Sulfathiazol Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
white to cream powder
Verwenden
Sulfonamide antibacterial.
Definition
ChEBI: A 1,3-thiazole compound having a 4-aminobenzenesulfonamido group at the 2-position.
Weltgesundheitsorganisation (WHO)
Sulfathiazole, a sulfonamide anti-infective agent, was introduced
more than 25 years ago for the treatment of bacterial infections. The importance of
sulfonamides has subsequently decreased as a result of increasing bacterial
resistance and their replacement by antibiotics which are generally more active
and less toxic. The sulfonamides are known to cause serious adverse effects such
as renal toxicity, sometimes fatal exfoliative dermatitis and erythema multiforma
and dangerous adverse reactions affecting blood formation such as
agranulocytosis and haemolytic or aplastic anaemia. Although preparations remain
available, use of the drug has been discontinued in many countries.
Allgemeine Beschreibung
White crystalline powder. Is dimorphous: form I is consists of prismatic rods and form II of six-sided plates and prisms. Insoluble in water and soluble in dil aqueous acid and aqueous base.
Air & Water Reaktionen
May be sensitive to heat, air and light during long-term storage . Insoluble in water.
Reaktivität anzeigen
Sulfathiazole is an amino acid.
Brandgefahr
Flash point data for Sulfathiazole are not available, but Sulfathiazole is probably combustible.
Pharmazeutische Anwendungen
2-Sulfanilamidothiazole. A short-acting compound (half-life
c. 4 h) with relatively high activity. Protein binding is c. 75%.
Its use has declined because of a high incidence of side effects.
It is one of the constituents of triple sulfonamide mixtures, of
which local preparations are still available.
Two compounds, phthalylsulfathiazole (sulfathalidine) and
succinylsulfathiazole (sulfasuxidine) owe their activity to the
slow liberation of sulfathiazole in the bowel. They are poorly
soluble and very little is absorbed after oral administration.
They were formerly used in the treatment of intestinal infections
and in bowel preparation before surgery. They are available
in multi-ingredient preparations in some countries.
Sicherheitsprofil
Human poison by
unspecified route. Experimental poison by
intraperitoneal route, Moderately toxic by
intravenous, subcutaneous, and parenteral
routes. Mildly toxic by ingestion. Human
systemic effects by unspecified route:
conjunctiva irritation, tubule changes, and
allergic skin dermatitis. Experimental
reproductive effects. Questionable
carcinogen with experimental tumorigenic
data, Mutation data reported. When heated
to decomposition it emits very toxic fumes
of NOx and SOx.
Sulfathiazol Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
