oestriol Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R60:Kann die Fortpflanzungsfähigkeit beeinträchtigen.
R61:Kann das Kind im Mutterleib schädigen.
R40:Verdacht auf krebserzeugende Wirkung.
R45:Kann Krebs erzeugen.
S-Sätze Betriebsanweisung:
S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
S22:Staub nicht einatmen.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
Beschreibung
Estriol is significantly less active than estradiol; however, it has a selective ability to stimulate
blood flow and restoration of genital epithelium. In addition, using this drug reduces
mental symptoms of menopausal syndrome. It is used in the premenopausal and
menopausal periods, for skin atrophy and signs of genital degeneration, and so on.
Chemische Eigenschaften
White or almost white, crystalline powder.
Verwenden
A metabolite of Estradiol. An estrogenic metabolite considerably less potent than the hormone Estradiol
Definition
ChEBI: A 3-hydroxy steroid that is estra-1,3,5(10)-trien-3-ol substituted by additional hydroxy groups at positions 16 and 17 (16alpha,17beta-stereoisomer).
Allgemeine Beschreibung
Estriol, estra-1,3,5(10)-triene-3,16 ,17 -triol, is available for compounding into several differentformulations for use in HRT. It can be used alone or in combinationswith estradiol (Bi-Est) or with estradiol and estrone(Tri-Est).
Hazard
A carcinogen (OSHA).
Sicherheitsprofil
Suspected carcinogen
with experimental carcinogenic,
neoplastigenic, tumorigenic, and teratogenic
data. Other experimental reproductive
effects. Mutation data reported. A steroid
drug for the treatment of menopause. When
heated to decomposition it emits acrid
smoke and irritating fumes.
läuterung methode
Crystallise estriol from EtOH/ethyl acetate. Also purify it by countercurrent distribution with cyclohexane/EtOAc (1:1) and EtOH/H2O (1:1). The UV (EtOH) has max at 280nm ( 2,090 M-1cm-1). [Huffmann & Lott 71 719 1949, Leeds et al. J Am Chem Soc 76 2943 1954, Beilstein 6 IV 7550.]
oestriol Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Estron
2,4-Dibromo-β-D-Glucopyranosiduronic Acid Estrane Derivative
3,16α-Dihydroxyestra-1,3,5(10)-trien-17-on-3,16-diacetat
16α,17α-Epoxy-1,3,5(10)-estratriene-3,17β-diol diacetate
1,3,5[10]-ESTRATRIENE-3,16ALPHA-DIOL-17-ONE
Epiestriol
2,4,16a-Tribromoestrone
2,4-Dibromo-16a-hydroxyestrone
Estra-1,3,5(10),16-tetraen-3,17-dioldiacetat
17-BETA-ESTRADIOL 3-METHYL ETHER
Downstream Produkte
