Roxithromycin
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- CAS-Nr.
- 80214-83-1
- Englisch Name:
- Roxithromycin
- Synonyma:
- Roxid;Rulid;Roxithromycin (Roxl-150);Roxithromycin Solution, 100ppm;Brilid;Overal;RU 965;Surlid;Assoral;Forilin
- CBNumber:
- CB1707342
- Summenformel:
- C41H76N2O15
- Molgewicht:
- 837.05
- MOL-Datei:
- 80214-83-1.mol
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Roxithromycin Eigenschaften
- Schmelzpunkt:
- 111-118C
- Siedepunkt:
- 864.7±75.0 °C(Predicted)
- alpha
- D25 -77.5 ±2° (c = 0.45 in chloroform)
- Dichte
- 1.25±0.1 g/cm3(Predicted)
- Flammpunkt:
- >110°(230°F)
- storage temp.
- Sealed in dry,2-8°C
- Löslichkeit
- chloroform: soluble10mg/mL
- pka
- pKa 9.27±0.01(H2O
t = 25.0
I = 0.15 (KCl)) (Uncertain)
- Aggregatzustand
- powder
- Farbe
- White to off-white
- Wasserlöslichkeit
- Soluble in water to 18µg/ml
- Merck
- 14,8276
- Major Application
- pharmaceutical (small molecule)
- InChIKey
- RXZBMPWDPOLZGW-HEWSMUCTSA-N
- SMILES
- CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)C(C)O2)C(C)C(OC3OC(C)CC(C3O)N(C)C)C(C)(O)CC(C)C(=N/OCOCCOC)\C(C)C(O)C1(C)O
- CAS Datenbank
- 80214-83-1
- EPA chemische Informationen
- Erythromycin, 9-[O-[(2-methoxyethoxy)methyl]oxime], (9E)- (80214-83-1)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Kennzeichnung gefährlicher |
Xn |
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| R-Sätze: |
22 |
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| S-Sätze: |
26-24/25 |
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| WGK Germany |
3 |
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| RTECS-Nr. |
KF4990000 |
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| HS Code |
29415000 |
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| Speicherklasse |
11 - Combustible Solids |
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| Hazard Classifications |
Acute Tox. 4 Oral |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitsschädlich bei Verschlucken. |
Akute Toxizität oral |
Kategorie 4 |
Warnung |
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P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P301+P312 |
BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P501 |
Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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Roxithromycin Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Beschreibung
Roxithromycin, an oxime ether derivative of erythromycin, is a new macrolide antibiotic
of high potency and long duration. Its in v i m activity spectrum is similar to that of
erythromycin, but is superior to the latter against Legionella, Mycoplasma and Chlamydia.
Chemische Eigenschaften
White Solid
Verwenden
Roxithromycin was one of the new generation erythromycins introduced in the 1980s. Improved acid stability was achieved by converting the 9-keto group to the more stable oxime and alkylation of the oxime to provide the methoxyethoxymethyl ether oxime. In vivo, roxithromycin exhibits higher tissue levels and a longer half-life while being slightly less potent than erythromycin in vitro.
Antimicrobial activity
Activity against common pathogens is comparable to that of erythromycin. It is active against L. monocytogenes, C. jejuni, H. ducreyi, G. vaginalis, Bord. pertussis, C. diphtheriae, B. burgdorferi, H. pylori, the M. avium complex, Chlamydia spp., and U. urealyticum.
Pharmazeutische Anwendungen
A semisynthetic derivative of erythromycin A formulated for oral use.
Nebenwirkungen
It is generally well tolerated, adverse effects being described in 3–4% of patients, mostly gastrointestinal disturbance (abdominal pain, nausea and diarrhea). Headache, weakness, dizziness, rash and reversible changes in liver function tests and increased eosinophils and platelets have also been described.
Roxithromycin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Roxithromycin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 671)Lieferanten
80214-83-1()Verwandte Suche:
- ROXITHROMYCIN
- Roxithromycin CP2000
- ERYTHROMYCIN 9-(-O-[2-METHOXYETHOXY]METHYLOXIME)
- ERYTHROMYCIN, 9-[O-[(2-METHOXYETHOXY)METHYL]OXIME], (9E)-
- Roxithromycin EP
- RoxithromycinEp/Bp/CpC41H76N2O15
- RoxithromycinC41H76N2O15
- (9E)-9-[O-[(2-Methoxyethoxy)methyl]oxime] Erythromycin
- Assoral
- Roxl-150
- Roxithromycin Solution, 100ppm
- 10% water-soluble roxithromycin
- Roxithromycin solution,1000ppm
- ROM erythromycin(Water soluble)
- 70% water-soluble roxithromycin
- Roxithromycin id
- (3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-6-[[4-(dimethylamino)-3-hydroxy-6-methyl-2-oxanyl]oxy]-14-ethyl-7,12,13-trihydroxy-4-[(5-hydroxy-4-methoxy-4,6-dimethyl-2-oxanyl)oxy]-10-(2-methoxyethoxymethoxy
- (E)-roxithromycin
- Brilid
- Claramid
- Forilin
- Overal
- Rossitrol
- Rotramin
- Roxeptin
- Roxid
- Roxithromycin A
- RU 28965
- RU 965
- Rulid
- Surlid
- biaxsig
- ROXITHROMYCIN,BP,EP
- Erythromycin, 9-[O-[(2-methoxyethoxy)methyl]oxime], (9E)- (9CI)
- 5-(3,4,6-Trideoxy-3-dimethylamino-beta-D-xylo-hexopyranosyloxy)-3-(2,6-dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyloxy)-6,11,12-trihydroxy-9-(2-methoxyethoxy)methoxyimino-2,4,6,8,10,12-hexamethylpentadecan-13-olide
- water-soluble roxithromycin70%
- aaram．D．Forilin
- 9-[O-(2-Methoxyethoxy)methyloxime]erythromycin
- 9-Deoxo-9-[(2-methoxyethoxy)methoxyimino]erythromycin
- 9-Deoxo-9-[[(2-methoxyethoxy)methyl]oxyimino]erythromycin
- Roxithromycin,Erythromycin 9-(-O-[2-methoxyethoxy]methyloxime)
- (3R,4S,5S,6R,7R,9R,11S,12R,13S,14R)-6-{[(2S,3R,4S,6R)-4-(diMethylaMino)-3-hydroxy-6-Methyloxan-2-yl]oxy}-14-ethyl-7,12,13-trihydroxy-4-{[(2R,4R,5S,6S)-5-hydroxy-4-Methoxy-4,6-diMethyloxan-2-yl]oxy}-3,5,7,9,11,13-hexaMethyl-10-(2,4,7-trioxa-1-azaoctan-1-yl
- RoxithroMycin API
- Roxithromycin CRS
- Roxithromycin for system suitability CRS
- (3R,4S,5S,6R,7R,9R,11S,12R,13S,14R,E)-6-(((2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-14-ethyl-7,12,13-trihydroxy-4-(((2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-10-(((2-methoxyethoxy)methoxy)imino)-3,5,7,9,11,13-hexamethyloxacyclotetradecan-2-one
- Roxithromycin USP/EP/BP
- Roxithromycin (1.0 mg/mL in Methanol)
- (3R,4S,5S,6R,7R,9R,11S,12R,13S,14R,E)-6-(((2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-14-ethyl-7,12,13-trihydroxy-4-(((2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-10-(((2-methoxyethoxy)met
- Roxithromycin-13CD3
- RoxithromycinQ: What is
Roxithromycin Q: What is the CAS Number of
Roxithromycin Q: What is the storage condition of
Roxithromycin Q: What are the applications of
Roxithromycin
- Oxithromycin
- Roxithromycin in Methanol
- C16860000 Roxithromycin
- Roxithromycin 100 μg/ml Methanol
- Roxithromycin, 10 mM in DMSO
- Roxithromycin RS
- Roxithromycin 100 μg/mL in Acetonitrile
