Irinotecan hydrochloride trihydrate
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- CAS-Nr.
- 136572-09-3
- Englisch Name:
- Irinotecan hydrochloride trihydrate
- Synonyma:
- Iriontecan HCL;Irinotecan HCL 3H2O;Irinotecan HydrochL;Irinotecan Trihydrate;CPT-11 HCl Trihydrate;Irinotecan Hydrochlorid;IRINOTECAN HCL TRIHYDRATE;IRINOTECON HCL TRIHYDRATE;Irinotecan HCI Trihydrate;trihydrate,(s)-hydrochlorid
- CBNumber:
- CB6122430
- Summenformel:
- C33H45ClN4O9
- Molgewicht:
- 677.18
- MOL-Datei:
- 136572-09-3.mol
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Irinotecan hydrochloride trihydrate Eigenschaften
- Schmelzpunkt:
- 250-256°C (dec.)
- Siedepunkt:
- 257°C(lit.)
- storage temp.
- 2-8°C
- Löslichkeit
- Soluble in DMSO (up to 50 mg/ml), in Water (up to 4 mg/ml) or in Ethanol (up to 4 mg/ml).
- Aggregatzustand
- White solid.
- Farbe
- Yellow
- Wasserlöslichkeit
- Soluble in DMSO at 100mg/ml. Soluble in water at 25mg/ml with warming
- Merck
- 14,5091
- Stabilität:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO, ethanol or distilled water may be stored at -20° for up to 3 months.
- InChIKey
- KLEAIHJJLUAXIQ-VRWBIZLENA-N
- SMILES
- N1(C2CCN(C(OC3C=CC4C(C=3)=C(CC)C3CN5C(C=3N=4)=CC3[C@](CC)(O)C(=O)OCC=3C5=O)=O)CC2)CCCCC1.[H]Cl.[H]O[H].[H]O[H].[H]O[H] |&1:24,r|
- CAS Datenbank
- 136572-09-3(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| R-Sätze: |
22 |
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| S-Sätze: |
20/21-22 |
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| RTECS-Nr. |
DW1060750 |
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| HS Code |
29349990 |
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| Toxizität |
dog,LD50,intravenous,40mg/kg (40mg/kg),Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 953, 1995. |
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| Bildanzeige (GHS) |
 
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| Alarmwort |
Achtung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitsschädlich bei Verschlucken. |
Akute Toxizität oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H372 |
Schädigt bei Hautkontakt und Verschlucken die Organe bei längerer oder wiederholter Exposition. |
Spezifische Zielorgan-Toxizität (wiederholte Exposition) |
Kategorie 1 |
Achtung |
![GHS hazard pictograms]() src="/GHS08.jpg" width="20" height="20" /> |
P260, P264, P270, P314, P501 |
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| Sicherheit |
| P260 |
Dampf/Aerosol/Nebel nicht einatmen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P301+P312 |
BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P314 |
Bei Unwohlsein ärztlichen Rat einholen / ärztliche Hilfe hinzuziehen. |
| P330 |
Mund ausspülen. |
| P403 |
An einem gut belüfteten Ort aufbewahren. |
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Irinotecan hydrochloride trihydrate Chemische Eigenschaften,Einsatz,Produktion Methoden
Chemische Eigenschaften
White powder
Verwenden
Irinotecan Hydrochloride Trihydrate is a DNA topoisomerase inhibitor.
Definition
ChEBI: A hydrate that is the trihydrate form of irinotecan hydrochloride. Onivyde is used in combination with fluorouracil and leucovorin, for the treatment of patients with metastatic adenocarcinoma of the pancreas after disease progression following gemcitabine
based therapy. It is converted via hydrolysis of the carbamate linkage to its active metabolite, SN-38, which is ~1000 times more active.
Hazard
Moderately toxic by ingestion.
Irinotecan hydrochloride trihydrate Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Irinotecan hydrochloride trihydrate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 533)Lieferanten
136572-09-3()Verwandte Suche:
- Irinotecan hydrochloride trihydrate, >=99%
- (1,4’-bipiperidine)-1’-carboxylicacid,4,11-diethyl-3,4,12,14-tetrahydro-4-hyd
- roxy-3,14-dioxo-1h-pyrano(3’,4’:6,7)indolizino(1,2-b)quinolin-9-ylester,mono
- trihydrate,(s)-hydrochlorid
- IRINOTECAN HYDROCHLORIDE TRIHYDRATE
- IRINOTECAN MONOHYDROCHLORIDE TRIHYDRATE
- IRINOTECAN HCL TRIHYDRATE
- Irinotecan HCL 3H2O
- rinotecan hydrochloride trihydrate
- Iriontecan HCL
- CPT 11; CAMPTOSAR; CAMPTO; IRINOTECAN
- (s)-[1,4'-bipiperidine]-1'-carboxylic acid 4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1h-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl ester hydrochloride trihydrate
- Irinotecan Hydrochlorid
- Irinotecanhydrochloridetrihydrate(CPT-11)
- IRINOTECON HCL TRIHYDRATE
- [1,4'-BIPIPERIDINE]-1'-CARBOXYLIC ACID (S)-4,11-DIETHYL-3,4,12,14-TETRAHYDRO-4-HYDROXY-3,14-DIOXO-1H-PYRANO[3',4',6,7]INDOLIZINO[1,2-B]QUINOLIN-9-YL ESTER, HCL TRIHYDRATE
- (S)-[1,4'-Bipiperidine]-1'-carboxylic acid 4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl ester hydrochloride trihydrate ,99%
- Irinotecan Hydrochloride (100 mg)
- Irinotecan Hydrochloride
- Irinotecan Trihydrate
- [1,4'-Bipiperidine]-1'-carboxylicacid,(4S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-ylester,hydrochloride,hydrate(1:1:3)
- Irinotecan HCl Trihydrate (CaMpto)
- Irinotecan, Hydrochloride Salt, Trihydrate
- Irinotecan-d10 hydrochloride trihydrate
- CPT-11 HCl Trihydrate
- irinotecan hydrochloride hydrate
- 7-Ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin Hydrochloride Trihydrate
- Irinotecan hydrochloride trihydrate CRS
- Irinotecan for peak identification
- Irinotican Hydrochloride Trihydrate
- IrinotecanHydrochlorideTrihydrate>
- Irinotecan HydrochL
- Irincan hydrochloride trihydrate
- Irinotecan hydrochloride trihydrate USP/EP/BP
- Irinotican Hydrochloride TrihydrateQ: What is
Irinotican Hydrochloride Trihydrate Q: What is the CAS Number of
Irinotican Hydrochloride Trihydrate Q: What is the storage condition of
Irinotican Hydrochloride Trihydrate Q: What are the applications of
Irinotican Hydrochloride Trihydrate
- Irinotecan for peak identification (Y0001831)
- Irinotecan for system suitability 1 (Y0001830)
- Irinotecan for system suitability 2 (Y0001833)
- Irinotecan Hydrochloride (1347609)
- Irinotecan hydrochloride trihydrate (Y0001832)
- Irinotecan HCI Trihydrate
- (S)-4,11-diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl [1,4'-bipiperidine]-1'-carboxylate hydrochloride trihydrate
- Irinotecan hydrochloride trihydrate 98%
- (S)-4,11-Diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3’,4’:6,7]indolizino[1,2-b]quinolin-9-yl [1,4’-Bipiperidine]-1’-carboxylate Hydrochloride Trihydrate
- Irinotecan (CPT-11) HCl Trihydrate
- Irinotecan hydrochloride trihydrate, 10 mM in DMSO
- Irinotecan hydrochloride trihydrate - Bio-X ?
- 136572-09-3
- 6572-09-3
- 36572-09-3
- C33H38N4O6HCl3H2O
- C33H38N4O6ClH3H2O
- C33H45ClN4O9
- Inhibitors
- Anticancer
- Anti-cancer&immunity
- API
