6-Chlor-2,3,4,5-tetrahydro-7,8-dihydroxy-1-(p-hydroxyphenyl)-1H-3-benzazepiniummethansulfonat
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- CAS-Nr.
- 67227-57-0
- Bezeichnung:
- 6-Chlor-2,3,4,5-tetrahydro-7,8-dihydroxy-1-(p-hydroxyphenyl)-1H-3-benzazepiniummethansulfonat
- Englisch Name:
- Fenoldopam mesylate
- Synonyma:
- SKF R-82526;9CL-CORLOPAM;(R)-SKF-82526;(S)-SKF-82526;CORLOPAM MESYLATE;SKF-82526 mesylate;Fenodopam mesylate;FENOLDOPAM MESYLATE;FENOLDIPAM MESYLATE;FENOLDOPAM METHANESULFONATE
- CBNumber:
- CB3729841
- Summenformel:
- C17H20ClNO6S
- Molgewicht:
- 401.86
- MOL-Datei:
- 67227-57-0.mol
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6-Chlor-2,3,4,5-tetrahydro-7,8-dihydroxy-1-(p-hydroxyphenyl)-1H-3-benzazepiniummethansulfonat Eigenschaften
- Schmelzpunkt:
- 274° (dec)
- storage temp.
- room temp
- Löslichkeit
- DMSO: ≥15mg/mL at ~60°C
- Aggregatzustand
- powder
- Farbe
- white to tan
- InChI
- InChI=1S/C17H18ClNO5S/c1-25(22,23)24-17-15(21)8-13-12(16(17)18)6-7-19-9-14(13)10-2-4-11(20)5-3-10/h2-5,8,14,19-21H,6-7,9H2,1H3
- InChIKey
- WOFIIEUMIDZJEJ-UHFFFAOYSA-N
- SMILES
- C12C(=C(Cl)C(OS(C)(=O)=O)=C(O)C=1)CCNCC2C1=CC=C(O)C=C1
- CAS Datenbank
- 67227-57-0(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitsschädlich bei Verschlucken. |
Akute Toxizität oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H317 |
Kann allergische Hautreaktionen verursachen. |
Sensibilisierung der Haut |
Kategorie 1A |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P261, P272, P280, P302+P352,P333+P313, P321, P363, P501 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
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| Sicherheit |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen. |
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6-Chlor-2,3,4,5-tetrahydro-7,8-dihydroxy-1-(p-hydroxyphenyl)-1H-3-benzazepiniummethansulfonat Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Fenoldopam, first approved in the Netherlands in 1992, ended by
reaching its first market, the US, for the short-term management of severe
hypertension, including malignant hypertension, in the hospital setting.
Fenoldopam can be prepared in 3 steps from the corresponding phenethylamine
and aryloxiran, the pivotal step being the cyclisation in benzazepine in acidic
medium. Fenoldopam is a potent dopamine D1 receptor agonist acting
peripherally to produce systemic vasodilation.As it does not cross the bloodbrain
barrier, it does not exert significant central dopaminergic activity.
Fenoldopam also interacts significantly with 5HT1c and 5HT2 receptors. In
comparative trials with the most common drug used for this condition in Europe,
Fenoldopam was found to be appreciably more potent than nifedipine.
Furthermore, Fenoldopam is fast acting and maintains a long-lasting
antihypertensive effect.
Chemische Eigenschaften
White to Off-White Solid
Verwenden
Fenoldopam mesylate may be used to study dopamine D
1-mediated cell signaling.
6-Chlor-2,3,4,5-tetrahydro-7,8-dihydroxy-1-(p-hydroxyphenyl)-1H-3-benzazepiniummethansulfonat Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
6-Chlor-2,3,4,5-tetrahydro-7,8-dihydroxy-1-(p-hydroxyphenyl)-1H-3-benzazepiniummethansulfonat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 157)Lieferanten
67227-57-0(6-Chlor-2,3,4,5-tetrahydro-7,8-dihydroxy-1-(p-hydroxyphenyl)-1H-3-benzazepiniummethansulfonat)Verwandte Suche:
- FENOLDOPAM METHANESULFONATE;CORLOPAM MESYLATE;SKF-82526 MESYLATE
- SKF-82526 mesylate
- 6-CHLORO-2,3,4,5-TETRAHYDRO-1-(4-HYDROXYPHENYL)-1H-3-BENZAZEPINE-7,8-DIOL MESYLATE
- CORLOPAM MESYLATE
- FENOLDOPAM MESYLATE
- 6-chloro-2,3,4,5-tetrahydro-7,8-dihydroxy-1-(p-hydroxyphenyl)-1H-3-benzazepinium methanesulphonate
- Fenodopam mesylate
- FENOLDOPAM METHANESULFONATE
- FenoldopamMesylateC16H16C1N03.CH403S
- (1R)-6-Chloro-2,3,4,5-tetrahydro-1β-(4-hydroxyphenyl)-1H-3-benzazepine-7,8-diol
- (R)-SKF-82526
- SKF R-82526
- (S)-SKF-82526
- 8-Chloro-2-(4-hydroxyphenyl)-4-azabicyclo[5.4.0]undeca-7,9,11-triene-9,10-diol methanesulphonate
- 6-CHLORO-2,3,4,5-TETRAHYDRO-1-(4-HYDROXYPHENYL)-1H-3-BENZAZEPINE-7,8-DIOL
- 9CL-CORLOPAM
- Fenoldopam Mesylate (200 mg)
- FENOLDIPAM MESYLATE
- 8-Chloro-2-(4-hydroxyphenyl)-4-azabicyclo[5.4.0]undeca-7,9,11-triene-9,10-diol methanesulphonate###Unii-inu8H2kawg
- SKF 82526 (mesylate)， Fenoldopam methanesulfonate， Corlopam mesylate
- Fenoldopam mesyalte (SKF82526)
- Fenoldopam Mesylate (1269458)
- 6-Chloro-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol methanesulfonate
- Fenoldopam mesylate, 10 mM in DMSO
- Fenoldopam mesylate【SML0198】
- 67227-57-0
- 67227-57-3
- C16H16ClNO3CH4O3S
- C17H20ClNO6S
- CH4O3SC16H16ClNO3
- Enzyme Inhibitors
- Enzymes, Inhibitors, and Substrates
- Enzyme Inhibitors by Enzyme
- BioChemical
- Biochemicals and Reagents
- Angiotensin Converting Enzyme
- A to C
- CORLOPAM
- Aromatics
- Heterocycles
- Intermediates & Fine Chemicals
- Pharmaceuticals
