Dabigatran etexilate
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- CAS-Nr.
- 211915-06-9
- Englisch Name:
- Dabigatran etexilate
- Synonyma:
- DL-;BIBR-1048;N-[[2-[[[4-[[[(Hexyloxy)carbonyl]aMidino]iMinoMethyl]phenyl]aMino]Methyl]-1-Methyl-1H-benziMidazol-5-yl]carbonyl]-N-2-pyridyl-beta-alanine,ethyl ester;Etexilate;Dabigatran ester;BIBR-1048 (Dabigatran);N-[2-[4-[N-(Hexyloxycarbonyl)aMidino]phenylaMinoMethyl]-1-Methyl-1H-benziMidazol-5-ylcarbonyl]-N-(2-;CS-62;Prazaxa;BIBR 1048
- CBNumber:
- CB62485052
- Summenformel:
- C34H41N7O5
- Molgewicht:
- 627.73
- MOL-Datei:
- 211915-06-9.mol
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Dabigatran etexilate Eigenschaften
- Schmelzpunkt:
- 128-129°
- Dichte
- 1.24±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- Löslichkeit
- DMSO (Slightly), Methanol (Slightly)
- pka
- 9.88±0.46(Predicted)
- Aggregatzustand
- Solid
- Farbe
- White to Pale Yellow
- Stabilität:
- Hygroscopic
- InChIKey
- KSGXQBZTULBEEQ-UHFFFAOYSA-N
- SMILES
- C(OCC)(=O)CCN(C(C1=CC=C2N(C)C(CNC3=CC=C(C(=N)NC(OCCCCCC)=O)C=C3)=NC2=C1)=O)C1=NC=CC=C1
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitsschädlich bei Verschlucken. |
Akute Toxizität oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizität (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P301+P312 |
BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P302+P352 |
BEI BERÜHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckmäßig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
| P304+P340 |
BEI EINATMEN: Die Person an die frische Luft bringen und für ungehinderte Atmung sorgen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen. |
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Dabigatran etexilate Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Dabigatran etexilate is an orally administered pro-drug of dabigatran,
which is a direct inhibitor of thrombin and a potent anticoagulant. The serine protease thrombin is the final mediator in the coagulation cascade
that leads to the production of fibrin, the main protein component of
blood clots. Thrombin is also a potent activator of platelets. Consequently, thrombin inhibitors have found utility as anticoagulants in
treating arterial and venous thrombosis.
Warfarin, although orally available, has a
narrow therapeutic index and requires frequent monitoring and dosage
adjustment. Low-molecular-weight heparins provide better safety profile
and less inter-patient variability; however, these agents are only available
for parenteral administration. Direct thrombin inhibitors (DTIs) are a
new class of anticoagulants that act by directly binding to thrombin at its
catalytic or fibrinogen-binding sites, or both. Unlike the heparins, DTIs do not require the activation of secondary factors such as antithrombin to derive their activity, which makes their action more predictable. In addition, their ability to inhibit both free and clot-bound thrombin predisposes them for enhanced anticoagulation effect.
Verwenden
Dabigatran Etexilate is an oral anticoagulant and direct thrombin inhibitor.
Definition
ChEBI: An aromatic amide obtained by formal condensation of the carboxy group of 2-{[(4-{N'-[(hexyloxy)carbonyl]carbamimidoyl}phenyl)amino]methyl}-1-methyl-1H-benzimidazole-5-carboxylic acid with the secondary amino group of
thyl N-pyridin-2-yl-beta-alaninate. A prodrug for dabigatran, a thrombin inhibitor and anticoagulant which is used for the prevention of stroke and systemic embolism.
Dabigatran etexilate Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Dabigatran etexilate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 462)Lieferanten
211915-06-9()Verwandte Suche:
- N-[[2-[[[4-[[[(Hexyloxy)carbonyl]aMidino]iMinoMethyl]phenyl]aMino]Methyl]-1-Methyl-1H-benziMidazol-5-yl]carbonyl]-N-2-pyridyl-beta-alanine,ethyl ester
- Pradaxa (dabigatran)
- Dabigatran Etexilate (free base)
- Alanine, N-[[2-[[[4-[[[(hexyloxy)carbonyl]aMino]iMinoMethyl]phenyl]aMino]Methyl]-1-Methyl-1H-benziMidazol-5-yl]carbonyl]-N-2-pyridinyl-, ethyl ester
- BIBR-1048(Dabigatran etexilate)
- N-[2-[4-[N-(Hexyloxycarbonyl)aMidino]phenylaMinoMethyl]-1-Methyl-1H-benziMidazol-5-ylcarbonyl]-N-(2-
- BIBR 1048
- BIBR-1048
- Prazaxa
- Dabigatran etexilate
(Dabigatran etexilate methanesulfonate)
- (E)-ethyl 3-(2-((4-(N'-(hexyloxycarbonyl)carbamimidoyl)phenylamino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoate
- BIBR-1048, >=99%
- Ethyl 3-(2-((4-(N-(hexyloxycarbonyl)carbamimidoyl)phenylamino)methyl)-1-methyl-N-(pyridin-2-yl
- 1-methyl-2-[N-[4-(-n-hexyloxycarbonylamidino) phenyl]aminomethyl]benzimidazol-5-yl- carboxylicacid-N-(2-pyridyl)-N- (2-ethoxycarbonylethyl)amide
- N-[2-[4-[N-(Hexyloxycarbonyl)amidino]phenylaminomethyl]-1-methyl-1H-benzimidazol-5-ylcarbonyl]-N-(2-pyridyl)-beta-alanine ethyl ester(Dabigatran etexilate)
- Ethyl 3-(((2-(((4-((((hexyloxy) carbonyl) amino) iminomethyl) phenyl) amino)\methyl)-1-methyl-1H-benzimidazol-5-yl)\carbonyl)(pyridin-2-yl)amino) propanoate
- Dabigatran etexilate
- N-[2-[4-[N-(Hexyloxycarbonyl)amidino]phenylaminomethyl]-1-methyl-1H-benzimidazol-5-ylcarbonyl]-N-(2-pyridyl)-beta-alanine ethyl ester
- phenolsulphophthaleine sodium salt
- PR sodium salt
- Etexilate
- Dabigatran Etexilatr
- BIBR-1048 (Dabigatran)
- CS-62
- BIBR 1048; DABIGATRAN ETEXILATE;BIBR1048
- Dabigatran Free Base
- abigatranetexilate
- Ethyl 3-[2-[[[4-[N-[(Hexyloxy)carbonyl]carbamimidoyl]phenyl]amino]methyl]-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidaz
- Ethyl N-[[2-[[4-[N-[(Hexyloxy)carbonyl]carbamimidoyl]anilino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-beta-alaninate
- Dabigatran etexilate USP/EP/BP
- Hexyl 2-(4-(((5-((3-ethoxy-3-oxopropyl)(pyridin-2-yl)carbamoyl)-1-methyl-1H-benzo[d]imidazol-2-yl)methyl)amino)benzylidene)hydrazinecarboxylate
- Dabigatran ester
- Ethyl 3-(((2-(((4-((((
hexyloxy)carbonyl)amino)iminomethyl)pheny
l)amino)methyl)-1-methy-lH-benzimidazole-5-
yl)carbonyl)(pyridin-2-yl)amino)propanoate/
- N-[2-[4-[N-(Hexyloxycarbonyl)amidino]phenylaminomethyl]-1-me...
- Dabigatran etexilate impurity1516
- Dabigatran EtexilateQ: What is
Dabigatran Etexilate Q: What is the CAS Number of
Dabigatran Etexilate Q: What is the storage condition of
Dabigatran Etexilate Q: What are the applications of
Dabigatran Etexilate
- DL-
- N-[[2-[[[4-[[[(hexyloxy)carbonyl]amino]iminomethyl]phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-β-Alanine, ethyl ester
- Dabigatran etexilate （Mesylat）
- ethyl 3-(2-(((4-(N-((hexyloxy)carbonyl)carbamimidoyl)phenyl)amino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoate
- β-Alanine, N-[[2-[[[4-[[[(hexyloxy)carbonyl]amino]iminomethyl]phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-, ethyl ester
- DBG-3A/DBG-3 (DABIGATRAN IMPURITY)
- DABIGATRAN ETEXILATE 35%, 40.0%, 43%, 50% W/W PELLETS
- Dabigatran Etexilate
N-[[2-[[[4-
[[[(Hexyloxy)carbonyl]amino]iminomethyl]phenyl]amino]methy l]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-β- Alanine Ethyl Ester
- Dabigatran P-1
- Dabigatran (BIBR-1048) etexilate
- 3- (3- (2- (4-cyanoaniline) acetamido) -4- (methylamino) - N - (pyridin-2-yl) benzamido) propionic acid ethyl ester
- ethyl 3-[[2-[[4-[(Z)-N'-hexoxycarbonylcarbamimidoyl]anilino]methyl]-1-methylbenzimidazole-5-carbonyl]-pyridin-2-ylamino]propanoate
- Dabigatran etexilate, 10 mM in DMSO
- Dabigatranetexilatebase
- Dabigatron
- Dabigatran etexilate - Bio-X ?
- Ethyl 3-{[(2-{[(4-{N'-[(Hexyloxy) carbonyl] carbamimidoyl} phenyl)
amino]methyl}-l-methyl- lH-benzimidazol-5-yl)carbonyl] (2- pyridinyl)amino} propanoate
- (5-bromo-2-methylphenyl)(5-(4-fluorophenyl)thiophen-2-yl)methanone (Intermediate of Canagliflozin)
- 211915-06-9
- C34H41N7O5
- Pharmaceutical intermediate
- API
