Natrium-2-[(2,6-dichlor-3-methylphenyl)amino]benzoat Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Meclofenamate is a time-
dependent, non-
specific competitive inhibitor of COX-
1 and -
2. The IC
50 values for inhibition of human recombinant COX-
1 and -
2 are 1.5 and 9.7 μM, respectively for instantaneous inhibition. However, the IC
50 is much lower if pre-
incubated with the enzyme.
Verwenden
Meclofenamate Sodium is an NSAID used in the treatment of chronic pain.
Definition
ChEBI: An organic sodium salt derived from meclofenamic acid. Its monohydrate is used for the treatment of dysmenorrhoea (painful periods), osteoarthritis and rheumatoid arthritis.
Indications
Meclofenamate sodium (Meclomen) is
prescribed for rheumatoid arthritis and osteoarthritis.
The fenamates show no clear superiority in antiinflammatory
activity and may produce more adverse
effects than other NSAIDs.
Allgemeine Beschreibung
Meclofenamate sodium (Meclomen) is available for use inthe treatment of acute and chronic RA, OA, and primarydysmenorrhea. It is metabolized in a similar manner tomefenamic acid discussed above, thus a similar restriction isalso applied to meclofenamate. The most significant side effectsare GI, including diarrhea.
Pharmakokinetik
Meclofenamate sodium is rapidly and almost completely absorbed following oral administration, reaching peak plasma
levels within 2 hours. It is highly bound to plasma proteins (99%) and has a plasma half-life of 2 to 4 hours.
Metabolism involves oxidation of the methyl group, aromatic hydroxylation, monodehalogenation, and conjugation.
Urinary excretion accounts for approximately 75% of the administered dose. The major metabolite is the product of
3′-methyl oxidation and has been shown to possess anti-inflammatory activity.
Clinical Use
Meclofenamate sodium is indicated for the relief of mild to moderate pain, the acute and chronic treatment of
rheumatoid arthritis and osteoarthritis, the treatment of primary dysmenorrhea, and the treatment of idiopathic, heavy
menstrual blood loss.
Natrium-2-[(2,6-dichlor-3-methylphenyl)amino]benzoat Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
