Chinese english Germany Japanese Korea

Entecavir

Entecavir Struktur
142217-69-4
CAS-Nr.
142217-69-4
Englisch Name:
Entecavir
Synonyma:
Baraclude;Etv;entikawei;2-amino-9-((1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl)-1H-purin-6(9H)-one;CS-863;CS-1236;Entecavi;SQ 34676;Enticavir;ENTECAVIR
CBNumber:
CB0506719
Summenformel:
C12H15N5O3
Molgewicht:
277.28
MOL-Datei:
142217-69-4.mol
Request For Quotation

Entecavir Eigenschaften

Schmelzpunkt:
249-252°C
Siedepunkt:
661.4±65.0 °C(Predicted)
Dichte
1.81±0.1 g/cm3(Predicted)
storage temp. 
-20°C
Löslichkeit
DMSO (Slightly), Methanol (Sparingly)
pka
14.22±0.60(Predicted)
Aggregatzustand
powder
Farbe
white to beige
Optische Rotation
[α]/D +25 to +40°, c = 0.2 in H2O
Wasserlöslichkeit
H2O: 0.5mg/mL, clear (warmed)
Henry's Law Constant
6.2×1015 mol/(m3Pa) at 25℃, HSDB (2015)
Stabilität:
Hygroscopic
InChI
InChI=1S/C12H15N5O3/c1-5-6(3-18)8(19)2-7(5)17-4-14-9-10(17)15-12(13)16-11(9)20/h4,6-8,18-19H,1-3H2,(H3,13,15,16,20)/t6-,7-,8-/m0/s1
InChIKey
QDGZDCVAUDNJFG-FXQIFTODSA-N
SMILES
N1C2=C(N=C(N)NC2=O)N([C@H]2C[C@H](O)[C@@H](CO)C2=C)C=1
CAS Datenbank
142217-69-4(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
S-Sätze: 24/25
WGK Germany  3
HS Code  29339900
Speicherklasse 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral
Carc. 2
Giftige Stoffe Daten 142217-69-4(Hazardous Substances Data)
Bildanzeige (GHS) Exclamation Mark (GHS07)
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitsschädlich bei Verschlucken. Akute Toxizität oral Kategorie 4 Warnung P264, P270, P301+P312, P330, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung P264, P280, P302+P352, P321,P332+P313, P362
H320 Causes eye irritation Serious eye damage/eye irritation Category 2B Warnung P264, P305+P351+P338,P337+P313
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizität (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P301+P312 BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P330 Mund ausspülen.

Entecavir Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Entecavir is a cyclopentyl guanosine analog launched for the once-daily oral treatment of chronic hepatitis B virus (HBV) infection, and it is the third nucleoside or nucleotide analog to be marketed for this indication. Lamivudine, a deoxythiacytosine analog, and adefovir dipivoxil, a nucleotide analog, have been marketed since 1998 and 2002, respectively. Entecavir and adefovir are specifically indicated for HBV, whereas lamivudine is indicated for both HBV and HIV infections.

Chemische Eigenschaften

White to Off-White/Yellow Crystalline Powder

Definition

ChEBI: Guanine substituted at the 9 position by a 4-hydroxy-3-(hydroxymethyl)-2-methylidenecyclopentyl group. A synthetic analogue of 2'-deoxyguanosine, it is a nucleoside reverse transcriptase inhibitor with selective antiviral activity against hepatitis B virus Entecavir is phosphorylated intracellularly to the active triphosphate form, which competes with deoxyguanosine triphosphate, the natural substrate of hepatitis B virus reverse transcriptase, inhibiting every stage of the enzyme's activity, although it ha no activity against HIV. It is used for the treatment of chronic hepatitis B.

Handelsname

Baraclude (BMS)

Clinical Use

Treatment of chronic hepatitis B virus infection in patients >16 years of age.
Entecavir comes as a tablet and solution (liquid) to take by mouth. It is usually taken once a day on an empty stomach, at least 2 hours after a meal and at least 2 hours before the next meal. Take entecavir at around the same time every day.

Research

In a retrospective cohort study that includes 182 patients with chronic hepatitis B[1], Entecavir (ETV) demonstrated significant advantages in terms of both efficacy and cost-effectiveness compared to tenofovir amibufenamide (TMF), with better clinical outcomes and higher economic value. These results suggest that ETV may be considered a potentially preferred antiviral regimen for patients with CHB.

Entecavir Upstream-Materialien And Downstream Produkte

Upstream-Materialien

6H-Purin-6-one, 9-[(1S,3R,4S)-4-(acetyloxy)-2-methylene-3-[[(4-nitrobenzoyl)oxy]methyl]cyclopentyl]-2-amino-1,9-dihydro- Cyclopentanemethanol, 5-(acetyloxy)-3-(2-amino-6-chloro-9H-purin-9-yl)-2-methylene-, 1-acetate, (1R,3S,5S)-

Downstream Produkte

Entecavir Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 582)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Baoji Guokang Healthchem Co., Ltd.
+86-0917-3909592 +86-13892490616
 gksales1@gk-bio.com China 9036 58
Shaanxi TNJONE Pharmaceutical Co., Ltd
sarah@tnjone.com China 1139 58
Hefei Lbao Physical & Chemical Science Co.,Ltd 		+1-5184799099;
lbaochemicals@gmail.com China 670 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806
 sales@capot.com China 29626 60
career henan chemical co 		+86-0371-86658258
sales@coreychem.com China 29766 58
Xiamen AmoyChem Co., Ltd 		+86-86-5926051114
sales@amoychem.com China 6339 58
BOC Sciences 		+1-631-485-4226
inquiry@bocsci.com United States 19935 58
CONIER CHEM AND PHARMA LIMITED
sales@conier.com China 49906 58
Shaanxi Dideu Medichem Co. Ltd 		+86-29-87569262 +86-15003564040
 1056@dideu.com China 3970 58
Linyi Changqing Chemical Co., LTD 		+86-0532-55729510 +86-15853232676
 marketing@echemi.com China 287 58

142217-69-4()Verwandte Suche:

ALTRENOGEST Glycin Trometamol Natrium-N-(hydroxymethyl)glycinat Ethylidintrimethanol Aminocapronsure 2-Hydroxyethylmethacrylat Guanin methylol cellulose 3,6-Bis[(4-chlor-2-phosphonophenyl)azo]-4,5-dihydroxynaphthalin-2,7-disulfonsure CARBOXYMETHYLCELLULOSE SODIUM SALT Propylidintrimethanol 2-(Hydroxymethyl)-2-nitro-1,3-propandiol TRIS EDTA ACETATE BUFFER, 10X, DNASE, RNASE AND PROTEASE FREE, PH 8.3, FOR MOLECULAR BIOLOGY AMINO ACIDS
  • Entecavir USP Impurity B
  • Aids098045
  • Aids-098045
  • Etv
  • Enticavir
  • EntikaweiPian
  • 2-Amino-9-((1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl)-3H-purin-6(9H)-one ,99.7%
  • (1S,3R,4S)-9-[4-Hydroxy-3-(hydroxyMethyl)-2-Methylenecyclopentyl]guanine
  • Entecavir Anhydrous
  • 20MG/100MG/100G
  • Entecavir Tablets
  • 2-amino-9-((1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl)-1H-purin-6(9H)-one
  • 2-amino-9-[(1R,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-3H-purin-6-one hydrate
  • entikawei
  • CS-863
  • CS-1236
  • Entecavir, BMS200475
  • Entecavir (as hydrate)
  • Entecavir,99%e.e.
  • Entecavi
  • ENTECAVIR, 98-102%
  • entecavir Baraclude
  • 2-Amino-9-[4-hydroxy-3-(hydroxymethyl)-2-methylidene-cyclopentyl]-3H-purin-6-one, Baraclude
  • ENTECAVIR
  • 2-Amino-1,9-dihydro-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one
  • 2-Amino-9-[4-hydroxy-3-(hydroxymethyl)-2-methylidene-cyclopentyl]-3H-purin-6-one
  • SQ 34676
  • 6-H-Purin-6-one-,2-amino-1,9-dihydro-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]
  • Entecavir（SQ 34676
  • Entecavir/Entecavir Monohydrate
  • Entecavir USP/EP/BP
  • 2-Amino-9-(4-hydroxy-3-hydroxymethyl-2-methylene-cyclopentyl)-3,9-dihydro-purin-6-one
  • 2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylidenecyclopentyl]-1,9-dihydro-6H-purin-6-one
  • 2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylene-cyclopentyl]-1H-purin-6-one
  • Entecavir, 10 mM in DMSO
  • 2-amino-9-((1s,3r,4s)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl)-1,9-dihydro-6h-purin-6-one
  • 2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylidenecyclopentyl]-6,9-dihydro-1H-purin-6-one
  • Baraclude
  • 142217-69-4
  • 209216-23-6
  • 12477-69-4
  • The latest anti hepatitis b anti-aids drugs
  • Anti-virals
  • Heterocycles
  • API
  • Nucleotides and Nucleosides
  • Bases & Related Reagents
  • Intermediates & Fine Chemicals
  • Nucleotides
  • Pharmaceuticals
  • Inhibitors
  • Antiviral Agents
  • 142217-69-4
Copyright 2019 © ChemicalBook. All rights reserved