REVERSINE
|
|
|
- CAS-Nr.
- 656820-32-5
- Englisch Name:
- REVERSINE
- Synonyma:
- CS-870;REVERSINE;Reversine, >96%;Reversine, >=98%;REVERSINE USP/EP/BP;Picropodophyllin (PPP);Reversine, 10 mM in DMSO;2-(4-MORPHOLINOANILINO)-6-CYCLOHEXYLAMINOPURINE;Reversine, Cell-permeable A3 receptor antagonist;N6-CYCLOHEXYL-N2-(4-MORPHOLINOPHENYL)-9H-PURINE-2,6-DIAMINE
- CBNumber:
- CB5470820
- Summenformel:
- C21H27N7O
- Molgewicht:
- 393.49
- MOL-Datei:
- 656820-32-5.mol
|
REVERSINE Eigenschaften
- Schmelzpunkt:
- 305℃ (decomposition)
- Siedepunkt:
- 736.4±70.0 °C(Predicted)
- Dichte
- 1.343±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- Löslichkeit
- DMSO: 7 mg/mL, soluble
- Aggregatzustand
- solid
- pka
- 10.51±0.10(Predicted)
- Farbe
- Off-white
- Stabilität:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Kennzeichnung gefährlicher |
Xn |
|
|
| R-Sätze: |
22 |
|
|
| WGK Germany |
3 |
|
|
| Bildanzeige (GHS) |
|
| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitsschädlich bei Verschlucken. |
Akute Toxizität oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
|
| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P301+P312 |
BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P330 |
Mund ausspülen. |
| P501 |
Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
|
REVERSINE Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
Beschreibung
Reversine is a 2,6-disubstituted purine derivative that was originally found to induce dedifferentiation of C2C12 culture myoblast cells into stem cell progenitors when used at a concentration of 5 μM for four days. Depending on cell type, reversine promotes either differentiation or dedifferentiation. For example, in NT2 neuronal and HL-60 human promyelocytic leukemia cells, it induces differentiation. It inhibits the Aurora A, B, and C kinases with IC
50 values of 98-876 nM and acts as an antagonist at the adenosine A
3 receptor with a K
i value of 0.66 μM. Reversine is also used for studies of chromosome segregation. It inhibits the mitotic spindle checkpoint enzyme MPS1 with IC
50 values of 6 and 2.8 nM for its kinase domain and full-length version, respectively). Reversine induces autophagy in WRO human follicular thyroid cancer cells and decreases Akt/mTOR signaling.
Verwenden
Reversine acts as a potent human A3 adenosine receptor antagonist and pan-aurora A/B/C kinase inhibitor. Used for stem cell differentiation.
Definition
ChEBI: A member of the class of purines that is 9H-purine in which the hydrogens at positions 2 and 6 are replaced by a [4-(morpholin-4-yl)phenyl]nitrilo group and a cyclohexylamino group, respectively.
REVERSINE Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
REVERSINE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 172)Lieferanten
- 9H-Purine-2,6-diamine,N6-cyclohexyl-N2-[4-(4-morpholinyl)phenyl]-
- N6-Cyclohexyl-N2-(4-morpholinophenyl)-7H-purine-2,6-diamine
- 2-(4-MORPHOLINOANILINO)-6-CYCLOHEXYLAMINOPURINE
- N6-CYCLOHEXYL-N2-(4-MORPHOLINOPHENYL)-9H-PURINE-2,6-DIAMINE
- Picropodophyllin (PPP)
- N6-Cyclohexyl-N2-[4-(4-morpholinyl)phenyl]-1H-purine-2,6-diamine Reversine
- Reversine
N6-Cyclohexyl-N2-[4-(4-morpholinyl)phenyl]-1H-purine-2,6-diamine
- REVERSINE
- N6-CYCLOHEXYL-N2-[4-(4-MORPHOLINYL)PHENYL]-1H-PURINE-2,6-DIAMINE
- Reversine, >=98%
- Reversine, >96%
- CS-870
- REVERSINE USP/EP/BP
- Reversine, Cell-permeable A3 receptor antagonist
- Reversine, 10 mM in DMSO
- 656820-32-5
- C21H27N7O
- Inhibitors
