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Roscovitine

Roscovitine Struktur
186692-46-6
CAS-Nr.
186692-46-6
Englisch Name:
Roscovitine
Synonyma:
Seliciclib;Roscovitin;Roscovitine (Seliciclib,CYC202);CYC 202;Posiphe;CS-1845;P34 CDC2;ROSCOVITINE;Roscoviline;(R)-2-(1-ETHY
CBNumber:
CB0367185
Summenformel:
C19H26N6O
Molgewicht:
354.45
MOL-Datei:
186692-46-6.mol
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Roscovitine Eigenschaften

Schmelzpunkt:
106~107℃
Siedepunkt:
577.5±60.0 °C(Predicted)
Dichte
1.3
storage temp. 
-20°C
Löslichkeit
Soluble in DMSO (up to 10 mg/ml, with warming) or in Ethanol (up to 10 mg/ml).
pka
14.56±0.10(Predicted)
Aggregatzustand
White to off-white solid
Farbe
White
Biologische Quelle
synthetic (organic)
Stabilität:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
InChI
InChI=1S/C19H26N6O/c1-4-15(11-26)22-19-23-17(20-10-14-8-6-5-7-9-14)16-18(24-19)25(12-21-16)13(2)3/h5-9,12-13,15,26H,4,10-11H2,1-3H3,(H2,20,22,23,24)/t15-/m1/s1
InChIKey
BTIHMVBBUGXLCJ-OAHLLOKOSA-N
SMILES
C(O)[C@H](NC1=NC(NCC2=CC=CC=C2)=C2C(=N1)N(C(C)C)C=N2)CC
CAS Datenbank
186692-46-6(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
S-Sätze: 22-24/25
WGK Germany  3
HS Code  29335990
Speicherklasse 11 - Combustible Solids
Bildanzeige (GHS) Exclamation Mark (GHS07)
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung P264, P280, P305+P351+P338,P337+P313P
Sicherheit
P261 Einatmen von Staub vermeiden.
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P271 Nur im Freien oder in gut belüfteten Räumen verwenden.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.
P332+P313 Bei Hautreizung: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen.
P337+P313 Bei anhaltender Augenreizung: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen.
P501 Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

Roscovitine Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:

S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.

Definition

ChEBI: 2,6-Diaminopurine carrying benzylamino, (2R)-1-hydroxybutan-2-yl and isopropyl substituents at C-6, C-2-N and N-9 respectively. It is an experimental drug candidate in the family of pharmacological cyclin-dependent kinase (CDK) inhibitors.

Allgemeine Beschreibung

A potent, reversible, and selective inhibitor of cyclin-dependent kinases (Cdks) that exhibits about ten-fold greater efficacy towards p34cdk1 and p33cdk2 and twenty-fold greater efficacy towards p33cdk5 relative to Olomoucine (Cat. No. 495620). Inhibits p34cdk1/cyclin B (IC50 = 650 nM), p33cdk2/cyclin A (IC50 = 700 nM), p33cdk2/cyclin E (IC50 = 700 nM), and p33cdk5/p35 (IC50 = 200 nM) by competing for the ATP binding domain of the kinases. Exhibits reduced sensitivity towards related kinases including ERK1 and ERK2 (IC50 = 34 μM and 14 μM, respectively). Roscovitine does not significantly affect the activity of other protein kinases even at 100 μM, including p34cdk4/cyclin D1 and p40cdk6/cyclin D2. Compared to olomoucine, roscovitine displays increased anti-mitotic activity at the G1/S and G2/M phases of the cell cycle. A 50 mM (5 mg/282 μl) solution of Roscovitine (Cat. No. 557364) in DMSO is also available.

Anticancer Research

Roscovitine a derivative of olomoucine which is isolated from Raphanus sativus isunder clinical trials (Shoeb 2006).

Roscovitine Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Roscovitine Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 270)Lieferanten
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GIHI CHEMICALS CO.,LIMITED 		+86-571-86217390; +8618058761490
 info@gihichemicals.com China 49859 58
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 sales@anbuchem.com China 5812 58
  • 2-(R)-[[9-(1-Methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol, 6-(Benzylamino)-2(R)-[[1-(hydroxymethyl)propyl]amino]-9-isopropylpurine
  • (2R)-2-[[6-(benzylamino)-9-propan-2-yl-purin-2-yl]amino]butan-1-ol
  • 2-(R)-(1-ETHYL-2-HYDROXYETHYLAMINO)-6-BENZYLAMINO-9-ISOPROPYLPURINE
  • 2-(1-ETHYL-2-HYDROXYETHYLAMINO)-6-BENZYLAMINO-9-ISOPROPYLPURINE
  • 6-BENZYLAMINO-2-(R)-[(1-ETHYL)-2-HYDROXYETHYLAMINO]-9-ISOPROPYLPURINE
  • ROSCOVITINE
  • (R)-ROSCOVITINE
  • (R)-2-(1-ETHYL-2-HYDROXYETHYLAMINO)-6-BENZYLAMINO-9-ISOPROPYLPURINE
  • P34 CDC2
  • R-ROSCOVITINE 98% (HPLC)
  • ROSCOVITINE 95+%
  • 1-Butanol, 2-[[9-(1-methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-, (2R)-
  • 2-(r)-[[9-(1-methylethyl)-6-[(phenylmethyl)amino]-9h-purin-2-yl]amino]-1-butanol
  • Roscovitin
  • 6-(Benzylamino)-2(R)-[[1-(hydroxymethyl)propyl]amino]-9-isopropylpurine
  • Roscovitine (CYC202,Seliciclib)
  • 6-Benzylamino-2[(R)-(1'-ethyl-2'-hydroxyethylamino)]-9-isopropylpurine Roscovitine
  • Roscovitine,2-(R)-[[9-(1-Methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol, 6-(Benzylamino)-2(R)-[[1-(hydroxymethyl)propyl]amino]-9-isopropylpurine
  • Roscovitine(CYC202)
  • 2-[[9-(1-Methylethyl)-6-[(phenylMethyl)aMino]-9H-purin-2-yl]aMino]-
  • (R)-2-(1-ETHY
  • Roscovitine (Seliciclib)
  • (2R)-2-[[9-(1-Methylethyl)-6-[(phenylMethyl)aMino]-9H-purin-2-yl]aMino]-1-butanol
  • (R)-2-[[9-(1-Methylethyl)-6-[(phenylMethyl)aMino]-9H-purin-2-yl]aMino]-1-butanol
  • CYC 202
  • Roscovitine (Seliciclib,CYC202)
  • Roscoviline
  • Posiphe
  • CYC-202(ROSCOVITINE)
  • 6-(Benzylamino)-2(R)-[[1-(hydroxymethyl)propyl]amino]-9-isopropylpurine Roscovitine
  • 6-(Benzylamino)-2(R)-[[1-(hydroxymethyl)propyl]amino]-9-isopropylpurine Roscovitine (Seliciclib,CYC202)
  • Roscovitine (R)-Roscovitine
  • Roscovitine, >=98%
  • Roscovitine - CAS 186692-46-6 - Calbiochem
  • CS-1845
  • SELICICLIB (ROSCOVITINE)
  • CYC202;R-ROSCOVITINE;SELICICLIB
  • 2-(6-Benzylamino-9-isopropyl-9H-purin-2-ylamino)-butan-1-ol （CYC202)
  • ROSCOVITINE USP/EP/BP
  • Seliciclib-d7
  • Roscovitine, CDK inhibitor
  • Seliciclib, 10 mM in DMSO
  • Roscovitine >=98% (TLC)
  • (R)-2-((6-(benzylamino)-9-isopropyl-9H-purine-2-yl)amino)butyl-1-ol
  • (R)-2-[[6-(Benzylamino)-9-isopropyl-9H-purin-2-yl]amino]-1-butanol
  • Seliciclib
  • 186692-46-6
  • Cell Signaling and Neuroscience
  • Cell Cycle
  • Cell Cycle Regulators
  • Cell Biology
  • BioChemical
  • Apoptosis and Cell Cycle
  • Inhibitors
  • Apis
  • API intermediates
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