6-甲基-2-氯异烟酸乙酯
|
|
|
- CAS号:
- 3998-88-7
- 英文名:
- Ethyl 2-chloro-6-methylpyridine-4-carboxylate, 97%
- 英文别名:
- Ethyl 2-chloro-6-methyl-4-pyridinecarboxylate;2-Chloro-6-methylisonicotinic Acid Ethyl Ester;Ethyl 2-chloro-6-methylpyridine-4-carboxylate, 97%;Ethyl 2-chloro-6-methylpyridine-4-carboxylate, 97%;2-Chloro-6-methylpyridine-4-carboxylic acid ethyl ester;4-Pyridinecarboxylic acid, 2-chloro-6-Methyl-, ethyl ester;JR-14076, Ethyl 2-chloro-6-methylpyridine-4-carboxylate, 97%
- 中文名:
- 6-甲基-2-氯异烟酸乙酯
- 中文别名:
- 2-氯-6-甲基异烟酸乙酯;2-氯-6-甲基吡啶-4-羧酸乙酯;2-氯-6-甲基-4-吡啶甲酸乙酯;6-甲基-2-氯异烟酸乙酯,97%;2-氯-6-甲基吡啶-4-甲酸乙酯
- CBNumber:
- CB61569634
- 分子式:
- C9H10ClNO2
- 分子量:
- 199.63
- MOL File:
- 3998-88-7.mol
|
|
|
6-甲基-2-氯异烟酸乙酯化学性质
-
熔点:
-
65-67°C
-
|
-
沸点:
-
107°C/1.5mm
-
|
-
密度:
-
1?+-.0.06 g/cm3(Predicted)
-
|
-
闪点:
-
107°C/1.5mm
-
|
-
储存条件:
-
Inert atmosphere,Room Temperature
-
|
-
溶解度:
-
soluble in Methanol
-
|
-
酸度系数(pKa):
-
-0.14±0.10(Predicted)
-
|
-
形态:
-
powder to crystal
-
|
-
颜色:
-
White to Almost white
-
|
6-甲基-2-氯异烟酸乙酯性质、用途与生产工艺
生产方法
步骤1：2-氯-6-甲基异烟酸乙酯（97）的合成。 在0℃下，向搅拌的2-氯-6-甲基吡啶-4-羧酸（7.0g，40.79mmol）的乙醇（70mL）溶液中逐滴加入浓硫酸（2mL）。随后，将反应混合物加热至80℃并保持12小时。反应完成后，将混合物冷却至室温，并在真空下浓缩以去除溶剂。将浓缩后的残余物用乙酸乙酯稀释，依次用水、碳酸氢钠溶液和饱和氯化钠水溶液洗涤。分离有机层，用无水硫酸钠干燥，过滤后浓缩，得到2-氯-6-甲基异烟酸乙酯（97）（7g，收率86%）为白色固体。
参考文献：
[1] Patent: US2010/249071, 2010, A1. Location in patent: Page/Page column 63-64
[2] Patent: WO2008/29371, 2008, A1. Location in patent: Page/Page column 41
[3] Patent: WO2009/24905, 2009, A1. Location in patent: Page/Page column 38-39; 49
[4] Patent: US2010/63108, 2010, A1. Location in patent: Page/Page column 16
[5] Patent: US2011/46170, 2011, A1. Location in patent: Page/Page column 17
6-甲基-2-氯异烟酸乙酯
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2025/05/22 | XW02399888704 | 2-氯-6-甲基吡啶-4-羧酸乙酯 | 3998-88-7 | 10G | 512元 |
| 2025/05/22 | E1262 | 2-氯-6-甲基异烟酸乙酯
Ethyl 2-Chloro-6-methylisonicotinate | 3998-88-7 | 1g | 170元 |
3998-88-7, 6-甲基-2-氯异烟酸乙酯 相关搜索:
- 医用原料
- 高端化学
- 其它杂环
- 2-氯-6-甲基吡啶-4-羧酸乙酯
- 2-氯-6-甲基-4-吡啶甲酸乙酯
- 6-甲基-2-氯异烟酸乙酯,97%
- 2-氯-6-甲基吡啶-4-甲酸乙酯
- 2-氯-6-甲基异烟酸乙酯
- 3998-88-7
- Ethyl 2-chloro-6-methylpyridine-4-carboxylate, 97%
- Ethyl 2-chloro-6-methyl-4-pyridinecarboxylate
- 2-Chloro-6-methylisonicotinic Acid Ethyl Ester
- JR-14076, Ethyl 2-chloro-6-methylpyridine-4-carboxylate, 97%
- 2-Chloro-6-methylpyridine-4-carboxylic acid ethyl ester
- 4-Pyridinecarboxylic acid, 2-chloro-6-Methyl-, ethyl ester
- Ethyl 2-chloro-6-methylpyridine-4-carboxylate, 97%