Chinese english Germany Japanese Korea

(S)-4-Ethyl-4-hydroxy-7,8-dihydro-1h-pyrano[3,4-f]indolizine-3,6,10(4h)-trione

(S)-4-Ethyl-4-hydroxy-7,8-dihydro-1h-pyrano[3,4-f]indolizine-3,6,10(4h)-trione Struktur
110351-94-5
CAS-Nr.
110351-94-5
Englisch Name:
(S)-4-Ethyl-4-hydroxy-7,8-dihydro-1h-pyrano[3,4-f]indolizine-3,6,10(4h)-trione
Synonyma:
(S)-4-ETHYL-4-HYDROXY-7,8-DIHYDRO-1H-PYRANO[3,4-F]INDOLIZINE-3,6,10(4H)-TRIONE;(4S)-4-Ethyl-4-hydroxy-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,6,10-trione;(S)-trione;(S)-4-hydroxy-4-propyl-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione;RUBI-006;10(4H)-TRIONE;4-F]INDOLIZINE-3;Trihydroxy lactone;Exatecan Impurity 3;8-DIHYDRO-1H-PYRANO[3
CBNumber:
CB41009288
Summenformel:
C13H13NO5
Molgewicht:
263.25
MOL-Datei:
110351-94-5.mol
Request For Quotation

(S)-4-Ethyl-4-hydroxy-7,8-dihydro-1h-pyrano[3,4-f]indolizine-3,6,10(4h)-trione Eigenschaften

Schmelzpunkt:
183-185℃ (decomposition)
Siedepunkt:
666.6±55.0 °C(Predicted)
Dichte
1.50±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
pka
11.20±0.20(Predicted)
Aggregatzustand
Solid
Farbe
Off-white to light brown
InChI
InChI=1S/C13H13NO5/c1-2-13(18)8-5-9-10(15)3-4-14(9)11(16)7(8)6-19-12(13)17/h5,18H,2-4,6H2,1H3/t13-/m0/s1
InChIKey
IGKWOGMVAOYVSJ-ZDUSSCGKSA-N
SMILES
C1(=O)C2N(C(=O)C3COC(=O)[C@@](CC)(O)C=3C=2)CC1
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
HazardClass  IRRITANT
Bildanzeige (GHS) Exclamation Mark (GHS07)
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitsschädlich bei Verschlucken. Akute Toxizität oral Kategorie 4 Warnung P264, P270, P301+P312, P330, P501
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung P264, P280, P305+P351+P338,P337+P313P
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P301+P312 BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.
P330 Mund ausspülen.
P501 Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

(S)-4-Ethyl-4-hydroxy-7,8-dihydro-1h-pyrano[3,4-f]indolizine-3,6,10(4h)-trione Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften

Light yellow solid.

Verwenden

(4S)-4-Ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione is a key intermediate in the synthesis of Irinotecan (I767500) and Camptothecin (C175150) analogs.

synthetische

Synthesis of (S)-4-Ethyl-4-hydroxy-7,8-dihydro-1h-pyrano[3,4-f]indolizine-3,6,10(4h)-trione: Compound (Formula 4) 4.3 g (100 mmol), 200 ml of dichloromethane, 200 ml of 2M sulfuric acid, stirred at room temperature for 2 h, separated the organic layer, washed with saturated brine, dried, recovered dichloromethane to dryness, and recrystallized from isopropanol to obtain S-tricyclic lactone (Formula 1) 1.5 g, mp 172-174°C, [α]D15+115.6° (C=0.5, chloroform), yield 57%.
Synthesis of (S)-4-Ethyl-4-hydroxy-7,8-dihydro-1h-pyrano[3,4-f]indolizine-3,6,10(4h)-trione

target

Camptothecins

Clinical claims and research

Camptothecin is a pentacyclic alkaloid extracted from Camptotheca by Wall et al. in the early 1960s. As an anticancer chemical, the compound has quickly attracted people's attention due to its strong inhibitory activity against leukemia and various other malignant tumors in animal experiments. In the total synthesis of camptothecin, The total synthesis of (S)-4-Ethyl-4-hydroxy-7,8-dihydro-1h-pyrano[3,4-f]indolizine-3,6,10(4h)-trione is research focus.

(S)-4-Ethyl-4-hydroxy-7,8-dihydro-1h-pyrano[3,4-f]indolizine-3,6,10(4h)-trione Upstream-Materialien And Downstream Produkte

Upstream-Materialien

(S)-4-Ethyl-4,6-dihydroxy-3,10-dioxo-3,4,8,10-tetrahydro-1H-pyrano[3,4-f]indolizine-7-carboxylic acid tert-butyl ester CHUGAI-01 (4'S)-4'-ethyl-1',4',7',8'-tetrahydro-4'-hydroxy-3'H,10'H-spiro[1,3-dioxolane-2,6'-pyrano[3,4-f]indolizine]-3',10'-dione

Downstream Produkte

(S)-4-Ethyl-4-hydroxy-7,8-dihydro-1h-pyrano[3,4-f]indolizine-3,6,10(4h)-trione Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 245)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Chemyouth Life Science（Suzhou）Co.,Ltd 18605123100
 kaiyuezhang@chemyouth.com China 153 58
WuYan Pharmaceutical Technology (Shanghai) Co., Ltd. 18621565901
 sales@wuyanpharm.com China 139 55
Shanghai Tekanbio Pharm-Tech Co., Ltd. 021-50896099 18017206244
 sales@tekanbio.com China 88 58
NOTA Chemical (Shanghai) Co.,Ltd 021-50189163
sales@notachem.com China 208 64
Chengdu Zen Sunda Bio-pharmaceutical Technology Co., Ltd. 19981275275
 sales@zsdpharm.com China 388 58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 025-66028182 17714375163
 yftan@aikonchem.com China 16674 50
Accela ChemBio Co.,Ltd. 021-50795510 4000665055
 marketing@accelachem.com China 10972 64
Z IntellecChem & Tech. Co., Ltd 13179383568; 15050866711
 contact@zintellec.com China 317 58
Sichuan Yuehe Bio-Pharmaceutical Co.,Ltd 028-82729560 17365561851
 tangzhichen@yuehepharm.com China 215 58
Zhejiang Boxiao Bio-Pharmaceutical Co., Ltd. +86-571-63280982
Helena_Huang@bx-biopharm.com China 47 58

110351-94-5()Verwandte Suche:

Benzol Trifluoressigsäure Acetylen Borsure
  • 1H-Pyrano[3,4-f]indolizine-3,6,10(4H)-trione, 4-ethyl-7,8-dihydro-4-hydroxy-, (S)-
  • RUBI-006
  • (s)-8-Ethyl-8-hydroxy-2,3,5,8-tetrahydro-6-oxa-3a-aza-cyclopenta[b]naphthalene-1,4,7-trione
  • (S)-4-hydroxy-4-propyl-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione
  • (S)-4-hydroxy-4-propyl-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3
  • (S)-4-Ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione
  • 1H-Pyrano[3,4-f]indolizine-3,6,10(4H)-trione, 4-ethyl-7,8-dihydro-4-hydroxy-, (4S)-
  • (S)-4-ETHYL-4-HYDROXY-7,8-DIHYDRO-1H-PYRANO[3,4-F]INDOLIZINE-3,6,10(4H)-TRIONE 110351-94-5
  • (S)-4-ETHYL-4-HYDROXY-7
  • 10(4H)-TRIONE
  • 4-F]INDOLIZINE-3
  • 8-DIHYDRO-1H-PYRANO[3
  • Exatecan intermediates
  • Trihydroxy lactone
  • Exatecan Intermediate 1
  • Exatecan Impurity 3
  • (S)-4-Ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolidin-3,6,10(4H)-trione
  • (S) 4-ethyl-4-hydroxy-7,8-dihydro-1H-pyrano O [3,4-F] indoleazine-3,6,10 (4) - one
  • (4S)-4-Ethyl-4-hydroxy-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,6,10(4H)trione
  • Irinotecan Impurity 64
  • (S)-8-Ethyl-8-hydroxy-2,3,5,8-tetrahydro- 6-oxa-3-aza-cyclopenta [beta] naphthalene-1,4,7-trione
  • (4S)-4-Ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione
  • (4S)-4-Ethyl-4-hydroxy-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,6,10-trione
  • (S)-4-ETHYL-4-HYDROXY-7,8-DIHYDRO-1H-PYRANO[3,4-F]INDOLIZINE-3,6,10(4H)-TRIONE
  • (S)-trione
  • Irinotecan Intermediates (94-5)
  • 110351-94-5
  • Anti-cancer
  • ADCs Linkers
  • 1
Copyright 2019 © ChemicalBook. All rights reserved