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1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE

1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE Struktur
117690-79-6
CAS-Nr.
117690-79-6
Englisch Name:
1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE
Synonyma:
LY 255283;CGS 23356;LY255283 ，S2959;LY255283, 10 mM in DMSO;LY255283, BLT2 receptor antagonist;5'-Ethyl-2'-hydroxy-4'-[6-methyl-6-(1H-tetrazol-5-yl)heptyloxy]acetophenone;1-[5-ethyl-2-hydroxy-4-[6-methyl-6-(2H-tetrazol-5-yl)heptoxy]phenyl]ethanone;1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE;1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOLE-5-YL)HEPTYL]OXY]PHENYL]-ETHANONE;parcnchyma,LTB4,Leukotriene Receptor,inhibit,BLT2,LY255283,lung,Inhibitor,LY-255283
CBNumber:
CB9257308
Summenformel:
C19H28N4O3
Molgewicht:
360.45
MOL-Datei:
117690-79-6.mol
Request For Quotation

1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE Eigenschaften

Schmelzpunkt:
160-162 °C
Siedepunkt:
573.4±60.0 °C(Predicted)
Dichte
1.157±0.06 g/cm3(Predicted)
storage temp. 
Store at +4°C
Löslichkeit
DMSO: >20mg/mL
pka
5.11±0.10(Predicted)
Aggregatzustand
powder
Farbe
off-white to light yellow
InChI
1S/C19H28N4O3/c1-5-14-11-15(13(2)24)16(25)12-17(14)26-10-8-6-7-9-19(3,4)18-20-22-23-21-18/h11-12,25H,5-10H2,1-4H3,(H,20,21,22,23)
InChIKey
WCGXJPFHTHQNJL-UHFFFAOYSA-N
SMILES
CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c2nnn[nH]2

Sicherheit

WGK Germany  2
Speicherklasse 11 - Combustible Solids

1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Antagonists of the chemotactic and inflammatory lipoxygenase product leukotriene B4 (LTB4) have been potential drug development targets for several years. The tetrazole LY255283 is a competitive antagonist of the BLT2 receptor. It displaces radiolabeled LTB4 from guinea pig lung membrane, with an IC50 of about 100 nM. LY255283 exhibits IC50 values of ~950 nM and >10 μM at human recombinant BLT2 and BLT1 receptors, respectively. LY255283 inhibits eosinophil chemotaxis by 80% at a concentration of 10 μM, and inhibits the binding of radiolabeled LTB4 to eosinophil membranes with an IC50 of 260 nM.

Verwenden

LY-255283 is a selective, competitive BLT2 receptor antagonist used in the treatment of chronic myeloid leukemia.

Biologische Aktivität

Selective, competitive antagonist of BLT 2 receptors (IC 50 values are ~ 1 and > 10 μ M at human recombinant BLT 2 and BLT 1 receptors respectively). Inhibits LTB 4 -induced contraction of lung parenchyma (pA 2 = 7.2), and reduces LTB 4 -mediated airway obstruction in guinea pigs following i.v. and oral administration.

1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 82)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Alchem Pharmtech,Inc. 		8485655694
sales@alchempharmtech.com United States 63645 58
TargetMol Chemicals Inc. 		+1-781-999-5354; +1-00000000000
 marketing@targetmol.com United States 32431 58
Nantong HI-FUTURE Biology Co., Ltd. 		+86-18051384581
 sales@chemhifuture.com China 3123 58
Aladdin Scientific
tp@aladdinsci.com United States 54746 58
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037
 3bsc@sina.com China 15813 69
BOC Sciences 1-631-485-4226; 16314854226
 info@bocsci.com United States 9920 65
Guangzhou Isun Pharmaceutical Co., Ltd 020-39119399 18927568969
 isunpharm@qq.com China 4773 55
LETOPHARM LIMITED +86-21-5821 5861
sales@letopharm.com China 2374 58
SPIRO PHARMA
eric_feng1954@126.com China 9239 55
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627
 info@efebio.com China 9799 58

117690-79-6()Verwandte Suche:

Sulproston Fluprostenol
  • LY 255283
  • 1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE
  • 1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOLE-5-YL)HEPTYL]OXY]PHENYL]-ETHANONE
  • 5'-Ethyl-2'-hydroxy-4'-[6-methyl-6-(1H-tetrazol-5-yl)heptyloxy]acetophenone
  • CGS 23356
  • 1-[5-ethyl-2-hydroxy-4-[6-methyl-6-(2H-tetrazol-5-yl)heptoxy]phenyl]ethanone
  • Ethanone, 1-[5-ethyl-2-hydroxy-4-[[6-methyl-6-(2H-tetrazol-5-yl)heptyl]oxy]phenyl]-
  • 1-(5-Ethyl-2-hydroxy-4-((6-methyl-6-(2H-tetrazol-5-yl)heptyl)oxy)phenyl)ethan-1-one
  • parcnchyma,LTB4,Leukotriene Receptor,inhibit,BLT2,LY255283,lung,Inhibitor,LY-255283
  • LY255283, BLT2 receptor antagonist
  • LY255283, 10 mM in DMSO
  • LY255283 ，S2959
  • 117690-79-6
  • C19H28N4O3
  • Prostanoid receptor and related
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