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(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid

(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid Struktur
1012341-50-2
CAS-Nr.
1012341-50-2
Englisch Name:
(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid
Synonyma:
(2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)aMino]-2-Methylpentanoic acid;(2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl) amino]-2-methylpentanoic acid AHU84;AHU;sacubitril intermediate;AHU08;4S)-5-([1;LCZ696-24;LCZ696S-01;LCZ696 INT;LCA696 inter
CBNumber:
CB62723688
Summenformel:
C23H29NO4
Molgewicht:
383.48
MOL-Datei:
1012341-50-2.mol
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(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid Eigenschaften

Schmelzpunkt:
145-147°C
Siedepunkt:
582.6±50.0 °C(Predicted)
Dichte
1.115±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
Löslichkeit
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly, Sonicated)
pka
4?+-.0.23(Predicted)
Aggregatzustand
Solid
Farbe
White to Off-White
InChI
InChI=1/C23H29NO4/c1-16(21(25)26)14-20(24-22(27)28-23(2,3)4)15-17-10-12-19(13-11-17)18-8-6-5-7-9-18/h5-13,16,20H,14-15H2,1-4H3,(H,24,27)(H,25,26)/t16-,20+/s3
InChIKey
YNELJETWNMPEEH-OXDNQSQGNA-N
SMILES
C(O)(=O)[C@H](C)C[C@H](NC(OC(C)(C)C)=O)CC1=CC=C(C2=CC=CC=C2)C=C1 |&1:3,6,r|
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitsschädlich bei Verschlucken. Akute Toxizität oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizität (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P261 Einatmen von Staub vermeiden.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid is a pharmaceutical intermediate compound that can be used to synthesize Sacubitril, a neprilysin inhibitor used as an adjuvant drug in combination with valsartan to reduce the risk of cardiovascular death and heart failure hospitalization in patients with chronic heart failure (NYHA class II-IV) and reduced ejection fraction.

Synthese

Dissolve 2g [Ru] catalyst (diiodo(p-cymene) ruthenium(II) dimer) and 1.3g (R,R)-Me-Duphos in 20mL toluene, and react at 65-70 for one hour , Prepared as a chiral catalyst. Add the toluene solution of the above chiral catalyst into a clean hydrogenation kettle, and sequentially add SM1 (763g), 202g triethylamine, and 16L methanol solvent, and then seal the hydrogenation kettle to replace the nitrogen for three times and then replace the hydrogen for three times (0.4-0.5MPa) The reaction was carried out at 55°C for 12 hours under pressure, and the reaction liquid was taken for liquid phase detection. The conversion rate of reaction SM1 reached 99.99%. The reaction solution is filtered and concentrated, and the pure (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid can be obtained by beating with n-hexane and ethyl acetate (1:1); the yield is 96.1%, and the product is an off-white solid.

(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

AHU377-BOC double button LCZ699 Impurity 598-11 1-Pyrrolidinecarboxylic acid, 5-([1,1'-biphenyl]-4-ylmethyl)-3-methyl-2-oxo-, 1,1-dimethylethyl ester, (3R,5S)- (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-aMino-2-Methylpentanoic acid hydrochloride (R,E)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpent-2-enoic acid

Downstream Produkte

(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 424)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Changsha Junyu Chemexpress.co., Ltd
+86-13723890100
 info@csjyyy.cn China 134 58
Jiangsu Yutian pharmaceutical Co.,Ltd.
+undefined-0518-86098006 +undefined19851887368
 lvan.hui@jsytsw.com China 80 58
Zhejiang guotuohuanuo pharmatech Co.,Ltd,
+86-18600013947
prp336019@vip.163.com China 31 58
Hebei Yanxi Chemical Co., Ltd. 		+8618531123677
 faithe@yan-xi.com China 5853 58
Henan Bao Enluo International TradeCo.，LTD 		+86-17331933971
deasea125996@gmail.com China 2472 58
Hebei Zhuanglai Chemical Trading Co Ltd 		+86-16264648883
niki@zlchemi.com China 7245 58
Hebei Junhua Import and Export Co., LTD 		+85259680964
 junhua1@hb-junhua.com China 933 58
Capot Chemical Co.,Ltd. 		+8613336195806
 sales@capot.com China 29734 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-2158073036
info@dakenam.com China 13090 58
Nanjing Gold Pharmaceutical Technology Co. Ltd. 		025-84209270 15906146951
CHINA 115 55

1012341-50-2()Verwandte Suche:

Ethyl-2-(triphenylphosphoranyliden)propionat
  • (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid
  • LCZ696 inter.
  • LCZ-696-001-SS
  • LCZ696-24
  • (2R,4S)-5-(4-Biphenylyl)-4-(Boc-amino)-2-methylpentanoic Acid
  • (2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl) amino]-2-methylpentanoic acid AHU84
  • (2R, 4S) -5- (biphenyl-4-yl) -4-[(tert-butoxycarbonyl) amino] -2-methylvaleric acid
  • LCZ696S-01
  • AHU08
  • 1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid
  • 4S)-5-([1
  • (2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic acid [DMF No. 031502]
  • (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic aci
  • (2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)aMino]-2-Methylpentanoic acid
  • (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic
  • LCZ696 INT
  • [1,1'-Biphenyl]-4-pentanoic acid, γ-[[(1,1-dimethylethoxy)carbonyl]amino]-α-methyl-, (αR,γS)
  • sacubitril intermediate
  • (2R,4S)-2-methyl-4-[(2-methylpropan-2-yl)oxycarbonylamino]-5-(4-phenylphenyl)pentanoic acid
  • LCA696 inter
  • (2R,4S)-5-(4-Biphenylyl)-2-methyl-4-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)pentanoic acid
  • AHU
  • (2R, 4S) -5- ([1,1'-]-4- based -4- (biphenyl) (TERT butoxycarbonyl) amino) -2- methyl valerate
  • LCZ-696 Intermediate 40(R,R)
  • 1,1'-Biphenyl]-4-pentanoic acid, γ-[[(1,1-dimethylethoxy)carbonyl]amino]-α-methyl-, (αR,γS)-
  • (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid ISO 9001：2015 REACH
  • LCZ696 intermediates，(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4- ((tert-butoxycarbonyl)amino)-2- methylpentanoic acid
  • Valsartan Impurity 80
  • (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)ami...
  • LCZ696 impurities123
  • (2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic acidQ: What is (2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic acid Q: What is the CAS Number of (2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic acid Q: What is the storage condition of (2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic acid Q: What are the applications of (2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic acid
  • the intermidiate of AHU-377
  • Sacubitril-Valsartan Hydrate
  • (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxy
  • LCZ-696 Intermediate 40
  • 2-PYRIMIDINEMETHANOL,7-HYDROXY
  • Propanoicacid,3-cyano-2-[[(1,1-dimethylethoxy)carbonyl]amino]-,(7S)-
  • (2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-meth
  • Salcubatra calcium impurity 14
  • (αR,γS)-γ-[[(1,1-Dimethylethoxy)carbonyl]amino]-α-methyl[1,1'-biphenyl]-4-pentanoic acid
  • (2R,4S)-5-((2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid
  • SACUBITRIL N-BOC ACID (SAV-2)
  • Entresto intermediate N-3
  • LCZ696 Intermediate N-3
  • Sacubitril intermediates (2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic acid
  • (2R,4S)-5-([1,1'-biphenyl]-4-y1)-4-((tert-butoxycarbonyl) amino)-2-methylpentanoic acid
  • LCZ696 valsartan + sacubitril Impurity 52
  • (2R,4S)-5-[Biphenyl-4-(tert-butoxycarbonyl)amino]-2-methylpentanoicacid
  • (2R,4S)-5-(4-Biphenylyl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoicacid
  • [1,1'-Biphenyl]-4-pentanoicacid,γ-[[(1,1-dimethylethoxy)carbonyl]amino]-α-methyl-,(αR,γS)-
  • (αR,γS)-γ-[[(1,1-Dimethylethoxy)carbonyl]amino]-α-methyl[1,1'-biphenyl]-4-pentanoic acid
  • (2R,4S)-5-([1,1'-Biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid - [B15994]
  • (2R,4S)-5-(biphenyl-4-base)-4-[(tert-Butoxycarbonyl)amino ]-2-Methylvaleric acid
  • (2R,4S)-5-(Biphenyl-4-yl)-4-(tert-butoxycarbonylamino)-2-methylpentanoic acid (Intermediate of Sacubitril Valsartan Sodium)
  • 1012341-50-2
  • 1
  • intermediates
  • intermediate
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