保护-2'-脱氧尿苷

保护-2'-脱氧尿苷性质、用途与生产工艺

概述

生产方法 

951-78-0

40615-36-9

23669-79-6

向1-((2R,4S,5R)-4-羟基-5-(羟甲基)四氢呋喃-2-基)嘧啶-2,4(1H,3H)-二酮（22.80g，99.91mmol）的无水吡啶（200mL）溶液中加入4,4'-双甲氧基三苯甲基氯（37.24g，109.90mmol），并将混合物在25℃下搅拌12小时。反应完成后，用饱和NaHCO3/NH4Cl溶液（200mL）淬灭反应，随后用乙酸乙酯（3×200mL）萃取。合并有机层，用盐水（2×100mL）洗涤，无水Na2SO4干燥，减压浓缩。残余物通过柱色谱（石油醚：乙酸乙酯，2：1至0：1）纯化，得到目标产物1-((2R,4S,5R)-5-((双(4-甲氧基苯基)(苯基)甲氧基)甲基)-4-羟基四氢呋喃-2-基)嘧啶-2,4(1H,3H)-二酮（43.00g，72.94mmol），为黄色泡沫。

参考文献：

[1] Bioorganic and Medicinal Chemistry, 1996, vol. 4, # 10, p. 1649 - 1658

[2] Organic letters, 2003, vol. 5, # 6, p. 917 - 919

[3] Journal of the American Chemical Society, 2001, vol. 123, # 15, p. 3405 - 3411

[4] Chemical Research in Toxicology, 2006, vol. 19, # 7, p. 968 - 976

[5] Nucleic Acids Research, 2015, vol. 43, # 11, p. 5275 - 5283

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23669-79-6, 保护-2'-脱氧尿苷 相关搜索:

• 化工中间体
• 核苷
• 医用原料
• 抑制剂
• 其他生化试剂
• Nucleoside Analogs
• Nucleosides, Nucleotides, Oligonucleotides
• BioChemical
• Biochemicals and Reagents
• 5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine
• 5'-O-DMT-DU
• 1-((2R,4S,5R)-5-((双(4-甲氧基苯基)(苯基)甲氧基)甲基)-4-羟基四氢呋喃-2-基)嘧啶-2,4(1H,3H)-二酮
• 5'-O-DMT-2'-脱氧尿苷上DMT
• 1-((2R,4S,5R)-5-((BIS(4-METHOXYPHENYL)(PHENYL)METHOXY)METHYL)-4-HYDROXYTETRAHYDROFURAN-2-YL)PYRIMIDINE-2,4(1H,3H)-DIONE
• 5'-O-DMT-2'-脱氧尿苷
• 5'-DMT-2'-脱氧尿苷
• DMT保护性脱氧尿苷
• 5'-O-(4,4'-二甲氧三苯甲基)-2'-脱氧尿苷
• 5'-O-(4,4'-二甲氧基三苯甲基)-2'-脱氧尿苷
• 5'-O-(4,4'-二甲氧基三苯基甲基)-2'-脱氧尿苷
• 保护-2'-脱氧尿苷
• 保护-2'-脱氧尿甙
• DMT-脱氧尿苷
• 5'-O-[双(4-甲氧基苯基)苄基]-2'-脱氧尿苷
• 23669-79-6
• 5′-O-(4,4′-Dimethoxytrityl)-2′-deoxyuridine, CAS 23669-79-6
• 5’-O-DMTr-2’-deoxyuridine
• 5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine
• 5’-O-DMTr-dU
• 1-((2S,4R,5S)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxytetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
• 5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine, 98%,
• 5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine USP/EP/BP
• 5'-O-DMT-dU
• Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-
• DMT-2'-dU
• 5'-DMT-2'-deoxyuridine
• DMT-DEOXYURIDINE
• 5'-O-DMT-2'-DEOXYURIDINE
• 5'-O-[Bis(4-methoxyphenyl)benzyl]-2'-deoxyuridine
• 5'-DMT-dU
• 2'-Deoxy-5'-O-DMT-uridine
• 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-deoxyuridine
• 2'-Deoxy-5'-O-(4,4'-dimethoxytrityl)uridine
• 5''-O-(4,4''-DIMETHOXYTRITYL)-2''-DEOXYURIDINE 99%
• dmt-du
• 5'-O-Dimethylterephthale-2'-deoxyuridine