(+)使君子氨酸
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- CAS号:
- 52809-07-1
- 英文名:
- QUISQUALIC ACID
- 英文别名:
- QUISQUALATE;QUISQUALIC ACID;L-QUISQUALIC ACID;(+)-QuisqualicAci;Quisqualinic acid;()-QUISQUALIC ACID;(+)-QUISQUALIC ACID;L(+)-QUISQUALIC ACID;Quisqualic acid (7CI);QUISQUALIC ACID USP/EP/BP
- 中文名:
- (+)使君子氨酸
- 中文别名:
- 使君子酸;使君子氨酸;L-使君子氨酸;(+)使君子氨酸;(+)使君子氨酸;异喹啉酸(MM/ML);(+)-QUISQUALIC ACID;Quisqualic acid #天然产物 HY-12597;Quisqualic acid #天然产物 HY-12597;Β-(3,5-二氧代-1,2,4-氧杂重氮烷-2-基)-L-丙氨酸
- CBNumber:
- CB9198500
- 分子式:
- C5H7N3O5
- 分子量:
- 189.13
- MOL File:
- 52809-07-1.mol
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(+)使君子氨酸化学性质
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熔点:
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185-187°C dec.
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比旋光度:
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D20 +17.0° (c = 2.0 in 6M HCl)
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沸点:
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324.36°C (rough estimate)
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密度:
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1.6649 (rough estimate)
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折射率:
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1.6190 (estimate)
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储存条件:
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2-8°C
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溶解度:
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NH4OH 1 M: 20 mg/mL, clear, colorless
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酸度系数(pKa):
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2.12±0.10(Predicted)
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形态:
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powder
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颜色:
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white to off-white
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水溶解性:
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Soluble in ethanol, water. Insoluble in organic solvents.
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Merck:
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13,8177
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BRN:
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1078734
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稳定性:
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Stable. Incompatible with strong oxidizing agents.
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InChI:
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InChI=1/C5H7N3O5/c6-2(3(9)10)1-8-4(11)7-5(12)13-8/h2H,1,6H2,(H,9,10)(H,7,11,12)/t2-/s3
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InChIKey:
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ASNFTDCKZKHJSW-NVFNTWQMNA-N
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SMILES:
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N1(C[C@H](N)C(=O)O)OC(=O)NC1=O |&1:2,r|
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(+)使君子氨酸性质、用途与生产工艺
Quisqualic acid (L-Quisqualic acid) 是一种天然的谷氨酸类似物，是一种有效的，非选择性的兴奋性氨基酸 (EAA) 的两个亚型子集 (iGluR 和 mGluR) 激动剂，对 mGluR1R 的 EC50 为 45 nM，Kd 值为 10 nM。Quisqualic acid 是从藜芦的果实中分离出来的。
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mGluR1R
45 nM (EC
50
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mGluR1R
10 nM (Ki)
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mGluR2R
108 μM (IC
50
)
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mGluR2R
113 μM (Ki)
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mGluR4R
593 μM (IC
50
)
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mGluR4R
112 μM (Ki)
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Quisqualic acid is an agonist of AMPA and metabotropic glutamate receptors. Quisqualic acid activates mGluR2R (EC
50
=108 μM; K
i
=113 μM) and mGluR4R (EC
50
=593 μM; K
i
=112 μM).
用途
本品钾盐有明显的驱除人体肠内蛔虫的作用，排虫率达82%。其对蛲虫的排虫率较蛔虫低，对钩虫、绦虫等肠寄生虫无明显作用。对脊神经的刺激作用大于L-谷氨酸钠，拮抗谷氨酸能竞争中枢神经元的谷氨酸受体。
(+)使君子氨酸
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2025/05/22 | HY-12597 | (+)使君子氨酸
Quisqualic acid | 52809-07-1 | 1 mg | 550元 |
| 2025/05/22 | HY-12597 | (+)使君子氨酸
Quisqualic acid | 52809-07-1 | 5mg | 1500元 |
(+)使君子氨酸
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52809-07-1, (+)使君子氨酸 相关搜索:
- Glutamate receptor
- Neurochemicals
- Amino Acids & Derivatives
- Amino Acids 13C, 2H, 15N
- Glutamate
- Heterocycles
- 标准品
- 氨基酸
- 合成
- 中草药成分
- Ion Channels
- Ionotropic Glutamate Receptor Modulators
- I - Z
- Ligand-Gated Ion Channels
- Modified Amino Acids
- Cell Biology
- Cell Signaling and Neuroscience
- BioChemical
- Biochemicals and Reagents
- Amino Acids and Peptides
- C5H7N3O5
- (+)使君子氨酸
- Quisqualic acid #天然产物 HY-12597
- Quisqualic acid #天然产物 HY-12597
- 异喹啉酸(MM/ML)
- QUISQUALIC ACID (MM/ML),GROUP I MGLU激动剂
- QUISQUALIC ACID,GROUP I MGLU激动剂. AMPA激动剂.
- (S)-2-氨基-3-(3,5-二氧代-1,2,4-恶二唑烷-2-基)丙酸
- (+)-QUISQUALIC ACID
- L-使君子氨酸
- Β-(3,5-二氧代-1,2,4-氧杂重氮烷-2-基)-L-丙氨酸
- 使君子酸
- 使君子氨酸
- (+)使君子氨酸
- 52809-07-1
- Quisqualic acid (mM/ml), group I mGlu agonist
- Quisqualic acid, group I mGlu agonist. AMPA agonist.
- Quisqualic acid (7CI)
- Quisqualinic acid
- QUISQUALIC ACID USP/EP/BP
- (+)-QuisqualicAci
- 1,2,4-Oxadiazolidine-2-propanoic acid, α-amino-3,5-dioxo-, (αS)-
- ()-QUISQUALIC ACID
- 1,2,4-Oxadiazolidine-2-propanoicacid, a-aMino-3,5-dioxo-, (aS)-
- (S)-2-aMino-3-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl)propanoic acid
- Quisqualic acid,β-(3,5-Dioxo-1,2,4-oxadiazolidin-2-yl)-L-alanine, 3-(3,5-Dioxo-1,2,4-oxadiazolidin-2-yl)-L-alanine
- (αS)-α-Amino-3,5-dioxotetrahydro-1,2,4-oxadiazole-2-propionic acid
- (αS)-α-Amino-3,5-dioxo-1,2,4-oxadiazolidine-2-propanoic acid
- (S)-2-Amino-3-(3,5-dioxotetrahydro-1,2,4-oxadiazole-2-yl)propionic acid
- β-(3,5-Dioxo-1,2,4-oxadiazolidin-2-yl)-L-alanine, 3-(3,5-Dioxo-1,2,4-oxadiazolidin-2-yl)-L-alanine
- L-(+)-α-Amino-3,5-dioxo-1,2,4-oxadiazolidine-2-propanoic Acid
- QUISQUALATE
- β-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl)-l-alanine
- L-(+)-a-Amino-3,5-Dioxo-1,2,4-oxadiazolidine-2-pro
- QUISQUALIC ACID
- (+)-QUISQUALIC ACID
- BETA-(3,5-DIOXO-1,2,4-OXADIZOLIDIN-2-YL)-L-ALANINE
- BETA-[3,5-DIOXO-1,2,4-OXADIAZOLIDIN-2-YL]-L-ALANINE