5-IODO-2,6-DIMETHYL-PYRIMIDIN-4-OL
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- CAS号:
- 83410-37-1
- 英文名:
- 2,6-DIMETHYL-5-IODO-4(3H)-PYRIMIDONE
- 英文别名:
- 2,6-DIMETHYL-5-IODO-4(3H)-PYRIMIDONE;5-iodo-2,6-dimethyl-4(3H)-Pyrimidinone;5-Iodo-2,6-diMethyl-1H-pyriMidin-4-one;5-Iodo-2,6-dimethylpyrimidin-4(3h)-one;4(3H)-Pyrimidinone, 5-iodo-2,6-dimethyl-;5-iodo-2,6-dimethyl-4-pyrimidinol(SALTDATA: FREE)
- 中文名:
- 5-IODO-2,6-DIMETHYL-PYRIMIDIN-4-OL
- 中文别名:
- 5-碘-2,6-二甲基嘧啶-4-醇;5-碘-2,6-二甲基嘧啶-4(3H)-酮
- CBNumber:
- CB7726358
- 分子式:
- C6H7IN2O
- 分子量:
- 250.04
- MOL File:
- 83410-37-1.mol
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5-IODO-2,6-DIMETHYL-PYRIMIDIN-4-OL化学性质
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熔点:
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196-199 °C
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沸点:
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254.9±43.0 °C(Predicted)
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密度:
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2.03±0.1 g/cm3(Predicted)
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储存条件:
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2-8°C(protect from light)
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酸度系数(pKa):
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8.33±0.50(Predicted)
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5-IODO-2,6-DIMETHYL-PYRIMIDIN-4-OL性质、用途与生产工艺
生产方法
步骤A：将2,6-二甲基嘧啶-4-醇（5.0 g，40 mmol）溶解于氢氧化钠水溶液（50 mL，1 M，50 mmol）中。随后向该溶液中加入碘（10.2 g，40 mmol）。将反应混合物缓慢升温至80℃并持续搅拌2小时。反应完成后，将混合物冷却至室温，并用乙酸调节pH值至约6。此时，反应混合物中出现沉淀，通过过滤收集沉淀物。所得固体用去离子水洗涤，干燥后得到目标产物5-碘-2,6-二甲基嘧啶-4-醇（6.51 g，收率65%）。质谱分析显示m/z 251.2 [M + H]+。
参考文献：
[1] Patent: US9617268, 2017, B2. Location in patent: Page/Page column 398
[2] Journal of Medicinal Chemistry, 1998, vol. 41, # 22, p. 4251 - 4260
[3] Tetrahedron, 2007, vol. 63, # 9, p. 1931 - 1936
[4] Patent: US5466692, 1995, A
[5] Patent: US2012/95031, 2012, A1. Location in patent: Page/Page column 160
5-IODO-2,6-DIMETHYL-PYRIMIDIN-4-OL
上下游产品信息
上游原料
下游产品
5-IODO-2,6-DIMETHYL-PYRIMIDIN-4-OL
生产厂家
83410-37-1, 5-IODO-2,6-DIMETHYL-PYRIMIDIN-4-OL 相关搜索:
- C6H7IN2O
- 5-碘-2,6-二甲基嘧啶-4(3H)-酮
- 5-碘-2,6-二甲基嘧啶-4-醇
- 83410-37-1
- 5-Iodo-2,6-dimethylpyrimidin-4(3h)-one
- 4(3H)-Pyrimidinone, 5-iodo-2,6-dimethyl-
- 5-iodo-2,6-dimethyl-4(3H)-Pyrimidinone
- 5-Iodo-2,6-diMethyl-1H-pyriMidin-4-one
- 5-iodo-2,6-dimethyl-4-pyrimidinol(SALTDATA: FREE)
- 2,6-DIMETHYL-5-IODO-4(3H)-PYRIMIDONE