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Ramipril

Ramipril Struktur
87333-19-5
CAS-Nr.
87333-19-5
Englisch Name:
Ramipril
Synonyma:
ALTACE;RaMipril API;Ramipri;Triatec;TRITACE;(2s-(1(r*(r*)),2-alpha,3a-beta,6a-beta))-henylpropyl)amino)-1-oxopropyl;2-[[1-(2-ethoxycarbonyl-3,3a,4,5,6,6a-hexahydro-2H-cyclopenta[b]pyrrol-1-yl)-1-oxopropan-2-yl]amino]-4-phenylbutanoic acid;DELIX;RAMACE;Trimce
CBNumber:
CB0249104
Summenformel:
C23H32N2O5
Molgewicht:
416.51
MOL-Datei:
87333-19-5.mol
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Ramipril Eigenschaften

Schmelzpunkt:
106-108°C
alpha 
D24 +33.2° (c = 1 in 0.1N ethanolic HCl)
Siedepunkt:
616.2±55.0 °C(Predicted)
Dichte
1.200±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
Löslichkeit
DMSO: ~18mg/mL
pka
pKa 3.30±0.01(H2O t = 25.0 I = 0.15 (KCl)) (Uncertain);5.75±0.00(H2O t = 25.0 I = 0.15 (KCl)) (Uncertain)
Aggregatzustand
powder
Farbe
white
Biologische Quelle
synthetic (organic)
BCS Class
1
InChIKey
HDACQVRGBOVJII-JBDAPHQKSA-N
SMILES
N1(C(=O)[C@@H](N[C@H](C(OCC)=O)CCC2=CC=CC=C2)C)[C@H](C(O)=O)C[C@]2([H])CCC[C@]12[H]
CAS Datenbank
87333-19-5(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher Xi
R-Sätze: 36/38
S-Sätze: 26-37/39
WGK Germany  2
RTECS-Nr. GY5879600
HS Code  2933995300
Speicherklasse 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
Hazard Classifications Repr. 1B
Giftige Stoffe Daten 87333-19-5(Hazardous Substances Data)
Toxizität LD50 (14 day) in male, female mice, male, female rats (mg/kg): 1194, 1158, 687, 608 i.v.; 10933, 10048, >10000, >10000 orally (Donaubauer, Mayer)

Ramipril Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R36/38:Reizt die Augen und die Haut.

S-Sätze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.

Beschreibung

Ramipril, a prodrug of ramiprilat, is a long-acting, tissue-specific and non-sulfhydryl ACE inhibitor useful in the treatment of mild to moderate hypertension. In animal studies ramipril exerted cardioprotective effects resembling those of bradykinin in cardiac reperfusion injuries. Ramipril is also reportedly useful in congestive heart failure.

Chemische Eigenschaften

White Solid

Verwenden

Angiotensin-converting enzyme (ACE) removes the C-terminal dipeptide from angiotensin I to form angiotensin II, a powerful vasoconstrictor. ACE is a key regulator of the renin-angiotensin system and an important drug target for the treatment of hypertension, congestive heart failure, and heart attacks, and also in preventing renal and retinal complications in diabetes. Ramipril is a second generation ACE inhibitor (IC50 = 4 nM) that acts as a prodrug, which is hydrolyzed in vivo to the active metabolite ramiprilat. The antihypertensive and cardioprotective efficacy of ramipril has been demonstrated in large-scale noncomparative studies and clinical trials.[Cayman Chemical]

Definition

ChEBI: A dipeptide that is the prodrug for ramiprilat, the active metabolite obtained by hydrolysis of the ethyl ester group. An angiotensin-converting enzyme (ACE) inhibitor, used to treat high blood pressure and congestive heart failure.

Allgemeine Beschreibung

Ramipril, (2S, 3aS, 6aS)-1-[(S)-N-[(S)-1-carboxy-3-phenylpropyl]alanyl]octahydrocyclopenta[b]-pyrrole-2-carboxylic acid 1-ethyl ester (Altace), ishydrolyzed to ramiprilat, its active diacid form, faster thanenalapril is hydrolyzed to its active diacid form. Peak serumconcentrations from a single oral dose are achieved between1.5 and 3 hours. The ramiprilate formed completely suppresses ACE activity for up to 12 hours, with 80% inhibitionof the enzyme still observed after 24 hours.

Ramipril Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Ethyl 3-benzoylacrylate Palladium carbon fine chemical catalyzer Benzyl ester Cyclohexan L-Alanin Cyclopenten Ethylacetat Dichlormethan Essigsure Methylpropionat Pyrrolidin Formamid 2-Azabicyclo[3.3.0]octane-3-carboxylic acid Benzenebutanoic acid, α-[[(1S)-2-chloro-1-methyl-2-oxoethyl]amino]-, ethyl ester, hydrochloride (αS)- 2-[N-[(S)-1-ETHOXYCARBONYL-3-PHENYLPROPYL]-L-ALANYL]-(1S,3S,5S)-2-AZABICYCLO[3.3.0]OCTANE-3-CARBOXYLIC ACID, BENZYL ESTER Ethyl (S)-2-[(S)-4-methyl-2,5-dioxo-1,3-oxazolidin-3-yl]-4-phenylbutyrate

Downstream Produkte

(2R,3aR,6aR)-Ramipril

Ramipril Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 491)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hangzhou ICH Biofarm Co., Ltd 		+86-0571-28186870; +undefined8613073685410
 sales@ichemie.com China 1002 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652
 info@fdachem.com China 20111 58
Hangzhou Hyper Chemicals Limited 		+86-0086-57187702781 +86-13675893055
 info@hyper-chem.com China 309 58
Shaanxi TNJONE Pharmaceutical Co., Ltd
sarah@tnjone.com China 1139 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512
 info@tianfuchem.com China 21533 55
career henan chemical co 		+86-0371-86658258
sales@coreychem.com China 29766 58
Xiamen AmoyChem Co., Ltd 		+86-86-5926051114
sales@amoychem.com China 6339 58
BOC Sciences 		+1-631-485-4226
inquiry@bocsci.com United States 19935 58
CONIER CHEM AND PHARMA LIMITED
sales@conier.com China 49906 58
TargetMol Chemicals Inc. 		+1-781-999-5354; +1-00000000000
 marketing@targetmol.com United States 32431 58

87333-19-5()Verwandte Suche:

Octan 2,2,4-Trimethylpentan Natriumoctan-1-sulfonatmonohydrat Nickeltetracarbonyl Carbonyl iron powder
  • 2-[[1-(2-ethoxycarbonyl-3,3a,4,5,6,6a-hexahydro-2H-cyclopenta[b]pyrrol-1-yl)-1-oxopropan-2-yl]amino]-4-phenylbutanoic acid
  • (2S,3aS,6aS)-1-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid
  • (2S,3aS,6aS)-1-[(2S)-2-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]aMino}propanoyl]-octahydrocyclopenta[b]pyrrole-2-carboxylic acid
  • RaMipril(Altace)
  • (2S,3aS,6aS)-
  • RaMipril API
  • Ranipril
  • (2s-(1(r*(r*)),2-alpha,3a-beta,6a-beta))-henylpropyl)amino)-1-oxopropyl
  • UNIPRIL
  • PRAMACE
  • RAMIPRIL
  • RAMACE
  • cyclopenta(b)pyrrole-2-carboxylicacid,octahydro-1-(2-((1-(ethoxycarbonyl)-3-p
  • [2S,3AS,6AS]-1-[(2S)-2-[[(1S)-1-(ETHOXYCARBONYL)-3-PHENYLPROPYL]AMINO]-1-OXOPROPYL]OCTAHYDROCYCLOPENTA[B]PYRROLE-2-CARBOXYLIC ACID
  • (2S,3AS,6AS)-1-[(S)-2-((S)-1-ETHOXYCARBONYL-3-PHENYL-PROPYLAMINO)-PROPIONYL]-OCTAHYDRO-CYCLOPENTA[B]PYRROLE-2-CARBOXYLIC ACID
  • (2s,3as,6as)-1((s)-n-((s)-1-carboxy-3-phenylpropyl)alanyl)octahydrocyclopenta(b)pyrrole-2-carboxylic acid 1-ethyl ester
  • RAMIPRIL, IMPURITY B(2S,3AS,6AS)-1-[(S)-2-[[(S)-1-[(METHYLETHOXY)CARBONYL]-3-PHENYLPROPYL]AMINO] PROPANOYL]OCTAHYDROCYCLOPENTA[B]PYRROLE-2-CARBOXYLIC ACID(RAMIPRIL ISOPROPYL ESTER) EP STANDARD
  • RAMIPRIL, USP STANDARD
  • RAMIPRIL, EP STANDARD
  • RAMIPRIL, RELATED COMPOUND A5-[[2-(AMINOETHYL)THIO]METHYL]-N,N-DIMETHYL-2-FURANMETHANINE HEMIFUMARATE SALT USP STANDARD
  • RAMIPRIL, IMPURITY DETHYL(2S)-2-[(3S,5AS,8AS,9AS)-3-METHYL-1,4-DIOXODECAHYDRO-1H-CYCLOPENTA[E]PYRROLO[1,2A]PYRAZIN-2-YL]-4-PHENYLBUTANOATE EP STANDARD
  • RAMIPRIL, IMPURITY C(2S,3AS,6AS)-1-[(S)-2-[[(S)-1-(ETHOXYCARBONYL)-3-CYCLOHEXYLPROPYL]AMINO]PROPANOYL]OCTAHYDROCYCLOPENTA[B]PYRROLE-2-CARBOXYLIC ACID (HEXAHYDRORAMIPRIL) EP STANDARD
  • RAMIPRIL, IMPURITY A(2S,3AS,6AS)-1-[(S)-2-[[(S)-1-(METHOXYCARBONYL)-3-PHENYLPROPYL]AMINO]PROPANOLY]OCTAHYDROCYCLOPENTA[B]PYRROLE-2-CARBOXYLIC ACID (RAMIPRIL METHYLESTER) EP STANDARD
  • ALTACE
  • CARDACE
  • HOE-498
  • DELIX
  • Raimipril
  • RamiprilC23H32N205
  • HOE-498, Altace, Cardace, Delix, Pramace, Ramace, Unipril
  • Cyclopentabpyrrole-2-carboxylic acid, 1-(2S)-2-(1S)-1-(ethoxycarbonyl)-3-phenylpropylamino-1-oxopropyloctahydro-, (2S,3aS,6aS)-
  • (2s,3as,6as)-1-[(s)-2-[[(s)-1-(ethoxycarbonyl)-3phenylpropyl]amino]propanoyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid
  • cyclopenta(b)pyrrole-2-carboxylic acid, octahydro-1-(2-((1-(ethoxycarbonyl)-3-phoeramipril
  • (2S,3aS,6aS)-1-((S)-2-((S)-1-ethoxy-1-oxo-4-
  • Ramioril
  • (2S,3AS,6AS)-1-((S)-2-((S)-1-ETHOXY-1-OXO-4-PHENYLBUTAN-2-YLAMINO)PROPANOYL)-OCTAHYDROCYCLOPENTA[B]PYRROLE-2-CARBOXYLIC ACID
  • Trimce
  • vesdil
  • (1S,5S,7S)-8-[(2S)-2-[[(1S)-1-Ethoxycarbonyl-3-phenyl-propyl]amino]propanoyl]-8-azabicyclo[3.3.0]octane-7-carboxylic acid
  • Cyclopenta(b)pyrrole-2-carboxylic acid, octahydro-1-(2-((1-(ethoxycarbonyl)-3-phenylpropyl) amino)-1-oxopropyl), (2S-(1(R*(R*)),2-alpha,3a-beta,6a-beta))
  • 4-[2-(1-Ethoxycarbonyl-3-phenyl-propyl)aminopropanoyl]-4-azabicyclo[3.3.0]octane-3-carboxylic acid
  • (2S,3aβ,6aβ)-1-[(S)-2-[[(S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahydrocyclopenta[b]pyrrole-2α-carboxylic acid
  • Ramipril (125 mg)
  • CAS 87333-19-5 Ramipril Powder
  • 2S,3aS,6aS)-1((S)-N-((S)-1-Carboxy-3-phenylpropyl)alanyl)octahydrocyclopenta(b)pyrrole-2-carboxylic acid 1-ethyl ester
  • Tritace, [2S,3aS,6aS]-1-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid
  • [2S-[1[R^<*>^ (R^<*>^)]，2α，3αβ，6αβ]]-1-[2-[[1- (Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahy-drocyclopenta[b]pyrrole-2-carboxylic acid
  • Ramipril CRS
  • Calcipotriol impurity MC-1080
  • Carasel
  • Ramipril USP/EP/BP
  • Ramipril (1.0 mg/mL in Methanol)
  • Ramipril (HOE-498)
  • RamiprilQ: What is Ramipril Q: What is the CAS Number of Ramipril Q: What is the storage condition of Ramipril Q: What are the applications of Ramipril
  • Ramipril (1598303)
  • ethyl (1Z)-N-[[2-[4-[[(4-fluorophenyl)methyl]carbamoyl]-5-hydroxy-1-methyl-6-oxo-1,6-dihydropyrimidin-2-yl]propan-2-yl]oxamoyl]ethanehydrazonate
  • Ramipril Sec Std as per BP
  • Remipril
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