Dimetotiazin

Dimetotiazine Struktur
7456-24-8
CAS-Nr.
7456-24-8
Bezeichnung:
Dimetotiazin
Englisch Name:
Dimetotiazine
Synonyma:
8599RP;Fonazine;Bayer 1483;Dimethodin;Brn 0941549;Dimetiotazine;Dimetotiazine;Dimetothiazine;Dimethiotazine;Dimethothiazine
CBNumber:
CB2875673
Summenformel:
C19H25N3O2S2
Molgewicht:
391.557
MOL-Datei:
7456-24-8.mol

Dimetotiazin Eigenschaften

Siedepunkt:
533.7±60.0 °C(Predicted)
Dichte
1.1822 (rough estimate)
Brechungsindex
1.6560 (estimate)
pka
8.91±0.50(Predicted)

Sicherheit

Dimetotiazin Chemische Eigenschaften,Einsatz,Produktion Methoden

Originator

Migristene,Rhone Poulenc,France,1965

Verwenden

Serotonin inhibitor.

Manufacturing Process

A solution of 3-dimethylsulfamoylphenthiazine (10 grams) in xylene (100 cc) is heated under reflux for 3 hours with sodium amide (1.5 grams). A solution of 1-dimethylamino-2-chloropropane (4.4 grams) in anhydrous xylene (30 cc) is then added and heating under reflux continued for 4 hours. After cooling the suspension obtained is agitated with water (50 cc) and ether (30 cc). The aqueous layer is separated and the basic products are extracted from the organic phase with 10% hydrochloric acid. The xylene layer is discarded and, after the combined acid solutions have been made alkaline with sodium carbonate, the base is extracted with chloroform. The chloroform solutions are then washed with water and dried over anhydrous potassium carbonate. After evaporation of the solvent under reduced pressure there is obtained a crude resinous base (9.7 grams).
On the addition of ethereal hydrogen chloride to a solution of the base in isopropanol and recrystallization from anhydrous ethanol of the salt formed, there is obtained 3-dimethylsulfamoyl-10-(2-dimethylaminopropyl) phenthiazine hydrochloride (2.1 grams), MP 214°C with decomposition. After dissolving the product in anhydrous ethanol and adding methanesulfonic acid there is obtained fonazine mesylate.

Dimetotiazin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Dimetotiazin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 11)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Shaanxi Dideu Medichem Co. Ltd
+8617392709771
1097@dideu.com China 3992 58
Shaanxi Dideu Medichem Co. Ltd
+86-29-87569262 +86-15003564040
1056@dideu.com China 3970 58
BOC Sciences
16314854226; +16314854226
inquiry@bocsci.com United States 19853 58
TargetMol Chemicals Inc.
+1-781-999-5354;
support@targetmol.com United States 39040 58
TargetMol Chemicals Inc.
+17819995354
marketing@targetmol.com United States 19956 58
DAYANG CHEM (HANGZHOU) CO.,LTD
+86-88938639 +86-17705817739
info@dycnchem.com China 53803 58
LGM Pharma 1-(800)-881-8210
inquiries@lgmpharma.com United States 2123 70
Aribo Pharmatech Co., Ltd. 19951442182
sales@aribopharm.com China 1748 58
TargetMol Chemicals Inc. 15002134094
marketing@targetmol.cn China 29867 58

7456-24-8(Dimetotiazin)Verwandte Suche:


  • Dimetotiazine
  • 10-(2-dimethylaminopropyl)-N,N-dimethyl-phenothiazine-2-sulfonamide: m ethanesulfonic acid
  • 10-[2-(Dimethylamino)propyl]-N,N-dimethylphenothiazine-2-sulfonamide
  • 10H-Phenothiazine-2-sulfonamide, 10-[2-(dimethylamino)propyl]-N,N-dimethyl-
  • Dimethiotazine
  • Dimethothiazine
  • Fonazine
  • Phenothiazine-2-sulfonamide, 10-[2-(dimethylamino)propyl]-N,N-dimethyl- (6CI, 7CI, 8CI)
  • Dimetiotazine
  • 8599RP
  • Dimetothiazine
  • N,N-Dimethyl-10-[2-(dimethylamino)propyl]-10H-phenothiazine-2-sulfonamide
  • 3-Dimethylsulfonamido 10-(2-dimethylaminopropyl)phenothiazine
  • Bayer 1483
  • Brn 0941549
  • Dimethodin
  • Dimethylsulfamido-3-(dimethylamino-2-propyl)-10-phenothiazine
  • Dimetotiazine USP/EP/BP
  • 7456-24-8
  • C20H29N3O5S3
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