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Pomalidomide-PEG1-azide

2133360-04-8

CAS-Nr.: 2133360-04-8

Englisch Name:: Pomalidomide-PEG1-azide

Synonyma:: N3-PEG1-CH2CO-Poma;Pomalidomide-PEG1-azide;Pomalidomide-NH-CO-PEG1-N3;2-(2-Azidoethoxy)-N-[2-(2,6-dioxo-3-piperidyl)-1,3-dioxoisoindolin-4-yl]acetamide;2-(2-azidoethoxy)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)acetamide;2-(2-Azidoethoxy)-N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]acetamide;Acetamide, 2-(2-azidoethoxy)-N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-;2-(2-Azidoethoxy)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)acetamide?, Pomalidomide-PEG1-azide;Pomalidomide-PEG1-azide/Acetamide,2-(2-azidoethoxy)-N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-

CBNumber:: CB24813989

Summenformel:: C17H16N6O6

Molgewicht:: 400.35

MOL-Datei:: 2133360-04-8.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 25

Pomalidomide-PEG1-azide Eigenschaften

storage temp.: 2-8°C

Löslichkeit: DMSO : 62.5 mg/mL (156.11 mM; ultrasonic and warming and heat to 60°C)

Aggregatzustand: Solid

Farbe: Light yellow to yellow

InChIKey: SKTGGMFEGRISBY-UHFFFAOYSA-N

SMILES: O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NC(COCCN=[N+]=[N-])=O)=O)NC1=O

Sicherheit

WGK Germany	WGK 3
Speicherklasse	11 - Combustible Solids

Pomalidomide-PEG1-azide Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Protein degrader builiding block Pomalidomide-PEG1-azide enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant azide for click chemistry with a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation When used with other protein degrader building blocks with a pendant azide group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

Pomalidomide-PEG1-azide Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Pomalidomide-PEG1-azide Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 25)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
TargetMol Chemicals Inc.	+1-781-999-5354; +1-00000000000	marketing@targetmol.com	United States	32431	58
BOC Sciences	16314854226; +8616314854226	inquiry@bocsci.com	United States	19852	58
Xian confluore Biological Technology Co., Ltd.	+86-15680926068	1924344760@confluore.cn	China	3000	58
Aladdin Scientific		tp@aladdinsci.com	United States	54746	58
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51389	80
Shanghai YuanYe Biotechnology Co., Ltd.	13636370518	shyysw007@163.com	China	89667	60
Shanghai Chaolan Chemical Technology Center	QQ：65489617 13301690235	Sales@ATKchemical.com	China	9696	58
Xi'an Confluore Biological Technology Co., Ltd.	+86-156-80926068 +86-15680926068	1924344760@qq.com	China	4229	58
Jilin Province Woda Biotechnology Co., Ltd.	13504435624	1927928688@qq.com	China	1644	58
Changsha Bono New Materials Technology Co., Ltd.	18191076804	asherw9@hotmail.com	China	2373	58

Pomalidomide-PEG1-azide
Pomalidomide-NH-CO-PEG1-N3
2-(2-Azidoethoxy)-N-[2-(2,6-dioxo-3-piperidyl)-1,3-dioxoisoindolin-4-yl]acetamide
N3-PEG1-CH2CO-Poma
Acetamide, 2-(2-azidoethoxy)-N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-
2-(2-Azidoethoxy)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)acetamide?, Pomalidomide-PEG1-azide
Pomalidomide-PEG1-azide/Acetamide,2-(2-azidoethoxy)-N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-
2-(2-Azidoethoxy)-N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]acetamide
2-(2-azidoethoxy)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)acetamide
2133360-04-8
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