Bendamustine hydrochloride
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- CAS-Nr.
- 3543-75-7
- Englisch Name:
- Bendamustine hydrochloride
- Synonyma:
- BENDAMUSTINE HCL;BendaMustine hydrochloride hydrate;EP3101;Treanda;SDX 105;DD6304600;CYTOSTASAN;Ribomustin;ZIMET-33/93;Cytostasane
- CBNumber:
- CB0777896
- Summenformel:
- C16H22Cl3N3O2
- Molgewicht:
- 394.72
- MOL-Datei:
- 3543-75-7.mol
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Bendamustine hydrochloride Eigenschaften
- Schmelzpunkt:
- 149-151°C
- storage temp.
- room temp
- Löslichkeit
- H2O: >30mg/mL
- Aggregatzustand
- powder
- Farbe
- off-white
- Merck
- 14,1034
- Major Application
- (Pharmaceutical small molecule)
- InChI
- InChI=1S/C16H21Cl2N3O2.ClH/c1-20-14-6-5-12(21(9-7-17)10-8-18)11-13(14)19-15(20)3-2-4-16(22)23;/h5-6,11H,2-4,7-10H2,1H3,(H,22,23);1H
- InChIKey
- ZHSKUOZOLHMKEA-UHFFFAOYSA-N
- SMILES
- C12N=C(CCCC(=O)O)N(C)C=1C=CC(N(CCCl)CCCl)=C2.Cl
- CAS Datenbank
- 3543-75-7(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Kennzeichnung gefährlicher |
T,Xn |
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| R-Sätze: |
60-61-22-40 |
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| S-Sätze: |
36-37 |
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| RIDADR |
UN 2811 6.1 / PGIII |
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| WGK Germany |
3 |
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| RTECS-Nr. |
DE1590000 |
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| HazardClass |
6.1 |
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| PackingGroup |
III |
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| HS Code |
29339900 |
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| Speicherklasse |
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects |
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| Hazard Classifications |
Acute Tox. 3 Oral
Carc. 2
Muta. 2
Repr. 2 |
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| Toxizität |
LD50 (monohydrate) in mice, rats (mg/kg): 400-500, 200-300 orally; 80, 40 i.v. (Horn) |
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| Bildanzeige (GHS) |
 
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| Alarmwort |
Achtung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H301 |
Giftig bei Verschlucken. |
Akute Toxizität oral |
Kategorie 3 |
Achtung |
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P264, P270, P301+P310, P321, P330,P405, P501 |
| H341 |
Kann vermutlich genetische Defekte verursachen. |
Keimzellmutagenität |
Kategorie 2 |
Warnung |
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P201,P202, P281, P308+P313, P405,P501 |
| H351 |
Kann vermutlich Krebs verursachen. |
Karzinogenität |
Kategorie 2 |
Warnung |
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P201, P202, P281, P308+P313, P405,P501 |
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| Sicherheit |
| P201 |
Vor Gebrauch besondere Anweisungen einholen. |
| P202 |
Vor Gebrauch alle Sicherheitshinweise lesen und verstehen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P301+P310 |
BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
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Bendamustine hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden
Chemische Eigenschaften
Pale Brown Crystals
Verwenden
Bendamustine hydrochloride hydrate has been used as:
- a chemotherapy agent for chronic lymphocytic leukemia (CLL) samples to monitor spliced and unspliced gene expression
- an inhibitor to E3 ubiquitin-protein ligase RNF3 (HOIP) inmatrix-assisted laser desorption ionization time-of-flight mass spectrometry(MALDI-TOF) assay
- a cytotoxic chemotherapeutic drug in high-throughput screening to test interaction with BAY87-2243
Allgemeine Beschreibung
Bendamustine comprises 2-chloroethylamine alkylating group, a butyric acid side chain and a benzimidazole ring in its structure and is a nitrogen mustard. It is catabolized in the liver by the enzyme cytochrome P450 1A2 into γ hydroxyl-bendamustine and
N-desmethyl-bendamustine.
Biologische Aktivität
Cytostatic agent that displays activity in non-Hodgkin's lymphomas. Exhibits bifunctionality; combines DNA alkylating properties with those of purine analogs.
Bendamustine hydrochloride Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Pentanoic acid, 5-[(2,4-dinitrophenyl)methylamino]-5-oxo-, methyl ester
Pentanoic acid, 5-[(2,4-dinitrophenyl)amino]-5-oxo-, methyl ester
isopropyl 4-(1-methyl-5-nitro-1H-benzo[d]imidazol-2-yl)butanoate
5-[Bis(2-chloroethyl)aMino]-1-Methyl-1H-benziMidazole-2-butanoic Acid Methyl Ester
1H-Benzimidazole-2-butanoic acid, 5-[bis(2-hydroxyethyl)amino]-1-methyl-, 1-methylethyl ester
1-Chlor-2,4-dinitrobenzol
5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester
Methyl-4-chlorformylbutyrat
BendaMustine IMpurity C
2,4-Dinitroanilin
5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid methyl ester
N-Methyl-2,4-dinitroanilin
N1-Methyl-4-nitro-o-phenyldiamin
Downstream Produkte
Bendamustine hydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 449)Lieferanten
3543-75-7()Verwandte Suche:
- 1-methyl-5-bis(2-chloroethyl)amino-2-benzimidazolinebutryricacihydrochlor
- gamma(1-methyl-5-bis(beta-chloraethyl)aminobenzimidazoyl-2)buttersaeurehydro
- CytostasanHCl
- bendamustine hydrochloride
- BENDAMUSTIN HYDROCHLORIDE
- CYTOSTASAN
- 1-methyl-5-bis(2-chloroethyl)amino-2-benzimidazolinebutryric acid hydrochloride
- 4-[5-[bis(2-chloroethyl)amino]-1-methylbenzimidazol-2-yl]butanoic acid hydrochloride
- Bendamustina
- DD6304600
- SDX-105 Ribomustin.
- TREANDA;BENDAMUSTINUM;BENDAMUSTINA;DD6304600;SDX-105 RIBOMUSTIN.
- 4-(5-(bis(2-chloroethyl)amino)
- Bendamustine HCL (SDX-105, Cytostasane)
- 1H-Benzimidazole-2-butanoicacid,5-[bis(2-chloroethyl)amino]-1-methyl-,hydrochloride
- ZIMET-33/93
- 4-(5-(Bis(2-chloroethyl)aMino)-1-Methyl-2,3-dihydro-1H-benzo[d]iMidazol-2-yl)butanoic acid hydrochloride
- 4-(6-(bis(2-chloroethyl)aMino)-1-Methyl-1H-benzo[d]iMidazol-2-yl)butanoic acid
- BendaMustine Hydrochloride (SDX-105)
- 5-[Bis(2-chloroethyl)-amino]-1-methyl-1H-benzimidazole-2-butanoic Acid Hydrochloride
- Ribomustin
- Treanda
- Bendamustinum
- Bendamustinhydrochlorid
- BendaMustin HCl
- SDX 105
- 4-(5-(bis(2-chloroethyl)aMino)-1-Methyl-1H-benzo[d]iMidazol-2-yl)butanoic acid hydrochloride
- BendaMustine HCl USP
- Bendamustine HCl(SDX-105)
- 5-[bis(2-chloroethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid,hydrochloride (1:1)
- SDX-105 (Cytostasane) HCl
- 1H-Benzimidazole-2-butanoic acid, 5-[bis(2-chloroethyl)amino]-1-methyl monohydrochloride
- EP3101
- bendamustine HCl API
- Bendamustine (SDX-105) HCl
- Bendamustine hydrochloride, 98%, a DNA-damaging agent
- Bendamustine (SDX-105) hydrochloride
- Cytostasane
- Bendamustine Hydrochloride Hydrate>
- Bendamustine Hydrochloride (200 mg)
- 5-[Bis(2-chloroethyl)amino]-1-methylbenzimidazole-2-butyric Acid Hydrochloride
- Bendamustine hydrochloride USP/EP/BP
- Bendamustine API& intermediates
- Bendamustine HydrochlorideQ: What is
Bendamustine Hydrochloride Q: What is the CAS Number of
Bendamustine Hydrochloride Q: What is the storage condition of
Bendamustine Hydrochloride Q: What are the applications of
Bendamustine Hydrochloride
- Bendamustine Hydrochloride (1065221)
- Bendamustine HCI
- Bendamustine hydrochloride hcl
- Bendamustine hydrochloride(1:1)
- Bendamustine hydrochloride, DNA alkylating agent
- Bendamustine hydrochloride, 10 mM in DMSO
- Bendamustine HCl - Bio-X ?
- BendaMustine hydrochloride hydrate
- BENDAMUSTINE HCL
- 3543-75-7
- C16H213N3O2HCl
- C16H22Cl3N3O2
- C16H21Cl2N3O2HClxH2O
- C16H21Cl2N3O2ClHH2O
