Sucralfat

Sucralfate Struktur
54182-58-0
CAS-Nr.
54182-58-0
Bezeichnung:
Sucralfat
Englisch Name:
Sucralfate
Synonyma:
SUCRALPHATE;carafate;Keal;Ulcar;Urbal;Sugast;Venter;Citogel;Succosa;Sucrate
CBNumber:
CB6239042
Summenformel:
C11H52Al16O75S8-16
Molgewicht:
2072.71
MOL-Datei:
54182-58-0.mol

Sucralfat Eigenschaften

Schmelzpunkt:
>220°C (dec.)
Siedepunkt:
1990℃ at 101.325kPa
Dichte
0.338 at 20℃
Dampfdruck
0Pa at 25℃
storage temp. 
Inert atmosphere,2-8°C
Löslichkeit
Practically insoluble in water, in ethanol (96 per cent) and in methylene chloride. It dissolves in dilute solutions of mineral acids and alkali hydroxides.
pka
pKa = 0.43 to 1.19(at 25℃)
Aggregatzustand
Solid
Farbe
White
InChIKey
AOVDJNLOYVETHO-MBFTXJLNNA-A
LogP
1.46 at 25℃ and pH7
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
WGK Germany  2
RTECS-Nr. BD0900000
HS Code  29400090
Giftige Stoffe Daten 54182-58-0(Hazardous Substances Data)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitsschädlich bei Verschlucken. Akute Toxizität oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizität (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P261 Einatmen von Staub vermeiden.
P301+P312 BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P302+P352 BEI BERÜHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckmäßig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen.
P304+P340 BEI EINATMEN: Die Person an die frische Luft bringen und für ungehinderte Atmung sorgen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

Sucralfat Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Sucralfate is a complex of the sulfuric acid ester of sucrose and aluminum hydroxide. Secondary polymerization with aluminum hydroxide forms intermolecular bridges between molecules of sulfate esters with aluminum. Limited dissociation of the complex occurs in gastric acid, but these anionic sulfate esters form insoluble adherent complexes with the proteinaceous exudate at the abraded surface of a crater of the ulcerated area in the stomach. This physical complex protects the ulcer from the erosive action of pepsin and bile salts. Sucralfate also stimulates synthesis and release of prostaglandins, bicarbonate, and epidermal and fibroblast growth factors. Significant ulcer healing effects are noted in placebo-controlled trials. Only small amounts of sucralfate are absorbed systemically. In renal impairment, there is a risk of accumulation of absorbed aluminum from the drug. Sucralfate reduces absorption of other drugs, including H2 antihistamines, quinolone antibiotics, phenytoin, and perhaps, warfarin

Chemische Eigenschaften

White Powder

Verwenden

Sucralfate, an aluminum salt of sucrose octasulfate, is used as an antacid and antiulcer medication. Bis- and tris-platinum complexes of sucrose show promise as antitumor agents. Sucrose monoesters are used in some pharmaceutical preparations.

Indications

Sucralfate (Carafate) is an aluminum hydroxide–sulfated sucrose complex that is only minimally absorbed from the GI tract. After exposure to gastric acid, the compound becomes negatively charged, creating a viscous adherent complex. This complex is believed to inhibit back-diffusion of H .Other effects are a direct reduction in pepsin activity and a slight rise in tissue prostaglandin levels. Stimulation of a cytoprotection mechanism may therefore assist mucosal healing. The drug has no acid-buffering capacity.

Allgemeine Beschreibung

Sucralfate, 3,4,5,6-tetra-(polyhydroxyaluminum)-α-D-glucopyranosyl sulfate-2,3,4,5-tetra-(polyhydroxyaluminum)-β-D-fructofuranoside sulfate (Carafate), isthe aluminum hydroxide complex of the octasulfate ester ofsucrose. It is practically insoluble in water and soluble instrong acids and bases. It has a pKa value between 0.43 and1.19.
Sucralfate is minimally absorbed from the GI tract by design,and thus exerts its antiulcer effect through local ratherthan systemic action. It has negligible acid-neutralizing orbuffering capacity in therapeutic doses. Although its mechanismof action has not been established, studies suggestthat sucralfate binds preferentially to the ulcer site to form aprotective barrier that prevents exposure of the lesion to acidand pepsin. In addition, it adsorbs pepsin and bile salts.Either would be very desirable modes of action.
The simultaneous administration of sucralfate may reducethe bioavailability of certain agents (e.g., tetracycline, phenytoin,digoxin, or cimetidine). It further recommends restorationof bioavailability by separating administration of theseagents from that of sucralfate by 2 hours. Presumably, sucralfatebinds these agents in the GI tract. The most frequentlyreported adverse reaction to sucralfate is constipation (2.2%).Antacids may be prescribed as needed but should not be takenwithin 0.5 hour before or after sucralfate.

Clinical Use

Sucralfate is frequently used for prophylaxis of stress-induced gastritis in patients in intensive care units. It has also been successfully used in small numbers of patients as a suspension enema to treat radiation proctitis.

Sucralfat Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Sucralfat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 306)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hebei Chuanghai Biotechnology Co., Ltd
+8617732866630
abby@chuanghaibio.com China 8773 58
RongNa Biotechnology Co.,Ltd
+86-86-13583358881 +8618560316533
Brad@rongnabiotech.com China 3390 58
Hebei Chuanghai Biotechnology Co,.LTD
+86-13131129325
sales1@chuanghaibio.com China 5251 58
Apeloa production Co.,Limited
+8619933239880
admin@apcl.com.cn China 861 58
Watson Biotechnology Co.,Ltd
+86-18186686046 +86-18186686046;
sales01@watsonbiotech.cn China 5762 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21620 55
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29852 58
SHANDONG ZHI SHANG CHEMICAL CO.LTD
+86 18953170293
sales@sdzschem.com China 2930 58
Shaanxi Pioneer Biotech Co., Ltd .
+8613259417953
sales@pioneerbiotech.com China 1287 58
BOC Sciences
+1-631-485-4226
inquiry@bocsci.com United States 19552 58

54182-58-0(Sucralfat)Verwandte Suche:


  • ALUMINUM SUCROSE OCTASULFATE
  • Sucrose Octasulfate Aluminium Salt
  • SUCRALFATE,FINEPOWDER
  • SUCRALFATE,FINEPOWDER,USP
  • SUCRALFATE TABLETS
  • SUCRALPHATE
  • SUCROSE OCTASULFATE - ALUMINUM COMPLEX
  • SUCRALFATE
  • beta-d-fructofuranosyl-alpha-d-glucopyranoside octakis-(hydrogen sulfate) aluminum
  • SUCRALFATE ( MICRONIZED )
  • Hexadeca--hydroxytetracozahydroxy[8-[1,3,4,6-tetra-O-sulpho--D-fructofuranozyl a-D-glucopyranozide tetrax (hydrosulphate(8-)hexadecaaluminum
  • Antepsin
  • Sucrose hydrogen sulfate basic aluminium salt
  • Sucralfate (Sucrose octasulfate-aluminum complex)
  • Sucralfate (FDA)
  • Citogel
  • Hexagastron
  • Keal
  • Succosa
  • Sucralfin
  • Sucrate
  • Sugast
  • Sulcrate
  • Ulcar
  • Urbal
  • hexadeca-u-hydroxytetracosahydroxy-[u8-[1,3,4,6-tetra-o-sulfo-beta-d-fructofur
  • numcomplex
  • sucroseoctakis(hydrogensulfate)aluminumcomplex
  • ulcerban
  • ulcerlmin
  • ulcogant
  • Venter
  • Sucralfate USP
  • AluMinuM,hexadeca-M-hydroxytetracosahydroxy[M8-[[1,3,4,6-tetra-O-sulfo-b-D-fructofuranosyl a-D-glucopyranosidetetrakis(sulfato-kO')](8-)]]hexadeca-
  • )hexadeca-
  • aluminum,hexadeca-u-hydroxytetracosahydroxy(mu8-(1,3,4,6-tetra-o-sulfo-beta-d
  • anosyl-alpha-d-glucopyranosidetetrakis(hydrogensulfato)(8-)]]hexadecaaluminu
  • beta-d-fructofuranosyl-alpha-d-glucopyranosideoctakis-(hydrogensulfate)alumi
  • beta-d-fructofuranosyl-alpha-d-glucopyranosidetetrakis(hydrogensulfato)(8-))
  • carafate
  • -fructofuranosylalpha-d-glucopyranosidetetrakis(hydrogensulfato)(8-)))hexade
  • hexadeca-mu-hydroxytetracosahydroxy(mu(sup8)-(1,3,4,6-tetra-o-sulfo-aluminu
  • [(2R,3R,4S,5R,6R)-2-[[(2R,3R,4S,5S)-3,4-bis($l^{1}-alumanyloxysulfonyloxy)-2,5-bis($l^{1}-alumanyloxysulfonyloxymethyl)-2-oxolanyl]oxy]-3,5-bis($l^{1}-alumanyloxysulfonyloxy)-6-($l^{1}-aluma
  • Sucralfate (Technical Grade)
  • Sucralfate CRS
  • Sucralfate USP/EP/BP
  • Antiacid
  • Sucrose Octasulphate Aluminium Salt (Sucralfate) extrapure
  • Hexadeca-μ-hydroxytetracosahydroxy[μ8-[[1,3,4,6-tetra-O-sulfo-β-D-fructofuranosyl α-D-glucopyranoside tetrakis(sulfato-κO′)](8-)]]hexadecaaluminum
  • Vancomycin hydrochloride 1404-93-9
  • Sucralfate, 10 mM in DMSO
  • Sucralfate, USP grade
  • 54182-58-0
  • 156-2-78
  • C11H52Al16O75S816
  • C12H30Al8O51S88H3AlO3
  • C12H54Al16O75S8
  • C12H14O35S8
Copyright 2019 © ChemicalBook. All rights reserved