5-[[5-(4-氟-2-羟基苯基)-2-呋喃基]亚甲基]-2,4-噻唑烷二酮

5-[[5-(4-氟-2-羟基苯基)-2-呋喃基]亚甲基]-2,4-噻唑烷二酮性质、用途与生产工艺

生物活性

AS-252424是一种新型，有效的PI3Kγ抑制剂，IC50为30 nM，作用于PI3Kγ比作用于PI3Kα选择性高30倍，对PI3Kδ/β具有低的抑制活性。

体外研究

AS-252424 is a furan-2-ylmethylene thiazolidinedione as a selective ATP-competitive PI3Kγ inhibitor with IC50 with 33 nM. AS-252424 shows reduced potency on PI3Kα with an IC50 with 935 nM. When screening against 80 different Ser/Thr and Tyr kinases, AS-252424 doesn't show significant inhibit towards any of them at 10 μM except for CK2. AS-252424 inhibits C5a-mediated PKB/Akt phosphorylation in a concentration- dependent manner with submicromolar or low-micromolar IC50 value. AS-252424 inhibits MCP-1-mediated chemotaxis in wild-type primary monocytes in a concentration-dependent manner with an IC50 value of 52 μM, as well as in the monocytic cell line THP-1 with an IC50 value of 53 μM. AS252424 specifically blocks proliferation in the pancreatic cancer cell lines HPAF and Capan1, as assessed by cell counting. A recent research indicates 100 nM of AS-252424 significantly reduces [Ca²⁺]i, I_Ca and Ca²⁺ transients in HL-1 cardiomyocytes.

体内研究

Oral administration of AS-252424 at 10 mg/kg results in moderate reduction of neutrophil recruitment (35%), almost matching the result observed in PI3Kγ-deficient mice.

靶点

PI3Kα 935 nM (IC 50 )

PI3Kγ 30 nM (IC 50 )

PI3Kδ 20 μM (IC 50 )

PI3Kβ 20 μM (IC 50 )

5-[[5-(4-氟-2-羟基苯基)-2-呋喃基]亚甲基]-2,4-噻唑烷二酮 上下游产品信息

上游原料

下游产品

5-[[5-(4-氟-2-羟基苯基)-2-呋喃基]亚甲基]-2,4-噻唑烷二酮 试剂级价格

更新日期	产品编号	产品名称	CAS编号	包装	价格
2025/05/22	HY-13532	5-[[5-(4-氟-2-羟基苯基)-2-呋喃基]亚甲基]-2,4-噻唑烷二酮 AS-252424	900515-16-4	1 mg	350元
2025/05/22	HY-13532	5-[[5-(4-氟-2-羟基苯基)-2-呋喃基]亚甲基]-2,4-噻唑烷二酮 AS-252424	900515-16-4	5mg	770元

5-[[5-(4-氟-2-羟基苯基)-2-呋喃基]亚甲基]-2,4-噻唑烷二酮 生产厂家

 

900515-16-4, 5-[[5-(4-氟-2-羟基苯基)-2-呋喃基]亚甲基]-2,4-噻唑烷二酮 相关搜索:

• A phosphoinositide 3-kinase PI3-kinase p110γ inhibitor.
• Phosphoinositide 3-kinase PI3-kinase p110γ inhibitor.
• PI3K
• mTOR
• Akt
• Inhibitors
• 信号转导通路激酶抑制剂
• 抑制剂
• 合成有机化合物配体
• 细胞生物学试剂
• 小分子抑制剂，天然产物
• C14H8FNO4S
• AS-252424 试剂
• 900515-16-4;AS-252424
• AS-252424 ,S2671
• AS-252424 试剂
• (Z)-5-((5-(4-氟-2-羟基苯基)呋喃-2-基)亚甲基)噻唑烷-2,4-二酮
• 化合物AS-252424,10 MM DMSO 溶液
• AS-252424,PI3KGAMMA抑制剂
• AS-252424,PI3KΓ抑制剂
• (5Z)-5-[[5-(4-氟-2-羟基苯基)-2-呋喃基]亚甲基]-2,4-噻唑烷二酮
• 化合物AS-252424
• PI3KΓ抑制剂(AS-252424)
• 5-[[5-(4-氟-2-羟基苯基)-2-呋喃基]亚甲基]-2,4-噻唑烷二酮
• 5-[[5-(4-氟-2-羟基苯基)-2-呋喃基]亚甲基]-2,4-噻唑烷二酮 2MG
• 900515-16-4
• AS-252424 ，S2671
• AS-252424, 10 mM in DMSO
• AS-252424, PI3Kgamma inhibitor
• S-252424
• AS-252424cas
• 5-[[5-(4-Fluoro-2-hydroxyphenyl)-2-furanyl]methylene]-2,4-thiazolidinedione USP/EP/BP
• (5Z)-5-{[5-(4-Fluoro-2-hydroxyphenyl)furan-2-yl]methylidene}-1,3-thiazolidine-2,4-dione
• 2,4-Thiazolidinedione, 5-[[5-(4-fluoro-2-hydroxyphenyl)-2-furanyl]methylene]-, (5Z)-
• CS-182
• (5Z)-5-[[5-(4-Fluoro-2-hydroxyphenyl)-2-furanyl]methylene]-2,4-thiazolidinedione
• AS-252424;AS 252424
• AS 252424 5-[[5-(4-Fluoro-2-hydroxyphenyl)-2-furanyl]methylene]-2,4-thiazolidinedione
• (Z)-5-((5-(4-fluoro-2-hydroxyphenyl)furan-2-yl)methylene)thiazolidine-2,4-dione
• (E)-5-((5-(4-fluoro-2-hydroxyphenyl)furan-2-yl)Methylene)thiazolidine-2,4-dione
• AS-252424
• 5-[[5-(4-Fluoro-2-hydroxyphenyl)-2-furanyl]methylene]-2,4-thiazolidinedione