7H-Furo(3',2',:4,5)furo-(2,3-c)xanthen-7-on, 3a,12c-dihydro-8-hydroxy-6-methoxy-,(3aR-cis)- Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R25:Giftig beim Verschlucken.
R40:Verdacht auf krebserzeugende Wirkung.
S-Sätze Betriebsanweisung:
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Beschreibung
Sterigmatocystin is a mycotoxin that has been found in
Aspergillus. It is lethal to rats (LD
50 = 60 mg/kg) and chick embryos (LD
50s = 5-7 μg/embryo). Sterigmatocystin (100 and 1,000 ppb in drinking water) induces gastritis, as well as intestinal polyp formation and metaplasia in aged Mongolian gerbils. It induces formation of lung and liver adenomas and malignant lymphomas in newborn mice.
Chemische Eigenschaften
yellow needles or powder
Verwenden
Sterigmatocystin is a carcinogenic mycotoxin that is struturally related to Aflatoxin. Sterigmatocystin has been shown to inhibit RNA synthesis in rat liver nuclei.
Definition
ChEBI: An organic heteropentacyclic compound whose skeleton comprises a xanthene ring system ortho-fused to a dihydrofuranofuran moiety. The parent of the class of sterigmatocystins.
Hazard
Possible carcinogen; tumorigen; poison;
mutagen; causes necrosis of the liver and kidney,
and an inhibitory effect on orotic acid incorporation
into nuclear RNA.
Sicherheitsprofil
Confirmed carcinogen with experimental carcinogenic and tumorigenic data. Poison by ingestion and intraperitoneal routes. Human mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.
läuterung methode
It crystallises from amyl acetate, Me2CO or EtOH and sublimes in vacuo. It has UV max at 208, 235, 249 and 329nm (log 4.28, 4.39, 4.44 and 4.12). [UV: Bullock et al. J Chem Soc 4179, 1962, UV, IR: Holker & Mulheirn J Chem Soc, Chem Commun 1576, 1576 1968, Birkinshaw & Hammady Biochem J 65 162 1957.] This mycotoxin induces bone marrow changes in mice [Curry et al. Mutation Res 137 111 1984]. [Beilstein 19/10 V 575.]
7H-Furo(3',2',:4,5)furo-(2,3-c)xanthen-7-on, 3a,12c-dihydro-8-hydroxy-6-methoxy-,(3aR-cis)- Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
