(1R, 2S 3R, 6S)-1,2-Dimethyl-3,6-epoxycyclohexan-1,2-dicarbon-säureanhydrid Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R28:Sehr giftig beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R38:Reizt die Haut.
R37:Reizt die Atmungsorgane.
R36:Reizt die Augen.
R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
S-Sätze Betriebsanweisung:
S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Chemische Eigenschaften
Cantharidin is a brown to black powder.
Verwenden
Cantharidin is a natural toxin produced by blister beetles that moderately inhibits protein phosphatases 1 (PP1) (IC50 = 1.7 μM) and PP2A (IC50 = 0.2 μM) and only weakly inhibits the activity of PP2B (IC50 = 1 mM). It has been shown to stimulate cell cycle progression and induce premature mitosis, used topically (0.7%) as an anti-wart treatment, and has been shown to be active in cervical, tongue, neuroblastoma, bone, leukemia, ovarian, colon, and various other cancer cell lines.
Definition
ChEBI: A monoterpenoid with an epoxy-bridged cyclic dicarboxylic anhydride structure secreted by many species of blister beetle, and most notably by the Spanish fly, Lytta vesicatoria. Natural toxin inhibitor of protein phosphatases 1 and 2A.
Indications
Cantharidin, from the beetle Cantharis vesicatoria, causes intraepidermal vesiculation
and is used in the treatment of warts and other benign cutaneous lesions.
Cantharidin is extremely toxic if taken internally; it should not be prescribed for
at-home use.
Cantharidin (Cantharone), a mitochondrial poison derived from the blister beetle Cantharis vesicatoria, leads to changes in cell membranes, epidermal cell dyshesion, acantholysis, and blister formation and is also useful. Cantharidin can be compounded with salicylic acid and podophyllin resin; occlusion for only 2 hours is needed with this combination. Thick hyperkeratotic lesions should be pared down before painting. The lesion should then be painted with cantharidin, allowed to dry, and covered with Blenderm or other nonporous occlusive tape; 40% salicylic acid plaster may be used to achieve greater activity. The tape is left on for 24 hours or until the area begins to hurt. A blister, often hemorrhagic, will form, break, crust, and fall off in 7 to 14 days; at this time, the lesion is pared down, and any wart remnants are retreated. Because the effect of cantharidin is entirely intraepidermal, no scarring ensues. Ring-like or "donut configuration" recurrences may be seen occasionally after treatment with cantharidin or, at times, following liquid nitrogen therapy. Owing to this agent’s toxicity, application by a physician is recommended. Verrusol, which contains 30% salicylic acid, 5% podophyllin, and 1% cantharidin, may be used in the same manner.
Allgemeine Beschreibung
Brown to black powder or plates or scales. Formerly used as a counterirritant and vesicant. Used for the removal of warts. Used as an experimental anti tumor agent. Active ingredient in spanish fly, a reputed aphrodisiac.
Reaktivität anzeigen
Organic anhydrides, such as Cantharidin, are incompatible with acids, strong oxidizing agents, alcohols, amines, and bases.
Hazard
Extremely toxic; questionable carcinogen;
powerful irritant to all cells and tissues; deadly poi-
son; respiratory failure; death.
Health Hazard
Cantharidin is classified as super toxic. Probable oral lethal dose in humans is less than 5 mg/kg or a taste of less than 7 drops for a 70 kg (150 lb.) person. It is very toxic by absorption through skin.
Brandgefahr
When heated to decomposition Cantharidin emits acrid smoke and irritating fumes.
Biologische Aktivität
Natural toxin inhibitor of protein phosphatases 1 and 2A (K i values are 1.1 and 0.19 μ M respectively); similar to okadaic acid (9,10-Deepithio-9,10-didehydroacanthifolicin ). Displays > 500-fold selectivity over PP2B.
mögliche Exposition
Formerly used as a counterirritant and
vesicant. Also used for the removal of benign epithelial
growths, e.g., warts. Used as an experimental antitumor
agent. The active ingredient in “Spanish fly,” a reputed
aphrodisia
Versand/Shipping
Cantharidin is not specifically listed in the DOT
Performance-Oriented Packaging Standards with respect
to labeling requirements or restrictions on shipping
quantities.
Waste disposal
It is inappropriate and possibly dangerous to the environment to dispose of expired or
waste drugs and pharmaceuticals by flushing them down
the toilet or discarding them to the trash. Household quantities of expired or waste pharmaceuticals may be mixed
with wet cat litter or coffee grounds, double-bagged in
plastic, discard in trash. Larger quantities shall carefully
take into consideration applicable DEA, EPA, and FDA
regulations. If possible return the pharmaceutical to the
manufacturer for proper disposal being careful to properly
label and securely package the material. Alternatively, the
waste pharmaceutical shall be labeled, securely packaged,
and transported by a state licensed medical waste contractor
to dispose by burial in a licensed hazardous or toxic waste
landfill or incinerator.
(1R, 2S 3R, 6S)-1,2-Dimethyl-3,6-epoxycyclohexan-1,2-dicarbon-säureanhydrid Upstream-Materialien And Downstream Produkte
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3,4-Thiophenedicarboxylic acid, 2,5-dihydro-, dimethyl ester
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Thieno[3,4-c]furan-1,3(4H,6H)-dione
3-Thiophenecarboxylic acid, 4-cyanotetrahydro-4-hydroxy-, methyl ester
Methyltetrahydro-4-oxo-3-thenoat
Methyl-3-[(2-methoxy-2-oxoethyl)thio]propionat
Furan
Downstream Produkte
