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Droxicam

Droxicam Struktur
90101-16-9
CAS-Nr.
90101-16-9
Englisch Name:
Droxicam
Synonyma:
E-318;E-3128;Droxar;Ombolan;Dobenam;DROXICAM;Droxicamum;Droxicam USP/EP/BP;5-methyl-6,6-dioxo-3-pyridin-2-yl-[1,3]oxazino[5,6-c][1,2]benzothiazine-2,4-dione;5-Methyl-3-(2-pyridyl)-2H,5H-1,3-oxazino[5,6-c][1,2]benzothiazine-2,4(3H)-dione 6,6-dioxide
CBNumber:
CB0664772
Summenformel:
C16H11N3O5S
Molgewicht:
357.34
MOL-Datei:
90101-16-9.mol
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Droxicam Eigenschaften

Schmelzpunkt:
259-261°
Siedepunkt:
554.7±60.0 °C(Predicted)
Dichte
1.68±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
Löslichkeit
DMSO (Slightly), Methanol (Slightly, Heated)
pka
3.80±0.19(Predicted)
Aggregatzustand
Solid
Farbe
Off-White to Pale Yellow
CAS Datenbank
90101-16-9
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Toxizität LD50 orally in male, female mice, and male, female rats: 6192, 8841, 1434, 1994 mg/kg (Soler, 1986)
Bildanzeige (GHS) Exclamation Mark (GHS07)
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitsschädlich bei Verschlucken. Akute Toxizität oral Kategorie 4 Warnung P264, P270, P301+P312, P330, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung P264, P280, P305+P351+P338,P337+P313P
H332 Gesundheitsschädlich bei Einatmen. Akute Toxizität inhalativ Kategorie 4 Warnung P261, P271, P304+P340, P312
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizität (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung
Sicherheit
P261 Einatmen von Staub vermeiden.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

Droxicam Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Droxicam is an orally-active prodrug of piroxicam useful in the treatment of spinal osteoarthritis. Although it has a pharmacological profile comparable to piroxicam, droxicam's experimental ulcerogenic effect is ten times less. In animal studies droxicam is also reported to have analgesic and antipyretic activities, with no cardiovascular or respiratory effects.

Verwenden

Droxicam is a non-steroidal anti-inflammatory drug.

Definition

ChEBI: An organic heterotricyclic compound that is 2H,5H-[1,3]oxazino[5,6-c][1,2]benzothiazine-2,4(3H)-dione 6,6-dioxide substituted at positions 3 and 5 by pyridin-2-yl and methyl groups respe tively. A prodrug of piroxicam, it is used for the relief of pain and inflammation in musculoskeletal disorders such as rheumatoid arthritis and osteoarthritis.

Weltgesundheitsorganisation (WHO)

Droxicam is authorized to be marketed in many European countries. Although droxicam is metabolized to piroxicam, it is considered that the risk of hepatic damage differs from that shown by other NSAIDs products, including piroxicam.

Droxicam Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Polyethylene glycol dimethyl ether Phenylcarbamat

Downstream Produkte

Droxicam Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 48)Lieferanten
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90101-16-9()Verwandte Suche:

Lornoxicam Sulfamethoxazol Piroxicam Basic Violet 1 Methylacrylat Meloxicam Methyl-4-hydroxybenzoat Famoxadone Methylacetat Kresoxim-methyl Fenoxaprop-P Paraquat-dichlorid Methanol Isoxazol Pralmorelin Acetonitril Methyl Chrysen
  • DROXICAM
  • 5-Methyl-3-(2-pyridyl)-2H,5H-1,3-oxazino[5,6-c][1,2]benzothiazine-2,4(3H)-dione 6,6-dioxide
  • 5-Methyl-3-(pyridin-2-yl)-2H,5H-1,3-oxazino[5,6-c][1,2]benzothiazine-2,4(3H)-dione 6,6-dioxide
  • E-318
  • 5-Methyl-3-(2-pyridinyl)-2H，5 H-1，3-oxaZino[5，6-c][1，2]benzothiazine-2，4(3H)-dione-6，6-dioxide
  • Dobenam
  • Droxar
  • E-3128
  • Ombolan
  • 5-Methyl-3-(pyridin-2-yl)benzo[5,6][1,2]thiazino[3,4-e][1,3]oxazine-2,4(3H,5H)-dione 6,6-dioxide
  • 5-Methyl-3-(pyridin-2-yl)benzo[5,6][1,2]thiazino-[3,4-e][1,3]oxazine-2,4(3H,5H)-dione 6,6-diox
  • 5-methyl-6,6-dioxo-3-pyridin-2-yl-[1,3]oxazino[5,6-c][1,2]benzothiazine-2,4-dione
  • 2H,5H-1,3-Oxazino[5,6-c][1,2]benzothiazine-2,4(3H)-dione, 5-methyl-3-(2-pyridinyl)-, 6,6-dioxide
  • Droxicam USP/EP/BP
  • Droxicamum
  • 5-Methyl-3-(pyridin-2-yl)-3-hydro-2H,5H-benzo[5,6][1,2]thiazino[3,4-e][1,3]oxazine-2,4-dione 6,6-dioxide
  • 90101-16-9
  • C16H11N3O5S
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