Natriumhydrogen-[R-[R*,S*-(Z)]]-7-[(2-amino-2-carboxylatoethyl)thio]-2-[[(2,2-dimethylcyclopropyl)carbonyl]amino]hept-2-enoat
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- CAS-Nr.
- 81129-83-1
- Bezeichnung:
- Natriumhydrogen-[R-[R*,S*-(Z)]]-7-[(2-amino-2-carboxylatoethyl)thio]-2-[[(2,2-dimethylcyclopropyl)carbonyl]amino]hept-2-enoat
- Englisch Name:
- Cilastatin sodium
- Synonyma:
- Cilastatine;l642957;Cilastatin sodium;Sodium Cilastatin;Cilastatin Impurity 9;Cilastatin sodium CRS;Cilastatin sodium (C2170000);13C3,2H3,15N]-Cilastatin sodium;Cilastatin sodium salt - Bio-X ?;Cilastatin sodium 100 μg/mL in Water
- CBNumber:
- CB8260633
- Summenformel:
- C16H25N2O5S.Na
- Molgewicht:
- 381.44
- MOL-Datei:
- 81129-83-1.mol
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Natriumhydrogen-[R-[R*,S*-(Z)]]-7-[(2-amino-2-carboxylatoethyl)thio]-2-[[(2,2-dimethylcyclopropyl)carbonyl]amino]hept-2-enoat Eigenschaften
- Schmelzpunkt:
- >160°C (dec.)
- Flammpunkt:
- 87℃
- storage temp.
- 2-8°C
- Löslichkeit
- Very soluble in water and in methanol, slightly soluble in anhydrous ethanol, very slightly soluble in dimethyl sulfoxide, practically insoluble in acetone and in methylene chloride.
- Aggregatzustand
- Solid
- pka
- pKa1 2.0; pKa2 4.4; pKa3 9.2(at 25℃)
- Farbe
- White
- Biologische Quelle
- synthetic (organic)
- Wasserlöslichkeit
- water: 10mg/mL, clear, colorless to faintly yellow
- Stabilität:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
- InChIKey
- QXPBTTUOVWMPJN-LZTDVXLXNA-M
- SMILES
- [C@H]1(C(=O)N/C(=C\CCCCSC[C@H](N)C(O)=O)/C(=O)[O-])CC1(C)C.[Na+] |&1:0,12,r|
- CAS Datenbank
- 81129-83-1(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| WGK Germany |
WGK 3 |
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| RTECS-Nr. |
MJ9650200 |
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| HS Code |
2941.90.1050 |
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| Speicherklasse |
11 - Combustible Solids |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
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P264, P280, P305+P351+P338,P337+P313P |
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| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen. |
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Natriumhydrogen-[R-[R*,S*-(Z)]]-7-[(2-amino-2-carboxylatoethyl)thio]-2-[[(2,2-dimethylcyclopropyl)carbonyl]amino]hept-2-enoat Chemische Eigenschaften,Einsatz,Produktion Methoden
Chemische Eigenschaften
White or light yellow amorphous, hygroscopic powder.
Verwenden
Cilastatin sodium is a dipeptidase inhibitor with nephroprotective effects.
Definition
ChEBI: The monosodium salt of cilastatin. It is an inhibitor of dehydropeptidase I (membrane dipeptidase, 3.4.13.19), an enzyme found in the brush border of renal tubes and responsible for degrading the antibiotic imipenem. Cilastatin sodium is therefore administ
red with imipenem to prolong the antibacterial effect of the latter by preventing its renal metabolism to microbiologically inactive and potentially nephrotoxic products.
Allgemeine Beschreibung
Cilastatin sodium salt is off-white to yellowish-white, hygroscopic, amorphous compound. It is derivatized from heptenoic acid. Its molecular mass is 380.43 g.
Biologische Aktivität
Dipeptidase inhibitor (LTDase, leukotriene D4 hydrolase, dehydropeptidase I) that displays a K i value of 0.11 μ M. Inhibits metabolism of LTD 4 to LTE 4 and the hydrolysis of β -lactam antibiotics. Nephroprotective; reduces toxic accumulation of cyclosporin A in kidney proximal tubule epithelial cells.
Natriumhydrogen-[R-[R*,S*-(Z)]]-7-[(2-amino-2-carboxylatoethyl)thio]-2-[[(2,2-dimethylcyclopropyl)carbonyl]amino]hept-2-enoat Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Natriumhydrogen-[R-[R*,S*-(Z)]]-7-[(2-amino-2-carboxylatoethyl)thio]-2-[[(2,2-dimethylcyclopropyl)carbonyl]amino]hept-2-enoat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 232)Lieferanten
81129-83-1(Natriumhydrogen-[R-[R*,S*-(Z)]]-7-[(2-amino-2-carboxylatoethyl)thio]-2-[[(2,2-dimethylcyclopropyl)carbonyl]amino]hept-2-enoat)Verwandte Suche:
- 2-heptenoicacid,7-((2-amino-2-carboxyethyl)thio)-2-(((2,2-dimethylcyclopropyl
- l642957
- monosodiumsalt,(r-(r*,s*(z)))-)carbonyl)amino)
- sodium hydrogen [R-[R*,S*-(Z)]]-7-[(2-amino-2-carboxylatoethyl)thio]-2-[[(2,2-dimethylcyclopropyl)carbonyl]amino]hept-2-enoate
- Cilastatin sodium
- Sodium 7-(2-amino-2-carboxy-ethyl)sulfanyl-2-(2,2-dimethylcyclopropyl)carbonylamino-hept-2-enoate
- Sodium hydrogen 7-[(2-amino-2-carboxylatoethyl)thio]-2-[[(2,2-dimethylcyclopropyl)carbonyl]amino]hept-2-enoate
- Sodium Cilastatin
- [R-[R*,S*-(Z)]]-7-[(2-Amino-2-carboxyethyl)thio]-2-[[(2,2-dimethylcyclopropyl)carbonyl]amino]-2-heptenoic acid monosodium salt
- (Z)-7-[(R)-2-Amino-2-carboxyethylthio]-2-[(S)-2,2-dimethylcyclopropylcarbonylamino]-2-heptenoic acid 1-sodium salt
- (2Z)-7-[[(2R)-2-Amino-2-carboxyethyl]thio]-2-[[[(1S)-2,2-dimethylcyclopropyl]carbonyl]amino]-2-heptenoicacidsodiumsalt
- 2-Heptenoicacid,7-[[(2R)-2-aMino-2-carboxyethyl]thio]-2-[[[(1S)-2,2-diMethylcyclopropyl]carbonyl]aMino]-,sodiuM salt (1:1), (2Z)-
- Cilastatin sodium Ready Made Solution
- Cilastatin Impurity 9
- Cilastatin sodium CRS
- Cilastatin for system suitability 2 CRS
- Cilastatin for system suitability 1 CRS
- sodium (Z)-7-(((R)-2-amino-2-carboxyethyl)thio)-2-((S)-2,2-dimethylcyclopropanecarboxamido)hept-2-enoate
- (R)-2-Amino-3-[[(Z)-6-carboxy-6-[(S)-2,2-dimethylcyclopropanecarboxamido]hex-5-en-1-yl]thio]propanoic Acid Monosodium Salt
- Monosodium (R)-2-Amino-3-[[(Z)-6-carboxy-6-[(S)-2,2-dimethylcyclopropanecarboxamido]hex-5-en-1-yl]thio]propanoate
- Sodium (Z)-7-(((R)-2-amino-2-carboxyethyl)thio)-2-((S)-2,2-dimethylcyclopropane-1-carboxamido)hept-2-enoate
- Cilastatin sodium (C2170000)
- Sod i um (Z)-7-[[(2R)-2-a mi no-2-c a rb oxye th yl]sulf a nyl]-2-[[[(1S)-2,2-d i me th ylc yc lopropyl]c a rb onyl]a mi no]h e pt-2-e noa te
- 13C3,2H3,15N]-Cilastatin sodium
- Cilastatin Sodium, dehydrodipeptidase I inhibitor
- Cilastatin sodium salt - Bio-X ?
- Cilastatin sodium 100 μg/mL in Water
- (Z)-(R)-7-((2-amino-2-formylethyl)thioyl)-2-((S)-2,2-dimethylcyclopropyl)carboxamideyl)heptyl-2-eneacidsalt
- Cilastatine
- 81129-83-1
- C16H25N2NaO5S
- C16H26N2NaO5S
- Miscellaneous Enzyme
- APIs
