Nedaplatin
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- CAS-Nr.
- 95734-82-0
- Englisch Name:
- Nedaplatin
- Synonyma:
- 254-s;Aqupla;Nedaplait;NEDAPLATIN;NSC 375101D;Nedaplatin, >=99%;Nedaplatin USP/EP/BP;Nedaplatin (NSC 375101D);cis-diammine(glycolato)platinum(ii);(glycolato-o,o')diammineplatinum(ii)
- CBNumber:
- CB5127746
- Summenformel:
- C2H6N2O3Pt
- Molgewicht:
- 301.17
- MOL-Datei:
- 95734-82-0.mol
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Nedaplatin Eigenschaften
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- Löslichkeit
- H2O : 13.6 mg/mL (44.86 mM; Need ultrasonic and warming; DMSO can inactivate Nedaplatin's activity)DMF : < 1 mg/mL (insoluble; DMSO can inactivate Nedaplatin's activity)
- Aggregatzustand
- Powder
- Farbe
- Light yellow to yellow
- InChI
- InChI=1S/C2H3O3.2H2N.Pt/c3-1-2(4)5;;;/h1H2,(H,4,5);2*1H2;/q3*-1;+4/p-1
- InChIKey
- GRHLMSBCOPRFNA-UHFFFAOYSA-M
- SMILES
- N[Pt+2]1([O-]CC(=O)[O-]1)N
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| WGK Germany |
WGK 3 |
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| Speicherklasse |
6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials |
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| Hazard Classifications |
Acute Tox. 2 Oral
Carc. 1B
Eye Irrit. 2
Resp. Sens. 1B
Skin Irrit. 2
Skin Sens. 1B
STOT SE 3 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitsschädlich bei Verschlucken. |
Akute Toxizität oral |
Kategorie 4 |
Warnung |
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P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen. |
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Nedaplatin Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Nedaplatin, a novel second generation platinum complex, was marketed
in Japan for the treatment of a variety of cancers including: head and neck, small-cell
and non-small cell lung, oesophageal, prostatic, testicular, ovarian, cervical, bladder,
and uterine cancers. Platinum anticancer agents, prototyped by cisplatin, have been
reported to be hydrolyzed to the mono- or diaquated species of diamine platinum which
react with nucleophilic sites on DNA to cause intrastrand and interstrand crosslinks and
DNA-protein crosslinks, which result in cytotoxicity. Nedaplatin was reportedly more
active than cisplatin against several solid tumors while sharing less nephro- and
gastrointestinal toxicity to cisplatin in viva The minimal renal toxicity displayed by
nedaplatin allows its use in patients with deteriorated renal function.
Verwenden
Nedaplatin is a platinum complex that has potent antineoplatic activity.
Pharmazeutische Anwendungen
Nedaplatin, cis-diammineglycolatoplatinum(II), is structurally similar to carboplatin.
The chemical structure consists of a central platinum(II) atom with two cis-ammonia groups as nonleaving
groups and – in contrast to carboplatin – the dianionic form of glycolic acid as the leaving group. Nedaplatin
has been approved for the clinical use in the Japanese market for the treatment of head and neck, testicular,
ovarian, lung and cervical cancer. It is typically administered by IV injection and its dose-limiting side effect
is myelosuppression.
Nedaplatin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Nedaplatin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 267)Lieferanten
95734-82-0()Verwandte Suche:
- (glycolato-o,o')diammineplatinum(ii)
- cis-diammine(glycolato)platinum(ii)
- NEDAPLATIN
- 254-s
- Aqupla
- cis-diamine-glycolate-O,O'-platinum(II)
- o(sup2))-diammine(hydroxyacetato(2-)-o(sup1(sp-4-3)-platinu
- Nedaplait
- o(sup 2))- diammine(hydroxyacetato(2-)-o(sup 1 (sp-4-3)-platinu (glycolato-o,o')diammineplatinum(ii) 254-s cis-diammine(glycolato)platinum(ii) nedaplatin nsc 375101d
- 2,2-diaMino-1,3-dioxa-2-platinacyclopentan-4-one
- PlatinuM,diaMMine[(hydroxy-kO)acetato(2-)-kO]-, (SP-4-3)-
- (SP-4-3)-diammine[2-(hydroxy-κO)acetato(2-)-κO]-platinum
- Nedaplatin, >=99%
- cis-Diammine(glycolato(2-)O,O')platinum
- Cis-diammine-glycoloato-O,O'-platinum(II)
- platinum(2+) azanide- hydroxyacetic acid(1:2:1)
- NSC 375101D
- Nedaplatin USP/EP/BP
- Nedaplatin (NSC 375101D)
- 95734-82-0
- C2H4N2O3Pt
- C2H8N2O3Pt
- C2H2O3Pt2H3N
- C2H6N2O3Pt
- Inhibitors
- Anticancer
- Anticancer Platinum Agent
