Mirogabalin

1138245-13-2

CAS-Nr.: 1138245-13-2

Englisch Name:: Mirogabalin

Synonyma:: Asapiprant;2-((1R,5S,6S)-6-(aminomethyl)-3-ethylbicyclo[3.2.0]hept-3-en-6-yl)acetic acid;DS5565;A200-0700;Milobarin;mirobalin;Miluobalin;Mirogabalin;Mirogabalin HCl;DS5565;A200-0700

CBNumber:: CB23051612

Summenformel:: C12H19NO2

Molgewicht:: 209.28

MOL-Datei:: 1138245-13-2.mol

Request For Quotation

Eigenschaften Sicherheit Verwendungswort Produktionsfirma 217

Mirogabalin Eigenschaften

Siedepunkt:: 357.5±15.0 °C(Predicted)

Dichte: 1.104±0.06 g/cm3(Predicted)

storage temp.: Store at -20°C

Löslichkeit: DMF:0.5(Max Conc. mg/mL);2.39(Max Conc. mM)
Ethanol:1.25(Max Conc. mg/mL);5.97(Max Conc. mM)
PBS (pH 7.2):0.5(Max Conc. mg/mL);2.39(Max Conc. mM)
Water:5.36(Max Conc. mg/mL);25.61(Max Conc. mM)

Aggregatzustand: A crystalline solid

pka: 4.65±0.10(Predicted)

Farbe: Light yellow to light brown

InChI: InChI=1S/C12H19NO2/c1-2-8-3-9-5-12(7-13,6-11(14)15)10(9)4-8/h4,9-10H,2-3,5-7,13H2,1H3,(H,14,15)/t9-,10-,12-/m1/s1

InChIKey: FTBQORVNHOIASH-CKYFFXLPSA-N

SMILES: [C@]12([H])[C@]([H])([C@@](CN)(CC(O)=O)C1)C=C(CC)C2

Sicherheit

Risiko- und Sicherheitserklärung
Gefahreninformationscode (GHS)

Bildanzeige (GHS)

Alarmwort

Warnung

Gefahrenhinweise

Code	Gefahrenhinweise	Gefahrenklasse	Abteilung	Alarmwort	Symbol	P-Code
H302	Gesundheitsschädlich bei Verschlucken.	Akute Toxizität oral	Kategorie 4	Warnung	src="/GHS07.jpg" width="20" height="20" />	P264, P270, P301+P312, P330, P501
H315	Verursacht Hautreizungen.	Hautreizung	Kategorie 2	Warnung	src="/GHS07.jpg" width="20" height="20" />	P264, P280, P302+P352, P321,P332+P313, P362
H319	Verursacht schwere Augenreizung.	Schwere Augenreizung	Kategorie 2	Warnung	src="/GHS07.jpg" width="20" height="20" />	P264, P280, P305+P351+P338,P337+P313P
H335	Kann die Atemwege reizen.	Spezifische Zielorgan-Toxizität (einmalige Exposition)	Kategorie 3 (Atemwegsreizung)	Warnung	src="/GHS07.jpg" width="20" height="20" />

Sicherheit

P261	Einatmen von Staub vermeiden.
P305+P351+P338	BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

Mirogabalin Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Mirogabalin is a calcium channel blocker with analgesic effects. It binds to the α₂δ-1 and α₂δ-2 subunits of voltage-dependent Ca²⁺ channels. Mirogabalin has potent and sustained analgesic effects (ED₅₀ = 2.5 mg/kg) in rats with diabetes induced by streptozotocin (STZ; ). Mirogabalin does not inhibit activities associated with CNS adverse effects of analgesics, such as rotarod performance (ID₅₀ = 9.4 mg/kg) or locomotor activity (ID₅₀ = 43.9 mg/kg), at its effective dose. Formulations containing mirogabalin are in clinical trials for diabetic peripheral neuropathic pain.

Verwenden

Mirogabalin is a two alpha2delta ligand which is investigated for the treatment of peripheral neuropathic pain, postherpetic neuralgia and fibromyalgia, showing promising results in patients with diabetic peripheral neuropathy.

Trademarks

Mirogabalin (brand name Tarlige; developmental code name DS-5565) is a gabapentinoid medication developed by Daiichi Sankyo.

Mirogabalin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

tert-butyl 2-((1R,5S,6S)-6-(((tert-butoxycarbonyl)amino)methyl)-3-ethylbicyclo[3.2.0]hept-3-en-6-yl)acetate Hydrogenchlorid N,N-Diethylethanamin Ethylacetat Dichlormethan

Downstream Produkte

Mirogabalin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 217)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Beijing Hope Pharmaceutical Co., Ltd.	+86-010-67886402 +8613611125266	market@hopelife.cn	China	72	58
Cangzhou Kangrui Pharma Tech Co. Ltd.,	+86-18632776803 +86-13833998158	cangzhoukangrui@126.com	China	773	58
Hebei Junhua Import and Export Co., LTD	+85259680964	junhua1@hb-junhua.com	China	933	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19552	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-81139210 +86-18192627656	1059@dideu.com	China	3586	58
Hebei Yanxi Chemical Co., Ltd.	+8618531123677	faithe@yan-xi.com	China	5853	58
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32432	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6312	58
AFINE CHEMICALS LIMITED	+86-0571-85134551	sales@afinechem.com	China	15144	58

2-((1R,5S,6S)-6-(aminomethyl)-3-ethylbicyclo[3.2.0]hept-3-en-6-yl)acetic acid
Mirogabalin
Asapiprant
[(1R,5S,6S)-6-(Aminomethyl)-3-ethylbicyclo[3.2.0]hept-3-en-6-yl]acetic acid
A200-0700
DS5565
DS5565;A200-0700
2-[(1R,5S,6S)-6-(aminomethyl)-3-ethyl-6-bicyclo[3.2.0]hept-3-enyl]acetic acid
MIROGABALIN; DS-5565
DS 5565;DS-5565;DS5565
Bicyclo[3.2.0]hept-3-ene-6-acetic acid, 6-(aminomethyl)-3-ethyl-, (1R,5S,6S)-
Miluobalin
Mirogabalin HCl
Milobarin
mirobalin
Mirogabalin free base
Mirogabalin Impurity
Mirogabalin base
Mirogabalin Impurity 65
Mirogabalin Impurity 35 Hydrochloride
Mirogabalin Impurity 13 Hydrochloride
Mirogabalin-d2,15N
Mirogabalin Impurity 18 Hydrochloride
Mirogabalin Impurity 151
Mirogabalin Impurity 156
Mirogabalin Impurity 157
Mirogabalin Impurity 158
Mirogabalin Impurity 5 Acetate
Mirogabalin Impurity 153
Mirogabalin Impurity 154
Mirogabalin Impurity 67
Mirogabalin Impurity 84
Mirogabalin Impurity 85
Mirogabalin Impurity 86
Mirogabalin Impurity 87
Mirogabalin Impurity 4 Monomer
Mirogabalin Impurity 88
Mirogabalin Impurity 89
Mirogabalin Impurity 90
Mirogabalin Impurity 76
Mirogabalin Impurity 78
Mirogabalin Impurity 80
Mirogabalin Impurity 6 Maleate
Mirogabalin Impurity 81
Mirogabalin Impurity 82
Mirogabalin Impurity 93
Mirogabalin Impurity 95
Mirogabalin Impurity 150
Mirogabalin Impurity 98
Mirogabalin Impurity 99
Mirogabalin Impurity 100
Mirogabalin Impurity 101
Mirogabalin Impurity 140
Mirogabalin Impurity 141
Mirogabalin Impurity 142
Mirogabalin Impurity 143
Mirogabalin Impurity 144
Mirogabalin Impurity 145