Clonidin
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- CAS-Nr.
- 4205-90-7
- Bezeichnung:
- Clonidin
- Englisch Name:
- CLONIDINE
- Synonyma:
- Clonidin;CLONIDINE BASE;Kapvay;734571A;m-5041t;Arkamin;Nexiclon;ST-155-BS;Catapress;CLONIDINE
- CBNumber:
- CB6505769
- Summenformel:
- C9H9Cl2N3
- Molgewicht:
- 230.09
- MOL-Datei:
- 4205-90-7.mol
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Clonidin Eigenschaften
- Schmelzpunkt:
- 141-142℃
- Siedepunkt:
- 369.21°C (rough estimate)
- Dichte
- 1.3946 (rough estimate)
- Brechungsindex
- 1.6300 (estimate)
- Flammpunkt:
- 9℃
- storage temp.
- -20°C
- Löslichkeit
- DMSO:100.0(Max Conc. mg/mL);434.61(Max Conc. mM)
- Aggregatzustand
- Solid
- pka
- 8.10±0.50(Predicted)
- Farbe
- White to Off-White
- Henry's Law Constant
- 6.6×105 mol/(m3Pa) at 25℃, HSDB (2015)
- Major Application
- pharmaceutical (small molecule)
- InChI
- 1S/C9H9Cl2N3/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9/h1-3H,4-5H2,(H2,12,13,14)
- InChIKey
- GJSURZIOUXUGAL-UHFFFAOYSA-N
- SMILES
- Clc1c(c(ccc1)Cl)NC2=NCCN2
- CAS Datenbank
- 4205-90-7(CAS DataBase Reference)
- EPA chemische Informationen
- 1H-Imidazol-2-amine, N-(2,6-dichlorophenyl)-4,5-dihydro- (4205-90-7)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Kennzeichnung gefährlicher |
F,T |
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| R-Sätze: |
11-23/24/25-39/23/24/25 |
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| S-Sätze: |
16-36/37-45 |
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| RIDADR |
UN1230 - class 3 - PG 2 - Methanol, solution |
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| WGK Germany |
1 |
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| HS Code |
2933290000 |
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| Speicherklasse |
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects |
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| Hazard Classifications |
Acute Tox. 3 Oral |
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| Giftige Stoffe Daten |
4205-90-7(Hazardous Substances Data) |
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| Toxizität |
LD50 oral in rat: 67300ug/kg |
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| Bildanzeige (GHS) |
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| Alarmwort |
Achtung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H301 |
Giftig bei Verschlucken. |
Akute Toxizität oral |
Kategorie 3 |
Achtung |
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P264, P270, P301+P310, P321, P330,P405, P501 |
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| Sicherheit |
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Clonidin Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Clonidine
may be useful in the treatment of acute opioid withdrawal. Epidural
clonidine 1–2μgkg –1 increases the duration and potency of analgesia
provided by epidural opioid or local anaesthetic drugs.
Definition
ChEBI: A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
Pharmakokinetik
Clonidine is lipid soluble and rapidly absorbed after oral administration,
with a peak plasma concentration occurring in 60–90min. O ral, intravenous
and intramuscular routes may be used for sedation or analgesia. I n addition,
epidural and intrathecal clonidine is used to augment regional anaesthesia,
but perineural administration is of limited or no effect. The elimination halflife
is 9–13h and is prolonged in renal failure. Fifty percent of an
administered dose is excreted unchanged by the kidneys, and 50% is
metabolised in the liver to inactive metabolites.
Stoffwechselwegen
Clonidine is well absorbed orally, with peak plasma
concentrations after 60–90min. I t is highly lipid soluble, and approximately
50% is metabolised in the liver to inactive metabolites; the rest is excreted
unchanged via the kidneys, with an elimination half-life of 9–12h.
Clonidin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Clonidin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 120)Lieferanten
4205-90-7(Clonidin)Verwandte Suche:
- CLONIDINE (200 MG)
- clonidine (amino form)
- clonidine (imino form)
- 2-((2,6-dichlorophenyl)amino)-2-imidazoline
- 2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2)
- 2-(2,6-dichloroanilino)-2-imidazolin
- 2-(2,6-dichloroanilino)-2-imidazoline
- 2-(2,6-Dichlorophenylamino)-2-imidazoline
- 2,6-dichloro-n-2-imidazolidinylidene-benzenamin
- 2,6-dichloro-n-2-imidazolidinylidenebenzenamine
- 2-[(2,6-Dichlorophenyl)imino]imidazolidine
- 2-[(2,6-Dichlorophenyl)imino]imidazoline
- 2-Imidazoline, 2-(2,6-dichloroanilino)-
- 734571A
- Clonidine (base and/or unspecified salts)
- Clonidine solution
- 1H-Imidazol-2-amine, N-(2,6-dichlorophenyl)-4,5-dihydro-
- Benzenamine, 2,6-dichloro-N-2-imidazolidinylidene-
- Catapres-TTS
- m-5041t
- n-(2,6-dichlorophenyl)-4,5-dihydro-1h-imidazol-2-amin
- N-(2,6-Dichlorophenyl)-4,5-dihydro-1H-imidazol-2-amine
- ST-155-BS
- 2,6-dichloro-N-(2-imidazolin-2-yl)aniline
- ClonidinHCl
- Clonidinhydrochlorid
- ClonidineHCI-4,4,5,5(-imidazoline-D4)
- CLONIDINE,1.0MG/MLINMETHANOL
- ClonidineCI-4,4,5,5(-imidazoline-D4)
- Arkamin
- Catapress
- Catapressan
- Kapvay
- Nexiclon
- CLONIDINE
- CLONIDINE USP/EP/BP
- Clonidine (1140393)
- Clonidine,α2-adrenergic,inhibit,Inhibitor,anesthesia,Adrenergic Receptor,Beta Receptor
- Clonidine
2,6-Dichloro-N-(imidazolidin-2-ylidene)aniline
- CLONIDINE BASE
- Clonidin
- 4205-90-7
- C9H9Cl2N3
- C9H5D4N3Cl2HCl
