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Dolutegravir Impurity 3

1973402-05-9

CAS-Nr.: 1973402-05-9

Englisch Name:: Dolutegravir Impurity 3

Synonyma:: Dotiravir Impurity 3;Dolutegravir Impurity 3;Dolutegravir impurity A;Dolutegravir Impurity 51;DolutegravirImpurity9SodiumSalt;Dolutegravir Ring Open Impurity;(R)-N-(2,4-difluorobenzyl)-9-hydroxy-2-(4-hydroxybutan-2-yl)-1,8-dioxo-2,8-dihydro-1H-pyrido[1,2-a]p;(R)-N-(2,4-difluorobenzyl)-9-hydroxy-2-(4-hydroxybutan-2-yl)-1,8-dioxo-1,8-dihydro-2H-pyrido[1,2-a]pyrazine-7-carboxamide;N-[(2,4-Difluorophenyl)methyl]-1,8-dihydro-9-hydroxy-2-[(1R)-3-hydroxy-1-methylpropyl]-1,8-dioxo-2H-pyrido[1,2-a]pyrazine-7-carboxamide;2H-Pyrido[1,2-a]pyrazine-7-carboxamide, N-[(2,4-difluorophenyl)methyl]-1,8-dihydro-9-hydroxy-2-[(1R)-3-hydroxy-1-methylpropyl]-1,8-dioxo-

CBNumber:: CB53154305

Summenformel:: C20H19F2N3O5

Molgewicht:: 419.38

MOL-Datei:: 1973402-05-9.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 36

Dolutegravir Impurity 3 Eigenschaften

Schmelzpunkt:: 95-100°C

Siedepunkt:: 662.3±55.0 °C(Predicted)

Dichte: 1.51±0.1 g/cm3(Predicted)

storage temp.: -20°C Freezer, Under inert atmosphere

Löslichkeit: DMSO (Slightly), Methanol (Slightly)

Aggregatzustand: Solid

pka: 4.50±1.00(Predicted)

Farbe: Yellow

InChIKey: NQVIDZANHVWALI-LLVKDONJSA-N

SMILES: C12=C(O)C(=O)C(C(NCC3=CC=C(F)C=C3F)=O)=CN1C=CN([C@H](C)CCO)C2=O

Sicherheit

Dolutegravir Impurity 3 Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

(R)-N-(2,4-Difluorobenzyl)-9-hydroxy-2-(4-hydroxybutan-2-yl)-1,8-dioxo-2,3,4,8-tetrahydro-1H-pyrido[1,2-a]pyrazine-7-carboxamide is impurity E of Dolutegravir (D528800), which is a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir is currently in Phase III clinical trials for the treatment of HIV infection. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mononuclear cells (PBMCs), MT-4 cells and CIP4 cells infected with a self-inactivating PHIV lentiviral vector.

Dolutegravir Impurity 3 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Dolutegravir Impurity 3 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 36)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14332	58
AFINE CHEMICALS LIMITED	+86-0571-85134551	sales@afinechem.com	China	15126	58
CR Corporation Limited	+8613062833949	fred.wen@crcorporation.cn	China	8647	58
China National Standard Pharmaceutical Corporation Limited	+8615391658522	overseasales@yongstandards.com	China	11922	58
HANGZHOU LEAP CHEM CO., LTD.	+86-571-87711850	market18@leapchem.com	China	43339	58
Moxin Chemicals	+86-17320513646 +8617320513646	anna@molcoo.com	China	10000	58
Pure Research Chemicals	+86-13564847951 +86-18019592524	info@purerechem.com	China	1000	58
Aurisco Pharmaceutical (Tianjin) Inc.	022-59885855		China	96	58
S.Z. PhyStandard Bio-Tech. Co., Ltd.	0755-4000505016 13380397412	3001272453@qq.com	China	5158	50
ChemStrong Scientific Co.,Ltd	0755-0755-66853366 13670046396	sales@chem-strong.com	China	18298	56

Dolutegravir impurity 2/2H-Pyrido[1,2-a]pyrazine-7-carboxamide, N-[(2,4-difluorophenyl)methyl]-1,8-dihydro-9-hydroxy-2-[(1R)-3-hydroxy-1-methylpropyl]-1,8-dioxo-
2H-Pyrido[1,2-a]pyrazine-7-carboxamide, N-[(2,4-difluorophenyl)methyl]-1,8-dihydro-9-hydroxy-2-[(1R)-3-hydroxy-1-methylpropyl]-1,8-dioxo-
Dolutegravir impurity A
Dolutegravir Impurity 3
N-[(2,4-Difluorophenyl)methyl]-1,8-dihydro-9-hydroxy-2-[(1R)-3-hydroxy-1-methylpropyl]-1,8-dioxo-2H-pyrido[1,2-a]pyrazine-7-carboxamide
Dolutegravir Impurity 51
(R)-N-(2,4-difluorobenzyl)-9-hydroxy-2-(4-hydroxybutan-2-yl)-1,8-dioxo-2,8-dihydro-1H-pyrido[1,2-a]p
(R)-N-(2,4-difluorobenzyl)-9-hydroxy-2-(4-hydroxybutan-2-yl)-1,8-dioxo-1,8-dihydro-2H-pyrido[1,2-a]pyrazine-7-carboxamide
DolutegravirImpurity9SodiumSalt
Dotiravir Impurity 3
Dolutegravir Ring Open Impurity
1973402-05-9