17-α,21-Dihydroxypregna-4,9(11)-dien-3,20-dion-21-acetat
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- CAS-Nr.
- 7753-60-8
- Bezeichnung:
- 17-α,21-Dihydroxypregna-4,9(11)-dien-3,20-dion-21-acetat
- Englisch Name:
- Anecortave Acetate
- Synonyma:
- H6;Anecortave;Pregna-4,9(11)-diene-17-ol-3,20-dione-21-acetate;Al 3789;Retaane;NSC 15475;NSC 24345;Anacorta acetate;Anechota acetate;anecortave acetate
- CBNumber:
- CB5501441
- Summenformel:
- C23H30O5
- Molgewicht:
- 386.48
- MOL-Datei:
- 7753-60-8.mol
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17-α,21-Dihydroxypregna-4,9(11)-dien-3,20-dion-21-acetat Eigenschaften
- Schmelzpunkt:
- 230-234°C
- alpha
- D +117° (c = 1.0 in CHCl3); D22 +124° (c = 1.04 in CHCl3).
- Siedepunkt:
- 551.8±50.0 °C(Predicted)
- Dichte
- 1.23±0.1 g/cm3(Predicted)
- storage temp.
- -20°C Freezer
- Löslichkeit
- Chloroform (Slightly), Methanol (Slightly)
- pka
- 12.47±0.60(Predicted)
- Aggregatzustand
- Solid
- Farbe
- Off-White to Beige
- InChIKey
- YUWPMEXLKGOSBF-GACAOOTBSA-N
- SMILES
- C1(=O)C=C2[C@](C)(CC1)C1[C@]([H])([C@@]3([H])[C@@](CC=1)(C)[C@@](O)(C(=O)COC(C)=O)CC3)CC2
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Achtung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H303 |
May be harmfulif swallowed |
Acute toxicity,oral |
Category 5 |
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P312 |
| H360 |
Kann die Fruchtbarkeit beeinträchtigen oder das Kind im Mutterleib schädigen. |
Fertility (Fruchtbarkeit) |
Kategorie 1 |
Achtung |
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| H373 |
Kann die Organe schädigen bei längerer oder wiederholter Exposition. |
Spezifische Zielorgan-Toxizität (wiederholte Exposition) |
Kategorie 2 |
Warnung |
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P260, P314, P501 |
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| Sicherheit |
| P201 |
Vor Gebrauch besondere Anweisungen einholen. |
| P202 |
Vor Gebrauch alle Sicherheitshinweise lesen und verstehen. |
| P260 |
Dampf/Aerosol/Nebel nicht einatmen. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P312 |
Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P405 |
Unter Verschluss aufbewahren. |
| P501 |
Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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17-α,21-Dihydroxypregna-4,9(11)-dien-3,20-dion-21-acetat Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Anecortave acetate, an angiogenesis inhibitor, was launched
in Australia by Alcon for the treatment of age-related
macular degeneration (AMD). AMD is the leading cause of
untreatable blindness among people aged 65 to 74 years in
the U.S. Worldwide, approximately 20 to 25 million people suffer from AMD, a disease that until recently was untreatable.
Anecortave, an angiostatic steroid, down-regulates the
expression MMP-2 and -9 to exert its antiangiogenic effects.
Chemische Eigenschaften
Off-White Solid
Verwenden
As an angiostatic steroid, Anecortave Acetate can be used in treatment of macular degeneration.
Enzyminhibitor
This novel angiogenesis pro-drug (FW = 386.48 g/mol; CAS 7753-60-8) is taken up and metabolically de-esterified to form the aqnecortave, a synthetic steroid that suppresses the development and elongation of neovascular sprouts and tip cell motility in a VEGF-treated retinal explant model in a dose-dependent manner. Whether used as monotherapy or in combination with sub-therapeutic doses of cisplatin, anecortave acetate significantly controlled tumor burden in a murine retinoblastoma model.
17-α,21-Dihydroxypregna-4,9(11)-dien-3,20-dion-21-acetat Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
17-α,21-Dihydroxypregna-4,9(11)-dien-3,20-dion-21-acetat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 164)Lieferanten
7753-60-8(17-α,21-Dihydroxypregna-4,9(11)-dien-3,20-dion-21-acetat)Verwandte Suche:
- [2-[(8S,10S,13S,14S,17R)-17-hydroxy-10,13-dimethyl-3-oxo-2,6,7,8,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate
- 17-alpha,21-dihydroxypregna-4,9(11)-diene-3,20-dione21-acetate
- 17-Hydroxypregna-4,9(11)-diene-3,20-dione-21-acetate
- anecortave acetate
- Anacorta acetate
- Pregna-4,9(11)-diene-17-ol-3,20-dione-21-acetate
- 17-ALPHA-HYDROXY-3,20-DIOXOPREGNA-4,9(11)-DIENE-21-YL ACETATE
- 21-Acetoxy-17-hydroxypregna-4,9(11)-diene-3,20-dione
- 21-Acetoxy-17α-hydroxypregna-4,9(11)-diene-3,20-dione
- 3,20-Dioxopregna-4,9(11)-diene-17,21-diol 21-acetate
- 3,20-Dioxopregna-4,9(11)-diene-17α,21-diol 21-acetate
- Pregna-4,9(11)-diene-17α,21-diol-3,20-dione 21-acetate
- 17-α,21-dihydroxypregna-4,9(11)-diene-3,20-dione 21-acetate
- 21-(Acetyloxy)-17-hydroxypregna-4,9(11)-diene-3,20-dione
- 21-Acetoxypregna-
4,9(11)-dien-17α-ol-3,20-dione
- Al 3789
- NSC 15475
- NSC 24345
- Retaane
- ANECORTAVE ACETATE (200 MG)F0E2980.997MG/MG(AI)
- Anecortave Acetate[H6]
- Hydrocortisone Acetate EP Impurity E
- Pregna-4,9(11)-diene-3,20-dione, 21-(acetyloxy)-17-hydroxy-
- delta-9(11)-Hydrocortisone Acetate (Anecortave Acetate)
- 17-α,21-dihydroxypregna-4,9(11)-diene-3,20-dione 21-acetate
- Anechota acetate
- 2-((8S,10S,13S,14S,17R)-17-hydroxy-10,13-dimethyl-3-oxo-2,3,6,7,8,10,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate
- Anecortave Acetate (H5)
- 17-Hydroxypregna-4,9(11)-dione-3,20-dione-21-Acetate （H6)
- Acetate Aneconazole
- Hydrocortisone ester
- Hydrocortisone Aceate EP Impurity E
- 17-alpha,21-dihydroxypregna-4,9(11)-diene-3,20-dione 21-acetate(H6)
- Acetic Acid Anacardic
- Hydrocortisone Acetate Impurity 5
- Hydrocortisone Acetate Impurity 5 (Hydrocortisone Acetate EP Impurity E)
- Anecortave
- H6
- Anidulafungin acetate
- 7753-60-8
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Steroids
