2'-Desoxycytidin

2'-Desoxycytidin Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:

S24/25:Berührung mit den Augen und der Haut vermeiden.

Chemische Eigenschaften

White crystalline powder

Definition

ChEBI: A pyrimidine 2'-deoxyribonucleoside having cytosine as the nucleobase.

Allgemeine Beschreibung

2′-Deoxycytidine (deoxyC) is one of the deoxynucleosides containing cytosine as the nucleobase. It is found in the blood, feces, and urine.

Cytotoxicity

JC-1 staining was performed to determine the cytotoxic effect of 2-DC on UC-MSCs. UC-MSCs were cultured in complete DMEM and treated with the different concentrations (10, 20, 40, 60, 80, and 100 μM) of 2-DC for 24 h. Unlabeled MSCs were used as a negative control, while MSCs labelled only with JC-1 stain were used for calibrating the instrument and optimizing the protocol. Cells were harvested, washed, and stained with JC-1 dye for 15 min at 37 °C. Cells were washed with PBS and resuspended in PBS. Analysis was performed through fow cytometry. Data was acquired and analyzed using BD CellQuest pro software. UC-MSCs treated with different concentrations of 2-DC and stained with JC-1 dye showed that 2-DC did not have any significant cytotoxic effect at any of these concentrations[1].

Sicherheitsprofil

Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.

läuterung methode

Purify 2'-deoxycytidine by recrystallisation from MeOH/Et2O or EtOH and dry it in air. [NMR: Miles J Am Chem Soc 85 1007 1963, UV: Fox & Shugar Biochim Biophys Acta 9 369 1952.] The hydrochloride crystallises from H2O/EtOH and has m 174o(dec, 169-173o). [Walker & Butler Can J Chem 34 1168 1956.] The picrate has m 208o(dec). [Fox et al. J Am Chem Soc 83 4066 1961, Beilstein 25 III/IV 3662.]

Structure and conformation

2'-Deoxycytidine monohydrate (dCMP) is a nucleoside phosphate in being comprised of a deoxyribonucleoside and one phosphate group. It has a deoxyribose as its sugar constituent with one phosphate group attached. Its nucleoside contains a pyrimidine base, i.e., a cytosine attached to the deoxyribose sugar. It has only one phosphate group attached to the nucleoside. Its conjugate acid form is deoxycytidylic acid, whereas its conjugate base form is deoxycytidylate. dCMP, instead of having a hydroxyl group on the 2′ carbon of the sugar component as it is in Cytidine monophosphate (CMP), has it reduced to a hydrogen atom (thus, deoxy- in its name). dCMP is one of the monomeric units that constitute DNA, whereas CMP is one of the monomeric units that make up RNA.

2'-Desoxycytidin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

2'-Desoxycytidin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Chemtour Biotech Co., Ltd	+8617327281506	market@chemtour.com	China	1521	58
Xinxiang Aurora Biotechnology Co.,Ltd.	+86-0086-0373-3088722 +8618637352520	info@aurora-biotech.com	China	112	58
Allbiosyn Biotechnology Co.,Ltd.	+8618666985712	info@allbiosyn.com	China	295	58
INNOBIO PHARM CO.,LTD	+8615600141006	cindyyb@126.com	China	273	58
Zhengzhou Youmei Medical Technology Co., Ltd.	+8615716484486	495737714@qq.com	China	7	58
WeiTai BioPharmaceutical Co.,Ltd(Hangzhou?)	+86-86-057182358004 +8613588879771	info@weitai-pharmaceutical.com	China	61	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8772	58
Sichuan Zhuoyu Yantang Technology Co., Ltd.	+8613288715578	sales@sichuanzyyt.com	China	12247	58
HangZhou RunYan Pharma Technology Co.,LTD.	+8618882027439	sales2@runyanpharma.com	China	302	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29734	60

951-77-9(2'-Desoxycytidin)Verwandte Suche:

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• 2(1H)-Pyrimidinone, 4-amino-1-(2-deoxy-beta-D-erythro-pentofuranosyl)-
• 2'-DEOXYCYTIDINE FREE BASE
• 4-amino-1-[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-pyrimidin-2-one
• 2''-Deoxycytidine (and/or unspecified salts)
• 2'-Deoxycytidine monohydrate
• 2''-DEOXYCYTIDINE (CYTOSINE): (DEOXYRIBOSIDE)
• 2-DEOXYCYTIDINE extrapure
• 2'-Deoxycytidine ,98%
• 2-Deoxycystidine
• 2'-Deoxycytidine(dC)
• 1-(2-Deoxy-β-D-ribofuranosyl)cytosine
• 4-AMino-1-(2-deoxy-β-D-erythro -pentofuranosyl)-2(1H)-pyriMidinone
• 4-AMino-1-((2R,4S,5R)-4-hydroxy-5-(hydroxyMethyl)tetrahydrofuran-2-yl)pyriMidin-2(1H)-one
• 1-(2-Deoxy-beta-D-ribofuranosyl)cytosine dC
• (2R,3R,4S,5R)-2-(4-aMino-1,2-dihydropyriMidin-1-yl)-5-(hydroxyMethyl)oxolane-3,4-diol
• 3,N4-Etheno-2&rsquo
• 5,6-Dihydro-5-aza-2&rsquo
• N4-[(Dimethylamino)methylidene]-5-[3-oxo-[[6-[(trifluoroacetyl)amino]hexyl]amino]-1-propenyl]-2&rsquo
• -deoxy-6-oxo Cytidine
• 2’-deoxy-cytidin
• Cytidine, 2'-deoxy-
• Cytosine deoxyribonucleoside
• Cytosine, 1-(2-deoxy-beta-D-erythro-pentofuranosyl)-
• cytosine,deoxyribonucleoside
• dCyd
• deoxycytidine
• Deoxyribose cytidine
• deoxyribosecytidine
• Desoxycytidine
• 2'-DEOXY-D-CYTIDINE
• DC
• CYTOSINE DEOXYRIBOSIDE
• 1-(2'-DEOXY-BETA-D-RIBOFURANOSYL)CYTOSINE
• 2&apos
• 4-amino-1-(4-hydroxy-5-methylol-tetrahydrofuran-2-yl)pyrimidin-2-one
• 4-amino-1-[(2R,4S,5R)-4-hydroxy-5-
• 4-amino-1-[4-hydroxy-5-(hydroxymethyl)-2-tetrahydrofuranyl]-2-pyrimidinone
• 4-amino-1-[4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidin-2(1H)-one
• 4-amino-1-[4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidin-2-one
• Deoxycytidine-2-14C
• -deoxyuridine (&beta
• Isomer Only)
• 5-Aza-2&rsquo
• N4-Benzoyl-5-(furan-2-yl)-2&rsquo
• -Deoxycytidine monohydrate
• Cytarabine Impurity 20（2'-Deoxycytidine）
• N4-Ethyl-2&rsquo
• 5-[(2-Cyanoethoxy)methyl]-2&rsquo
• 2-Thio-2&rsquo
• 5-Chloro-2&rsquo
• 4-Amino-1-(2-deoxy-B-D-erythropentofuranosyl)-1,3,5-triazin-2(1H)-one)
• Decitabine, DNA Methyltransferase Inhibitor|(5-Aza-2&rsquo
• -Deoxy-5-azacytidine
• 5-Carboethoxy-2&rsquo
• Deoxycytidine Deoxycytidine
• 2'-Deoxycytidine>
• 2'-Deoxycytidine monohydrate USP/EP/BP
• 951-77-9 USP/EP/BP