N-(3-OXOOCTANOYL)-L-HOMOSERINE LACTONE Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density. This regulatory process manifests itself with a variety of phenotypes including biofilm formation and virulence factor production. Coordinated gene expression is achieved by the production, release, and detection of small diffusible signal molecules called autoinducers. The N-
acylated homoserine lactones (AHLs) comprise one such class of autoinducers, each of which generally consists of a fatty acid coupled with homoserine lactone (HSL). Regulation of bacterial quorum sensing signaling systems to inhibit pathogenesis represents a new approach to antimicrobial therapy in the treatment of infectious diseases. AHLs vary in acyl group length (C
4-
C
18), in the substitution of C3 (hydrogen, hydroxyl, or oxo group), and in the presence or absence of one or more carbon-
carbon double bonds in the fatty acid chain. These differences confer signal specificity through the affinity of transcriptional regulators of the LuxR family. In the gram-
negative bacterium
A. tumefaciens, N-
3-
oxo-
octanoyl-
L-
homoserine lactone promotes the expression of the transcriptional activator (and LuxR homolog) TraR.
Verwenden
N-3-oxo-octanoyl-L-Homoserine lactone is a reagent that promotes the expression of the transcriptional activator.
Allgemeine Beschreibung
N-(3-Oxooctanoyl)-L-homoserine lactone is a common quorum sensing (QS) signal.
N-(3-OXOOCTANOYL)-L-HOMOSERINE LACTONE Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
