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Pemigatinib

Pemigatinib Struktur
1513857-77-6
CAS-Nr.
1513857-77-6
Englisch Name:
Pemigatinib
Synonyma:
IBI-375;INCB54828;INCB 54828;INCB-54828;INCB-054828;Pemigatinib;2H8]-Pemigatinib;Pemigatinib, 10 mM in DMSO;Terbufos Impurity 14 (Ethion);3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(morpholinomethyl)-3,4-dihydro-1H-pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2(7H)-one
CBNumber:
CB54796678
Summenformel:
C24H27F2N5O4
Molgewicht:
487.5
MOL-Datei:
1513857-77-6.mol
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Pemigatinib Eigenschaften

Siedepunkt:
697.6±55.0 °C(Predicted)
Dichte
1.44±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
Löslichkeit
DMSO:40.0(Max Conc. mg/mL);82.05(Max Conc. mM)
Aggregatzustand
A crystalline solid
pka
11.56±0.40(Predicted)
Farbe
White to light yellow
InChIKey
HCDMJFOHIXMBOV-UHFFFAOYSA-N
SMILES
C1(=O)N(C2=C(F)C(OC)=CC(OC)=C2F)CC2=CN=C3NC(CN4CCOCC4)=CC3=C2N1CC
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitsschädlich bei Verschlucken. Akute Toxizität oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizität (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P261 Einatmen von Staub vermeiden.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

Pemigatinib Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Pemigatinib is a potent inhibitor of FGFRs for the treatment of cholangiocarcinoma.

Trademarks

Pemazyre

Synthese

Removal of the acetaldehyde protecting group in compound 284 under acidic conditions afforded aldehyde 285. Reductive amination of aldehyde 285 with aniline 286 gave benzylamine 287. Benzylamine 287 reacted with isocyanate 288 to form the desired urea 289. In the presence of a strong base, LHMDS (lithium dimethylsilane), compound 289 underwent intramolecular cyclization to displace the adjacent chlorine atom to yield azatricyclic compound 290. Conventional hydrolysis to remove the benzenesulfonyl group completed the construction of pemitinib, affording the final product in good yield.
Pemigatinib synthesis

IC 50

FGFR1/2/3/4 IC 50 = 0.4, 0.5, 1, 30 nM

Pemigatinib Upstream-Materialien And Downstream Produkte

Upstream-Materialien

2H-Pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one, 3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-1,3,4,7-tetrahydro-8-(4-morpholinylmethyl)-7-(phenylsulfonyl)- 2H-Pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one, 3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-1,3,4,7-tetrahydro-7-(phenylsulfonyl)- 1H-Pyrrolo[2,3-b]pyridine-5-methanamine, N-(2,6-difluoro-3,5-dimethoxyphenyl)-4-(ethylamino)- 2H-Pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one, 3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-1,3,4,7-tetrahydro- 4-(ethylamino)-1H-Pyrrolo[2,3-b]pyridine-5-carboxaldehyde 4-CHLORO-1H-PYRROLO[2,3-B]PYRIDINE-5-CARBALDEHYDE

Downstream Produkte

Pemigatinib Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 132)Lieferanten
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BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. 		+86-18600796368
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Shanghai Daken Advanced Materials Co.,Ltd 		+86-2158073036
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ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 33024 60
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inquiry@bocsci.com United States 19552 58
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354
 marketing@targetmol.com United States 32434 58
Changzhou Xuanming Pharmaceutical Technology Co., Ltd. 		+86-519-85525359 +86-15995072465
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Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471
sales@sarms4muscle.com China 10473 58
Henan Alfa Chemical Co., Ltd 		+8615838112936
 alfa10@alfachem.cn China 12931 58
InvivoChem 		+1-708-310-1919 +1-13798911105
 sales@invivochem.cn United States 6391 58
Beijing Mesochem Technology Co.,Ltd 		+8613651027935
 rachel@mesochem.com China 191 58
  • Pemigatinib
  • 3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(morpholin-4-ylmethyl)-1,3,4,7-tetrahydro-2H-pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one
  • INCB-054828
  • 3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(morpholinomethyl)-1,3,4,7-tetrahydro-2H-pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one
  • 2H-Pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one, 3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-1,3,4,7-tetrahydro-8-(4-morpholinylmethyl)-
  • IBI-375
  • 3-(2,6-Difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(morpholinomethyl)-1,3,4,6-tetrahydro-2H-pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one
  • 2H8]-Pemigatinib
  • INCB 054828,Fibroblast growth factor receptor,INCB-054828,inhibit,cholangiocarcinoma,Orally,Pemigatinib,FGFR,Inhibitor,antineoplastic
  • INCB 54828
  • INCB54828
  • INCB-54828
  • Terbufos Impurity 14 (Ethion)
  • Pemigatinib, 10 mM in DMSO
  • 3-(2,6-Difluoro-3,5-dimethoxyphenyl)-1-ethyl-1,3,4,7-tetrahydro-8-(4-morpholinylmethyl)-2H-pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one
  • 11-(2,6-difluoro-3,5-dimethoxyphenyl)-13-ethyl-4-(morpholin-4-ylmethyl)-5,7,11,13-tetrazatricyclo[7.4.0.02,6]trideca-1,3,6,8-tetraen-12-one
  • 3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(morpholinomethyl)-3,4-dihydro-1H-pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2(7H)-one
  • 1513857-77-6
  • 1513857-77-7
  • C24H27F2N5O4
  • APIS
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