC(=C(C=34)C#N)N)F)C(=CC=2C(N2CC(N(CC2C)C(=O)C=C)C)=N1)C(F)(F)F)F
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BBO-8520, KRAS G12C 抑制剂性质、用途与生产工艺
BBO-8520, KRAS G12C 抑制剂 是靶向 KRASG12C 的直接小分子共价抑制剂，有较高的口服利用度，同时具有 KRASG12C (OFF) 抑制剂特性和阻断 KRAS G12C (ON) 信号的作用。BBO-8520 通过将 GTP 结合蛋白来抑制 KRASG12C (ON)，从而抑制细胞增殖。BBO-8520 也能快速且完全阻断 RAS-RAF1 相互作用，使 KRASG12C 回到非活性 (OFF) 状态。
BBO-8520, KRAS G12C 抑制剂
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上游原料
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BBO-8520, KRAS G12C 抑制剂
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2893809-51-1, BBO-8520, KRAS G12C 抑制剂 相关搜索:
- BBO-8520
- 抗肿瘤小分子
- 抑制剂
- 有机含氮化合物
- 化合物 BBO-8520
- BBO-8520, KRAS G12C 抑制剂
- 2893809-51-1
- 4-((R)-4-((2S,5R)-4-acryloyl-2,5-dimethylpiperazin-1-yl)-8-fluoro-2-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-6-(trifluoromethyl)quinazolin-7-yl)-2-amino-7-fluorobenzo[b]thiophene-3-carbonitrile
- 4-((R)-4-((2S,5R)-4-acryloyl-2,5-dimethylpiperazin-1-yl)-8-fluoro-2-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-6-(trifluoromethyl)quinazolin-7-yl)-2-amino-7-fluorobenzo[b]thiophene
- Benzo[b]thiophene-3-carbonitrile, 2-amino-4-[4-[(2S,5R)-2,5-dimethyl-4-(1-oxo-2-propen-1-yl)-1-piperazinyl]-8-fluoro-2-[[(2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl]methoxy]-6-(trifluoromethyl)-7-quinazolinyl]-7-fluoro-, (4S)-