N2,N6-Dibenzyloxycarbonyl-L-lysin
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- CAS-Nr.
- 405-39-0
- Bezeichnung:
- N2,N6-Dibenzyloxycarbonyl-L-lysin
- Englisch Name:
- Z-Lys(Z)-OH
- Synonyma:
- Z-LYS(Z);Z-Lys;CBZ-LYS(CBZ)-OH;Cbz-Lys(Z)-OH;NSC 88474;Z-LYS(Z)-OH;Z-Lys(Z)-0H;Z-L-Lys(Z)-OH;Z-Glu(Orb)-OH;Z-LYSINE(Z)-OH
- CBNumber:
- CB7208816
- Summenformel:
- C22H26N2O6
- Molgewicht:
- 414.45
- MOL-Datei:
- 405-39-0.mol
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N2,N6-Dibenzyloxycarbonyl-L-lysin Eigenschaften
- Schmelzpunkt:
- 76-78°C
- Siedepunkt:
- 659.0±55.0 °C(Predicted)
- Dichte
- 1.238±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- Löslichkeit
- DMSO (Slightly), Methanol (Slightly)
- Aggregatzustand
- Solid
- pka
- 3.97±0.21(Predicted)
- Farbe
- White to Off-White
- BRN
- 1897206
- Major Application
- peptide synthesis
- InChIKey
- BLZXFNUZFTZCFD-IBGZPJMESA-N
- SMILES
- C(O)(=O)[C@H](CCCCNC(OCC1=CC=CC=C1)=O)NC(OCC1=CC=CC=C1)=O
- CAS Datenbank
- 405-39-0(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| WGK Germany |
3 |
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| Speicherklasse |
11 - Combustible Solids |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitsschädlich bei Verschlucken. |
Akute Toxizität oral |
Kategorie 4 |
Warnung |
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P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
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P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
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P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizität (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen. |
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N2,N6-Dibenzyloxycarbonyl-L-lysin Chemische Eigenschaften,Einsatz,Produktion Methoden
Chemische Eigenschaften
White Solid
Verwenden
Protected L-lysine
Definition
Z-Lys(Z)-OH is a lysine derivative.
Synthese
A 250 mL three-necked flask was loaded consecutively with water (20 mL), 1,4-dioxane (20 mL), and L-lysine (2.1 g, 14.4 mmol). The mixture was stirred until complete dissolution. The pH was adjusted to about 10.5 by the addition of 30% NaOH. Benzyl chloroformate (5.2 g, 30.6 mmol) was added while maintaining the pH at about 1011 by adding at the same time 30% NaOH. At the end of the addition, the reaction was stirred at 20° C. for about 1 hour. The pH was adjusted to 5 with 37% HCl. Ethyl acetate (30 mL) was added and the pH was adjusted to 1 with 37% HCl. The mixture was stirred at room temperature for about 30 minutes, the organic layer was separated and the aqueous layer was extracted with ethyl acetate (20 mL). The combined organic layer was washed with brine (30 mL) and dried over Na2SO4. Then, the solvent was evaporated to yield Z-Lys(Z)-OH as a yellowish oil (6.0 g, 99%).
N2,N6-Dibenzyloxycarbonyl-L-lysin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
N6-Benzyloxycarbonyl-L-lysin
Thiosulfuric acid,anhydride with phenylmethyl carbonothioate, sodium salt (1:1)
L-Lysine, N6-[(phenylmethoxy)carbonyl]-, methyl ester
L-Lysine, N2,N6-bis[(phenylmethoxy)carbonyl]-, 1,1-dimethylethyl ester
Carbonic acid, phenylmethyl 8-quinolinyl ester
L-Lysine, N2,N6-bis[(phenylmethoxy)carbonyl]-, methyl ester
4-HYDROXYPHENYLDIMETHYLSULFONIUM METHYL SULFATE
Chlormethylbenzoat
L-Lysin
Benzylchlorformiat
Downstream Produkte
N2,N6-Dibenzyloxycarbonyl-L-lysin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 227)Lieferanten
405-39-0(N2,N6-Dibenzyloxycarbonyl-L-lysin)Verwandte Suche:
- DI-N-CBZ-L-LYSINE
- DICARBOBENZOXY-L-LYSINE
- Z-LYSINE(Z)-OH
- Z-LYS(Z)-OH
- N-ALPHA,EPSILON-BIS-Z-L-LYSINE
- N-ALPHA,N-EPSILON-DI-Z-L-LYSINE
- N-ALPHA, N-EPSILON-DIBENZYLOXYCARBONYL-L-LYSINE
- N-ALPHA-N-EPSILON-DICARBOBENZOXY-L-LYSINE
- N-ALPHA-N-EPSILON-DI-CBZ-L-LYSINE
- N,N'-DI-CBZ-L-LYSINE
- Nα,Nε-Di-Z-L-lysine
- di-N-CBZ-L-Lysine di-N-Carbobenzyloxy-L-lysine
- Cbz-L-Lys(Cbz)-OH
- Nα,ε-Bis-Z-L-lysine≥ 99% (HPLC)
- (2S)-2,6-bis(phenylmethoxycarbonylamino)hexanoic acid
- N,N-di-cbz-L-lysine free acid
- N2,N6-dibenzyloxycarbonyl-L-lysine
- NA,NE-DIBENZYLOXYCARBONYL-L-LYSINE
- L-Lysine, N2,N6-bis[(phenylmethoxy)carbonyl]-
- N1,N6-DI-CBZ-L-LYSINE
- N,N'-di-carbobenzyloxy-L-lysine
- N,Nμ-Di-Cbz-L-lysine, Nα,Nε-Di-Z-L-lysine
- N2,N6-Bis(benzyloxycarbonyl)-L-lysine
- N2,N6-Bis(benzyloxycarbonyl)lysine
- N2,N6-Bis[(benzyloxy)carbonyl]-L-lysine
- Nα,Nε-Bis(benzyloxycarbonyl)-L-lysine
- N,N'-Dibenzyloxycarbonyl-L-lysine
- N-alpha-N-epsilon-Bis-benzyloxycarbonyl-L-lysine
- Z-L-Lys(Z)-OH
- N-beta,epsilon-Bis-Z-L-lysine
- N,N'-(Dicarobenzyloxy)-L-lysine
- N2,N6-Bis[(phenylMethoxy)carbonyl]-L-lysine
- N2,N6-Dicarbobenzoxy-L-lysine
- NSC 88474
- N2,N6-Bis-Cbz-L-lysine
- ZzLys[Z-Lys(Z)-OH]
- (S)-2,6-Bis(((benzyloxy)carbonyl)aMino)hexanoic acid
- Z-Lys(Z)-OH, 98%+
- Z-Lys(Z)-OH >=98.0% (TLC)
- (2S)-2,6-di{[(benzyloxy)carbonyl]amino}hexanoic acid
- (2S)-2,6-bis(phenylmethoxycarbonylamino)hexanoicaci
- Z-LYS(Z)-OH USP/EP/BP
- Nα,ε-Bis-Z-L-lysine
- TIANFUCHEM--405-39-0--High purity Z-LYS(Z)-OH factory price
- N2,N6-Dibenzyloxycarbonyl-L-lysin
- N,N'-Bis(benzyloxycarbonyl)-L-lysine
- N,N'-DICARBOBENZYLOXY-L-LYSINE
- Nα,Nω-Bis(benzyloxycarbonyl)-L-lysine
- Z-Lys(Z)-0H
- Cbz-Lys(Z)-OH
- CBZ-LYS(CBZ)-OH
- Z-LYS(Z)
- Z-Lys
- Z-Glu(Orb)-OH
- 405-39-0
- C6H5CH2O2CNHCH24CHNHCO2CH2C6H5CO2H
- CARBOXYLIC ACID
- Peptide Synthesis
