Schisandrin

Schisandrin Struktur
7432-28-2
CAS-Nr.
7432-28-2
Englisch Name:
Schisandrin
Synonyma:
SCHISANDROL A;SCHIZANDRIN;SCHIZANDROL A;Schisandrol;SCHIZANDROL;12aR)-;schizandra;SCHISANDRIN;Schisadrol A;Schisandrinum
CBNumber:
CB3334838
Summenformel:
C24H32O7
Molgewicht:
432.51
MOL-Datei:
7432-28-2.mol

Schisandrin Eigenschaften

Schmelzpunkt:
128.5°C
Siedepunkt:
466.17°C (rough estimate)
Dichte
1.1480 (rough estimate)
Brechungsindex
1.5800 (estimate)
storage temp. 
2-8°C
Löslichkeit
DMSO: ≥13mg/mL
pka
14.58±0.40(Predicted)
Aggregatzustand
powder
Farbe
white to beige
Optische Rotation
[α]/D 75 to 95°, c = 1 in methanol
Kosmetik-Inhaltsstoffe Funktionen
BLEACHING
InChI
InChI=1S/C24H32O7/c1-13-9-14-10-16(26-3)20(28-5)22(30-7)18(14)19-15(12-24(13,2)25)11-17(27-4)21(29-6)23(19)31-8/h10-11,13,25H,9,12H2,1-8H3
InChIKey
YEFOAORQXAOVJQ-UHFFFAOYSA-N
SMILES
O(C1C(=C(OC)C=C2CC(O)(C)C(C)CC3C=C(OC)C(OC)=C(OC)C=3C=12)OC)C
LogP
3.153 (est)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher Xn,N
R-Sätze: 22-50/53
S-Sätze: 60-61
RIDADR  UN 3077 9 / PGIII
WGK Germany  3
HS Code  29093090
Bildanzeige (GHS) GHS hazard pictogramsGHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitsschädlich bei Verschlucken. Akute Toxizität oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H400 Sehr giftig für Wasserorganismen. Kurzfristig (akut) gewässergefährdend Kategorie 1 Warnung GHS hazard pictogramssrc="/GHS09.jpg" width="20" height="20" /> P273, P391, P501
Sicherheit
P273 Freisetzung in die Umwelt vermeiden.

Schisandrin Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Schizandrin is a dibenzocyclooctadiene lignan and a major component of S. chinensis and has diverse biological activities. It induces cell cycle arrest at the G0/G1 phase and inhibits growth of T47D and MDA-MB-231 breast cancer cells when used at a concentration of 100 μM. Schizandrin (10 and 100 μM) prevents glutamate-induced cytotoxicity, inhibits production of nitric oxide (NO) and reactive oxygen species (ROS), and preserves the mitochondrial membrane potential in isolated rat cortical cells. It reduces apoptosis induced by cisplatin in HK-2 human kidney cells. In vivo, schizandrin (1 and 10 mg/kg, p.o.) reverses scopolamine-induced impairment of spatial memory and the passive avoidance response in rats. It enhances oxotremorine-induced tremors in mice. Schizandrin (10 mg/kg) reduces serum levels of IgE, IgG1, IL-4, and IFN-γ in an ovalbumin-sensitized mouse model of allergy.

Verwenden

Schizandrin may be used in oxidative stress-related cell signaling studies.

Application

Schizandrin is a natural compound that belongs to the group of schisandrins. Schizandrins are a class of compounds with biochemical properties and biological activities, such as anti-inflammatory, antioxidant, and anti-cancer effects. This compound has been shown to have pro-apoptotic properties in a model system. It has also demonstrated the ability to inhibit influenza A virus replication in vitro and protect mice against Listeria monocytogenes infection. It can be used as an inhibitor of gsh-px activity in myocardial infarcts.

Biochem/physiol Actions

Schizandrin is a natural product with several biological properties involved with antioxidant and anti-inflammatory activities. It reduces the formation of ROS, inhibits the mitochondrial pathway of the apoptotic process and oxidative stress. Schizandrin has been reported to have hepatoprotective, antitumor, antiviral, and antiamnesic effects, and has neuroprotective activity against glutamate induced neurotoxicity.

Schisandrin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Schisandrin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 373)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Chengdu Biopurify Phytochemicals Ltd.
+86-28-82633860; +8618080483897
sales@biopurify.com China 3751 58
Wuhan JiyunZen Tech Co., Ltd.
+86-18062099985
Amyjiyunzen@yeah.net China 672 58
Lianyungang Kaiyu Environmental Tech Co., Ltd.
+86-0086-19851820538 +8619851820538
carlos@khonorchem.com China 314 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21610 55
Guangzhou PI PI BIOTECH INC
+86-86-020-81716320 +8613602409664
Sales@pipitech.com China 973 55
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3619 58
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29843 58
Chengdu GLP biotechnology Co Ltd
028-87075086 13350802083
scglp@glp-china.com CHINA 1824 58
Hubei Jusheng Technology Co.,Ltd.
18871490254
linda@hubeijusheng.com CHINA 28172 58
Xi'an Kono chem co., Ltd.,
029-86107037 13289246953
info@konochemical.com China 1169 58

7432-28-2()Verwandte Suche:


  • SCHIZANDROL
  • Schisandrin,Schizandrin
  • chisandrin 5,6,7,8-Tetrahydro-6,7-dimethyl-1,2 3,10,11,12-hexamethoxydibenzo[a,c]cycloocten-6-ol
  • Schizandrin, >=98%
  • Schizandrin, 98%, from Schisandra chinensis (Turcz.) Baill.
  • Schisandrae Berry Extract
  • Schisandrol A 7432-28-2
  • SCHIZANDROL A
  • SCHIZANDRIN
  • SCHISANDRIN
  • SCHISANDROL A
  • WUWEIZI ALCOHOL A
  • SCHISANDRIN (SCHISANDROL A)
  • Schizandrin std.
  • Schisandrin(Schizandrol A)
  • Schisadrol A
  • dibenzo(a,c)cycloocten-6-ol,5,6,7,8-tetrahydro-6,7-dimethyl-1,23,10,11,12-hex
  • schizandra
  • 5,6,7,8-Tetrahydro-6,7-dimethyl-1,2 3,10,11,12-hexamethoxydibenzo[a,c]cycloocten-6-ol
  • (+)-Schizandrin Schisandrin Schisandrine Wuweizi alcohol A Schizandrin
  • 1,2,3,10,11,12-hexamethoxy-6,7-dimethyl-,(6S,7S
  • 12aR)-
  • Dibenzo[a,c]cycloocten-6-ol, 5,6,7,8-tetrahydro-
  • Schisandrol
  • 5,6,7,8-Tetrahydro-1,2,3,10,11,12-hexamethoxy-6,7-dimethyldibenzo[a,c]cycloocten-6-ol
  • Schisandrin (Schizandrol
  • Dibenzo[a,c]cycloocten-6-ol, 5,6,7,8-tetrahydro-1,2,3,10,11,12-hexamethoxy-6,7-dimethyl-, (6S,7S,12aR)-
  • hot selling Schisandra Berries P.E
  • DeoxyschizandrinSchisandra chinensis extract
  • (6S,7S,12aR)-1,2,3,10,11,12-Hexamethoxy-6,7-dimethyl-5,6,7,8-tetrahydrodibenzo[a,c][8]annulen-6-ol
  • Schisandrin methyl
  • Schisandrol A structure
  • Abametapir Impurity 29
  • Schisandrin, 10 mM in DMSO
  • Schisandrinum
  • Extractum Schisandrae chinensis
  • Schisandra schisandrins
  • 7432-28-2
  • C24H32O7
  • Inhibitors
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
  • Miscellaneous Natural Products
  • Natural Plant Extract
  • chemical reagent
  • pharmaceutical intermediate
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