Resmetirom

920509-32-6

CAS-Nr.: 920509-32-6

Englisch Name:: Resmetirom

Synonyma:: Resmetirom;CS-2429;VIA3196;MGL-3196;VIA-3196;Resmetirom(MGL-3196);MGL-3196(Resmetirom);Resmetirom, 10 mM in DMSO;Resmetirom (MGL-3196,VIA-3196);MGL-3196; MGL 3196; MGL3196; VIA-3196; VIA3196; VIA-3196

CBNumber:: CB42714673

Summenformel:: C17H12Cl2N6O4

Molgewicht:: 435.22

MOL-Datei:: 920509-32-6.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 253

Resmetirom Eigenschaften

Dichte: 1.65±0.1 g/cm3(Predicted)

storage temp.: Inert atmosphere,Store in freezer, under -20°C

Löslichkeit: DMSO:59.0(Max Conc. mg/mL);135.56(Max Conc. mM)

Aggregatzustand: A crystalline solid

pka: 3.96±0.40(Predicted)

Farbe: Yellow to orange

InChI: InChI=1S/C17H12Cl2N6O4/c1-7(2)9-5-13(22-23-15(9)26)29-14-10(18)3-8(4-11(14)19)25-17(28)21-16(27)12(6-20)24-25/h3-5,7H,1-2H3,(H,23,26)(H,21,27,28)

InChIKey: FDBYIYFVSAHJLY-UHFFFAOYSA-N

SMILES: N1=C(C#N)C(=O)NC(=O)N1C1=CC(Cl)=C(OC2=NNC(=O)C(C(C)C)=C2)C(Cl)=C1

Sicherheit

Risiko- und Sicherheitserklärung
Gefahreninformationscode (GHS)

Bildanzeige (GHS)

Alarmwort

Warnung

Gefahrenhinweise

Code	Gefahrenhinweise	Gefahrenklasse	Abteilung	Alarmwort	Symbol	P-Code
H302	Gesundheitsschädlich bei Verschlucken.	Akute Toxizität oral	Kategorie 4	Warnung	src="/GHS07.jpg" width="20" height="20" />	P264, P270, P301+P312, P330, P501
H315	Verursacht Hautreizungen.	Hautreizung	Kategorie 2	Warnung	src="/GHS07.jpg" width="20" height="20" />	P264, P280, P302+P352, P321,P332+P313, P362
H319	Verursacht schwere Augenreizung.	Schwere Augenreizung	Kategorie 2	Warnung	src="/GHS07.jpg" width="20" height="20" />	P264, P280, P305+P351+P338,P337+P313P
H335	Kann die Atemwege reizen.	Spezifische Zielorgan-Toxizität (einmalige Exposition)	Kategorie 3 (Atemwegsreizung)	Warnung	src="/GHS07.jpg" width="20" height="20" />

Sicherheit

P261	Einatmen von Staub vermeiden.
P305+P351+P338	BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

Resmetirom Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

MGL-3196 is an agonist of thyroid hormone receptor β (TRβ; EC₅₀s = 0.21 and 3.74 μM for TRβ and TRα, respectively). It also inhibits ether-a-go-go-related gene (ERG) potassium channels (IC₅₀ = 30 μM). MGL-3196 is a liver-directed compound, with a liver to plasma ratio of 8:1 in mice with diet-induced obesity (DIO), which reduces the likelihood of adverse effects from systemic exposure. It does not affect the expression of α-myosin heavy chain (α-MHC) in a rat model of hypothyroidism, an effect mediated by TRα, indicating low potential for cardiac adverse effects. MGL-3196 lowers non-HDL cholesterol and liver triglycerides without affecting thyroid stimulating hormone (Tsh) levels in rat and rabbit models of hypercholesterolemia. It also lowers plasma glucose levels and improves insulin sensitivity in DIO mice. Formulations containing MGL-3196 are in clinical trials for the treatment of non-alcoholic steatohepatitis (NASH) and familial hypercholesterolemia.

Verwenden

Resmetirom (MGL-3196) is a liver-directed, orally active, selective thyroid hormone receptor-beta agonist. It works by blocking the formation of fat in the liver and can be used to treat non-alcoholic steatohepatitis (NASH).

Indications

Resmetirom is an oral thyroid hormone receptor-β (THR-β) agonist being developed by Madrigal Pharmaceuticals, Inc. to target the key underlying causes of metabolic dysfunction associated steatohepatitis (MASH) [previously known as nonalcoholic steatohepatitis (NASH)]. In March 2024, resmetirom was approved for use (under accelerated approval) in conjunction with diet and exercise for the treatment of adults with noncirrhotic NASH with moderate to advanced liver fibrosis (consistent with stages F2 to F3 fibrosis) in the USA. Currently, Resmetirom has been approved by the FDA for the treatment of adult patients with non-alcoholic steatohepatitis (NASH).

Resmetirom Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Resmetirom Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 253)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Shanghai jinsheng pharma tech co.,ltd	13585563093	pinpinzheng@jspharmatech.com	China	374	58
Zhejiang Hengkang Pharmaceutical Co.Ltd.	+8615168202657	commercial@hengkangpharm.cn	China	42	58
Chongqing jooe co., ltd	+86-19923400328 +86-15223382610	info@jooe.com	China	5617	58
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.	+86-18600796368	sales@sjar-tech.com	China	504	58
Hebei Junhua Import and Export Co., LTD	+85259680964	junhua1@hb-junhua.com	China	933	58
Wuhan JiyunZen Tech Co., Ltd.	+86-18062099985	Amyjiyunzen@yeah.net	China	663	58
Capot Chemical Co.,Ltd.	+8613336195806	sales@capot.com	China	29734	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	8497	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58

Resmetirom (MGL-3196,VIA-3196)
MGL-3196; MGL 3196; MGL3196; VIA-3196; VIA3196; VIA-3196
VIA3196
VIA-3196
MGL-3196
Resmetirom
2-[3,5-Dichloro-4-[[1,6-dihydro-5-(1-methylethyl)-6-oxo-3-pyridazinyl]oxy]phenyl]-2,3,4,5-tetrahydro-3,5-dioxo-1,2,4-triazine-6-carbonitrile
CS-2429
1,2,4-Triazine-6-carbonitrile, 2-[3,5-dichloro-4-[[1,6-dihydro-5-(1-methylethyl)-6-oxo-3-pyridazinyl]oxy]phenyl]-2,3,4,5-tetrahydro-3,5-dioxo-
2-(3,5-dichloro-4-((5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yl)oxy)phenyl)-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile
Resmetirom(MGL-3196)
MGL-3196(Resmetirom)
Resmetirom, 10 mM in DMSO
920509-32-6
C17H12Cl2N6O4
API