Metacyclinhydrochlorid
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- CAS-Nr.
- 3963-95-9
- Bezeichnung:
- Metacyclinhydrochlorid
- Englisch Name:
- Metacycline hydrochloride
- Synonyma:
- METACYCLINE;METHACYCLINE HYDROCHLORIDE;METHACYCLINE HCL;adriamicina;METACYCLINE HCL;optimycin;MethacycL;metadomus;londomycin;megamycine
- CBNumber:
- CB2355197
- Summenformel:
- C22H23ClN2O8
- Molgewicht:
- 478.88
- MOL-Datei:
- 3963-95-9.mol
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Metacyclinhydrochlorid Eigenschaften
- Schmelzpunkt:
- >224°C(dec.)
- storage temp.
- Inert atmosphere,Room Temperature
- Löslichkeit
- DMSO (Slightly, Heated), Methanol (Slightly, Heated, Sonicated), Water (Slightly)
- Aggregatzustand
- Crystalline Powder
- Farbe
- Yellow
- BRN
- 5470951
- Major Application
- pharmaceutical (small molecule)
- InChIKey
- VZQARNDJLLWXGL-ATGQEJIKNA-N
- SMILES
- O[C@@]12C(C(C(=O)N)=C(O)[C@@H](N(C)C)[C@]1([H])[C@H]([C@]1([H])C(C3C=CC=C(O)C=3C(=O)C1=C2O)=C)O)=O.Cl |&1:1,9,13,15,16,r|
- CAS Datenbank
- 3963-95-9
- EPA chemische Informationen
- Methacycline hydrochloride (3963-95-9)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| S-Sätze: |
24/25-22 |
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| WGK Germany |
2 |
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| RTECS-Nr. |
QI9276000 |
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| HS Code |
29413020 |
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| Speicherklasse |
11 - Combustible Solids |
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| Toxizität |
LD50 in rats, mice (mg/kg): 252, 288 i.p. (Goldenthal) |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
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P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
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P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizität (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
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| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P302+P352 |
BEI BERÜHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckmäßig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen. |
| P321 |
Besondere Behandlung |
| P332+P313 |
Bei Hautreizung: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen. |
| P362 |
Kontaminierte Kleidung ausziehen und vor erneutem Tragen waschen. |
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Metacyclinhydrochlorid Chemische Eigenschaften,Einsatz,Produktion Methoden
S-Sätze Betriebsanweisung:
S24/25:Berührung mit den Augen und der Haut vermeiden.
S22:Staub nicht einatmen.
Beschreibung
Methacycline is a tetracycline-class antibiotic that is active against a wide range of Gram-positive and Gram-negative organisms. It is readily absorbed from the gastrointestinal tract and reaches a maximum concentration at about the fourth hour, declining to a negligible amount in about 24 hours. It is more active than tetracycline against a number of bacteria.
Chemische Eigenschaften
yellow crystalline powder
Verwenden
Broad spectrum, semisynthetic antibiotic related to Tetracycline. Antibacterial.
Allgemeine Beschreibung
The synthesis of methacycline, 6-deoxy-6-demethyl-6-methylene-5-oxytetracycline hydrochloride (Rondomycin), reportedby Blackwood et al. in 1961, was accomplished bychemical modification of oxytetracycline. It has an antibioticspectrum like that of the other tetracyclines but greater potency;about 600 mg of methacycline is equivalent to 1 g oftetracycline. Its particular value lies in its longer serum halflife;doses of 300 mg produce continuous serum antibacterialactivity for 12 hours. Its toxic manifestations and contraindicationsare similar to those of the other tetracyclines.
The greater stability of methacycline, both in vivo and invitro, results from modification at C-6. Removal of the 6-hydroxy group markedly increases the stability of ring C toboth acids and bases, preventing the formation of isotetracyclinesby bases. Anhydrotetracyclines still can form, however,by acid-catalyzed isomerization under strongly acidicconditions. Methacycline hydrochloride is a yellow to darkyellow, crystalline powder that is slightly soluble in waterand insoluble in nonpolar solvents. It should be stored intight, light-resistant containers in a cool place.
Metacyclinhydrochlorid Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Metacyclinhydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 307)Lieferanten
3963-95-9(Metacyclinhydrochlorid)Verwandte Suche:
- Methacycline HCl (PhysioMycine)
- Rondomycin hydrochloride
- 6-Methyleneoxytetracycline hydrochloride, Metacycline hydrochloride, LondoMycin
- (4S,4aR,5S,5aR,12aS)- 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methylene-1,11-dioxo-2-naphthacenecarboxamide, hydrochloride (1:1)
- Methacycline hydrochloride Solution, 100ppm
- Hydrochloric acid methacycline
- 6-DEMETHYL-6-DEOXY-6-METHYLENEOXYTETRACYCLINE MONOHYDROCHLORIDE
- 6-DEMETHYL-6-DEOXY-6-METHYLENEOXYTETRACYCLNE HYDROCHLORIDE
- METACYCLINE HCL
- METACYCLINE HYDROCHLORIDE
- METHACYCLINE HCL
- 12,12a-pentahydroxy-6-methylene-1,11-dioxo-1monohydrochloride
- metilenbiotic
- optimycin
- physiomycine
- Metacycline hydrochloride, sec. Standard, 98%
- 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methylene-1,11-dioxo-, monohydrochloride, (4S,4aR,5S,5aR,12aS)-
- METHACYCLINE HYDROCHLORIDE (METACYCLINE HYDROCHLORIDE)
- METACYCLINE HYDROCHLORIDE, 98%, SEC. STANDARD
- MethacycL
- Methacycline hydrochlorid
- 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methylene-1,11-dioxo-, monohydrochloride
- Metacycline, Adramycin, Rondomycin, Pindex
- Methacycline hydrochloride, potency: 877 u/mg
- Metacylcline HLC
- (4S,4aR,5S,5aR,12aS)-4-(DiMethylaMino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-Methylene-1,11-dioxo-2-naphthacenecarboxaMide HCl
- Methacycline hydrochloride (PhysioMycine)
- ciclobiotic
- germiciclin
- globociclina
- londomycin
- megamycine
- metadomus
- methacyclinemonohydrochloride
- Metacyclin hydrochloride
- Methacycline Hydrochloride (200 mg)
- Methacycline Hydrochloride (200 mg)I0C348903ug/mg(ai)
- Metacycline hydrochloride USP/EP/BP
- (4S,4aR,5S,5aR,12aS)-4-(Dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methylene-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide hydrochloride
- Methacycline HydrochlorideQ: What is
Methacycline Hydrochloride Q: What is the CAS Number of
Methacycline Hydrochloride Q: What is the storage condition of
Methacycline Hydrochloride Q: What are the applications of
Methacycline Hydrochloride
- Metacyclinhydrochlorid
- Methacycline Hydrochloride (1397006)
- Doxycycline EP Impurity B / Methacycline Impurity
- Doxycycline Hyclate Impurity B as Hydrochloride
- Doxycycline Hyclate EP Impurity B as Hydrochloride
- (4S,4Ar,5S,5aR,12aS)-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methylidene-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide
- Doxycycline EP Impurity B（HCl）
- Methicycline hydrochloride
- Methacylcycline Hydrochloride
- C14917000 MetacyclinEhydrochloride
- Methacycline hydrochloride 100 μg/ml Acetonitrile
- Methacycline hydrochloride, 10 mM in DMSO
- DOXYCYCLINE EP IMPURITY B (METHACYCLINE HCL)
- Metacycline hydrochloride 100 μg/mL in Acetonitrile
- Metacycline hydrochloride RS
- Methacycline hydrochloride (Standard)
- adriamicina
- METACYCLINE
