Dichlorobis(?5-cyclopenta-2,4-dien-1-yl)vanadium Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R25:Giftig beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S28:Bei Berührung mit der Haut sofort abwaschen mit viel . . . (vom Hersteller anzugeben).
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Chemische Eigenschaften
dark green crystalline powder
Verwenden
Vanadocene dichloride is used like other metallocenes as a
catalyst, ultraviolet absorber, reducing agent, free radical
scavenger, antiknock agent in gasoline, and as a developmental
anticancer drug.
Allgemeine Beschreibung
Pale green crystals or green powder.
Air & Water Reaktionen
Extremely sensitive to exposure to air. Also extremely sensitive to moisture; decomposes in water
Reaktivität anzeigen
Organometallics, such as BIS(CYCLOPENTADIENYL)VANADIUM DICHLORIDE, are reactive with many other groups. Incompatible with acids and bases. Organometallics are good reducing agents and therefore incompatible with oxidizing agents. Often reactive with water to generate toxic or flammable gases. Organometallics containing halogens (fluorine, chlorine, bromine, iodine) bonded to the metal typically with generate gaseous hydrohalic acids (HF, HCl, HBr, HI) with water.
Brandgefahr
Flash point data for BIS(CYCLOPENTADIENYL)VANADIUM DICHLORIDE are not available. BIS(CYCLOPENTADIENYL)VANADIUM DICHLORIDE is probably combustible.
Pharmazeutische Anwendungen
Vanadocene dichloride [( η
5-C
5H
5)
2VCl
2, dichloro bis(η
5-cyclopentadienyl)vanadium(IV)] is structurally very similar to Cp
2TiCl
2. It also consists of a metal centre with an oxidation number of +IV, in this case vanadium, and two Cp and two chloride ligands. Vanadocene dichloride is a 17-electron complex containing an unpaired electron and is therefore paramagnetic .
Vanadocene dichloride has found application as a catalyst for polymerisation reactions, but was also intensively studied as an anticancer agent in parallel to Cp
2TiCl
2 because of their structural similarities. Vanadocene dichloride has proven to be even more effective than its titanium analogue as an antiproliferative agent against both animal and human cell lines in preclinical testing. The main problems are the difficult characterisation of the active vanadium compounds and their fast hydrolysis.
Dichlorobis(?5-cyclopenta-2,4-dien-1-yl)vanadium Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
