Ripretinib
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- CAS-Nr.
- 1442472-39-0
- Englisch Name:
- Ripretinib
- Synonyma:
- KIT/PDGFR INHIBITOR(DCC-2618);Ripretinib (DCC-2618);Ripretinib;DCC-2618 HCl;1442472-39-0;13C6]-Ripretinib;KIT/PDGFR inhibitor;Ripretinib USP/EP/BP;Ripretinib Impurity 3;Oliceridine Impurity 17
- CBNumber:
- CB53365156
- Summenformel:
- C24H21BrFN5O2
- Molgewicht:
- 510.36
- MOL-Datei:
- 1442472-39-0.mol
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Ripretinib Eigenschaften
- Siedepunkt:
- 568.6±50.0 °C(Predicted)
- Dichte
- 1.544±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- Löslichkeit
- DMSO:25.0(Max Conc. mg/mL);49.0(Max Conc. mM)
- Aggregatzustand
- A solid
- pka
- 12.15±0.70(Predicted)
- Farbe
- White to light yellow
- InChIKey
- CEFJVGZHQAGLHS-UHFFFAOYSA-N
- SMILES
- N(C1=CC(C2=CC3=C(N(CC)C2=O)C=C(NC)N=C3)=C(Br)C=C1F)C(NC1=CC=CC=C1)=O
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitsschädlich bei Verschlucken. |
Akute Toxizität oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizität (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen. |
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Ripretinib Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Ripretinib is used in the treatment of gastrointestinal stromal tumors (GISTs).
Trademarks
Qinlock
Synthese
The diethyl ester 297 was reacted with triethyl orthoformate and acetic anhydride by heating. Subsequent addition of aqueous ammonia afforded pyridine 298. Pyridine 298 was treated neat with phosphorus oxychloride at reflux to afford dichloride 299 in 90% yield. The 4-chloro group of pyridine 299 was selectively replaced by ethylamine in cooled acetonitrile to afford the product. Oxidation state adjustment using lithium aluminum hydride followed by MnO2 afforded 4-aminopyridine 300. Starting from acid 301, a three-step reaction process involving nitration, esterification, and reduction provided ester 302 directly. Ester 302 reacted with intermediate 300 in DMA (N,N-dimethylacetamide) with the aid of KF on alumina to form naphthyridinone ring system 303 via Knoevenagel cyclization. Methylamine groups were installed on naphthyridinone ring system 303. Reaction with phenylisocyanate to form urea completed the preparation of ripretinib.
Ripretinib Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Ripretinib Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 130)Lieferanten
- KIT/PDGFR inhibitor(DCC2618)
- KIT/PDGFR INHIBITOR(DCC-2618)
- Ripretinib
- Ripretinib (DCC-2618)
- DCC-2618; DCC 2618; DCC2618; RIPRETINIB;
- DCC-2618;KIT/PDGFR INHIBITOR
- KIT/PDGFR inhibitor
- N-[4-Bromo-5-[1-ethyl-1,2-dihydro-7-(methylamino)-2-oxo-1,6-naphthyridin-3-yl]-2-fluorophenyl]-N'-phenylurea
- Urea, N-[4-bromo-5-[1-ethyl-1,2-dihydro-7-(methylamino)-2-oxo-1,6-naphthyridin-3-yl]-2-fluorophenyl]-N'-phenyl-
- 1-(4-bromo-5-[1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl]-2-fluorophenyl)-3-phenylurea
- Ripretinib USP/EP/BP
- DCC-2618 HCl
- 13C6]-Ripretinib
- Ripretinib Impurity 3
- Oliceridine Impurity 17
- Ripretinib, 10 mM in DMSO
- 1442472-39-0
- 1442472-39-0
- C24H21BrFN5O2
- API
