Fexinidazole

59729-37-2

CAS-Nr.: 59729-37-2

Englisch Name:: Fexinidazole

Synonyma:: HOE-239;Fexinidazole;HOE-239;HOE239;HOE 239;Fexinidazole (HOE 239);Fexinidazole, 10 mM in DMSO;1-Methyl-2-[[4-(methylthio)phenoxy]methyl]-5-nitro-1H-imidazole;1H-Imidazole, 1-methyl-2-[[4-(methylthio)phenoxy]methyl]-5-nitro-;antitrypanosomal,nitroimidazole,sleeping,HOE239,Fexinidazole,T.brucei,sickness,orally,HOE-239,Inhibitor,inhibit,HAT,Parasite

CBNumber:: CB41178746

Summenformel:: C12H13N3O3S

Molgewicht:: 279.31

MOL-Datei:: 59729-37-2.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 100

Fexinidazole Eigenschaften

Siedepunkt:: 501 °C

Dichte: 1.33±0.1 g/cm3(Predicted)

storage temp.: Sealed in dry,Room Temperature

Löslichkeit: DMF: 20 mg/mL; DMF:PBS (pH 7.2) (1:8): 0.11 mg/mL; DMSO: 10 mg/mL; Ethanol: 0.2 mg/mL

Aggregatzustand: A crystalline solid

pka: 1.82±0.25(Predicted)

Farbe: Light yellow to yellow

Sicherheit

Fexinidazole Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Fexinidazole is a medication used in the treatment of African trypanosomiasis caused by trypanosoma brucei gambiense. An antitrypanosomal agent. It also functions as a medication used against the main species that cause visceral and cutaneous new World leishmaniasis.

Synthese

The synthesis of Fexinidazole started with the methylation of nitroimidazole (2.1) using dimethyl sulphate in dioxane to give intermediate 2.2 in 82% yield. The methylated imidazole 2.2 was subsequently reacted with formaldehyde in dimethyl sulfoxide to produce the corresponding imidazolyl methanol derivative 2.3 in 62% yield. Intermediate 2.3 was reacted with dichlorosulfoxide in chloroform to give the corresponding 2-chloromethyl-1-methyl-5-nitroimidazole 2.4, which was then coupled with 4-methylmercaptophenol (2.5) in the presence of acetone and potassium carbonate to produce "wet" fexinidazole hydrochloride (2.6). The final free base of fexinidazole (2) was obtained by neutralisation with 25% aqueous ammonia solution, giving an overall yield of 65% for the entire three-step reaction.
Synthesis of Fexinidazole

Fexinidazole Upstream-Materialien And Downstream Produkte

Upstream-Materialien

4-(Methylthio)phenol 1H-Imidazole-2-methanol, 1-methyl-5-nitro-, 2-methanesulfonate 2-(chloroMethyl)-1-Methyl-5-nitro-1H-iMidazole Caesiumcarbonat Acetonitril Kaliumiodid

Downstream Produkte

Fexinidazole Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 100)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Hebei Chuanghai Biotechnology Co,.LTD	+86-13131129325	sales1@chuanghaibio.com	China	5251	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29734	60
Shandong chuangyingchemical Co., Ltd.	18853181302	sale@chuangyingchem.com	CHINA	5906	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19552	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-87569266 +86-17392581500	1015@dideu.com	China	3965	58
Zhengzhou Alfa Chemical Co.,Ltd	+8618530059196	sale04@alfachem.cn	China	12071	58
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32434	58
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30229	58
Wuhan Demeikai Biotechnology Co., Ltd	+8618942921723	info@dmksw.xin	China	717	58

59729-37-2()Verwandte Suche:

Tinidazol 1-Methyl-5-nitro-1H-imidazol-2-methanol

1-Methyl-2-[[4-(methylthio)phenoxy]methyl]-5-nitro-1H-imidazole
HOE-239
Fexinidazole
Fexinidazole (HOE 239)
HOE-239;HOE239;HOE 239
antitrypanosomal,nitroimidazole,sleeping,HOE239,Fexinidazole,T.brucei,sickness,orally,HOE-239,Inhibitor,inhibit,HAT,Parasite
1H-Imidazole, 1-methyl-2-[[4-(methylthio)phenoxy]methyl]-5-nitro-
Fexinidazole, 10 mM in DMSO
59729-37-2
Inhibitors
apis