2-[2-[4-[2-Methyl-3-(10H-phenothiazin-10-yl)propyl]piperazin-1-yl]ethoxy]ethanol
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- CAS-Nr.
- 2470-73-7
- Bezeichnung:
- 2-[2-[4-[2-Methyl-3-(10H-phenothiazin-10-yl)propyl]piperazin-1-yl]ethoxy]ethanol
- Englisch Name:
- 2-[2-[4-[2-methyl-3-(10H-phenothiazin-10-yl)propyl]piperazin-1-yl]ethoxy]ethanol
- Synonyma:
- Dixyrazine;Esucos;UCB-3412;Dixyrazine, 10 mM in DMSO;2-[2-[4-(2-methyl-3-phenothiazin-10-ylpropyl)piperazin-1-yl]ethoxy]ethanol;2-[2-[4-(2-methyl-3-phenothiazin-10-yl-propyl)piperazin-1-yl]ethoxy]ethanol;2-[2-[4-[2-Methyl-3-(10H-phenothiazin-10-yl)propyl]-1-piperazinyl]ethoxy]ethanol;2-[2-[4-[2-methyl-3-(10H-phenothiazin-10-yl)propyl]piperazin-1-yl]ethoxy]ethanol;Ethanol,2-[2-[4-[2-methyl-3-(10H-phenothiazin-10-yl)propyl]-1-piperazinyl]ethoxy]-;2-(2-(4-(2-Methyl-3-(10H-phenothiazin-10-yl)propyl)piperazin-1-yl)ethoxy)ethan-1-ol
- CBNumber:
- CB2901901
- Summenformel:
- C24H33N3O2S
- Molgewicht:
- 427.6
- MOL-Datei:
- 2470-73-7.mol
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2-[2-[4-[2-Methyl-3-(10H-phenothiazin-10-yl)propyl]piperazin-1-yl]ethoxy]ethanol Eigenschaften
- Schmelzpunkt:
- 192 °C
- Siedepunkt:
- 590.0±50.0 °C(Predicted)
- Dichte
- 1.0745 (rough estimate)
- Brechungsindex
- 1.6740 (estimate)
- storage temp.
- Store at -20°C
- Löslichkeit
- Soluble in DMSO
- pka
- pKa1: 7.8; pKa2: 3.65(at 25℃)
- Aggregatzustand
- Solid
- Farbe
- White to off-white
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
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P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
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P264, P280, P305+P351+P338,P337+P313P |
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| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P302+P352 |
BEI BERÜHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckmäßig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen. |
| P332+P313 |
Bei Hautreizung: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen. |
| P337+P313 |
Bei anhaltender Augenreizung: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen. |
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2-[2-[4-[2-Methyl-3-(10H-phenothiazin-10-yl)propyl]piperazin-1-yl]ethoxy]ethanol Chemische Eigenschaften,Einsatz,Produktion Methoden
Originator
Esucos,UCB Chemie,W. Germany,1962
Manufacturing Process
To a suspension of sodamide in liquid ammonia and made from sodium in
liquid ammonia, there is added fractionally and with stirring phenothiazine.
After an hour there is added thereto, while maintaining the stirring, 1-chloro-
2-methyl-3-bromopropane, then 700 cc of toluene. The ammonia is then
driven off and heating under reflux is carried out for one hour.
After cooling, water is added and the solution then decanted. The toluene
phase is then evaporated in vacuo to constant weight. The residue is
constituted of 10-(2-methyl-3-chloro-propyl)-phenothiazine containing acertain quantity of phenothiazine which has not reacted. As this product is not
readily soluble in petroleum ether, it is possible to eliminate it by extraction by
means of this solvent.
By operating in this manner 10-(2-methyl-3-chloro-propyl)phenothiazine is
obtained. A mixture of l0-(2-methyl-3-chloro-propyl)phenothiazine and 1-[2-
(2-hydroxyethoxy)ethyl]piperazine is then heated at 110°-120°C for 20 hours.
After cooling, the reaction product is dissolved in 200 cc of benzene and the
solution washed several times with water.
The benzene phase is then extracted by dilute hydrochloric acid. The acid
aqueous phase is decanted, it is made distinctly alkaline and then extracted
with benzene. The benzene extract is dried and evaporated in vacuo. The
condensation product could not be crystallized. It may be converted into the
dihydrochloride which, after recrystallization from isopropanol, melts at 192°C.
Therapeutic Function
Tranquilizer
2-[2-[4-[2-Methyl-3-(10H-phenothiazin-10-yl)propyl]piperazin-1-yl]ethoxy]ethanol Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
2-[2-[4-[2-Methyl-3-(10H-phenothiazin-10-yl)propyl]piperazin-1-yl]ethoxy]ethanol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 22)Lieferanten
2470-73-7(2-[2-[4-[2-Methyl-3-(10H-phenothiazin-10-yl)propyl]piperazin-1-yl]ethoxy]ethanol)Verwandte Suche:
- 2-[2-[4-[2-methyl-3-(10H-phenothiazin-10-yl)propyl]piperazin-1-yl]ethoxy]ethanol
- 2-[2-[4-[2-Methyl-3-(10H-phenothiazin-10-yl)propyl]-1-piperazinyl]ethoxy]ethanol
- Esucos
- UCB-3412
- 2-[2-[4-(2-methyl-3-phenothiazin-10-yl-propyl)piperazin-1-yl]ethoxy]ethanol
- 2-[2-[4-(2-methyl-3-phenothiazin-10-ylpropyl)piperazin-1-yl]ethoxy]ethanol
- Ethanol,2-[2-[4-[2-methyl-3-(10H-phenothiazin-10-yl)propyl]-1-piperazinyl]ethoxy]-
- Dixyrazine, 10 mM in DMSO
- 2-(2-(4-(2-Methyl-3-(10H-phenothiazin-10-yl)propyl)piperazin-1-yl)ethoxy)ethan-1-ol
- Dixyrazine
- 2470-73-7
- C24H33N3O2S
