Butoconazole nitrate
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- CAS-Nr.
- 64872-77-1
- Englisch Name:
- Butoconazole nitrate
- Synonyma:
- Gynomy;exelgyn;femstat;gynomyk;rs-35887;Buconazole nitrate;Butocozole nitrate;BUTOCONAZOLENITRILE;BUTACONAZOLE NITRATE;BUTOCONAZOLE NITRATE
- CBNumber:
- CB9706745
- Summenformel:
- C19H18Cl3N3O3S
- Molgewicht:
- 474.79
- MOL-Datei:
- 64872-77-1.mol
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Butoconazole nitrate Eigenschaften
- Schmelzpunkt:
- 159°C (dec.)
- storage temp.
- Sealed in dry,2-8°C
- Löslichkeit
- DMSO or DMF: soluble
- Aggregatzustand
- powder
- Farbe
- White to Off-White
- Merck
- 14,1529
- InChI
- InChI=1S/C19H17Cl3N2S.HNO3/c20-15-7-4-14(5-8-15)6-9-16(12-24-11-10-23-13-24)25-19-17(21)2-1-3-18(19)22;2-1(3)4/h1-5,7-8,10-11,13,16H,6,9,12H2;(H,2,3,4)
- InChIKey
- ZHPWRQIPPNZNML-UHFFFAOYSA-N
- SMILES
- C(CN1C=NC=C1)(SC1C(Cl)=CC=CC=1Cl)CCC1=CC=C(Cl)C=C1.[N+]([O-])(=O)O
- CAS Datenbank
- 64872-77-1(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Kennzeichnung gefährlicher |
Xn |
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| R-Sätze: |
22 |
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| WGK Germany |
3 |
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| RTECS-Nr. |
NI4399500 |
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| HS Code |
2933290000 |
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| Speicherklasse |
11 - Combustible Solids |
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| Hazard Classifications |
Acute Tox. 4 Oral |
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| Toxizität |
LD50 in mice, male, female rats (mg/kg): >3200, >3200, 1720 orally; >1600, 940, 940 i.p. (Walker) |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitsschädlich bei Verschlucken. |
Akute Toxizität oral |
Kategorie 4 |
Warnung |
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P264, P270, P301+P312, P330, P501 |
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Butoconazole nitrate Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Butoconazole Nitrate is the nitrate salt form of butaconazole, a synthetic imidazole derivative with fungistatic properties. Butoconazole is an imidazole antifungal agent that completely inhibits the growth of various fungi in vitro when used at concentrations of 0.05-30 μg/ml. It is active against vaginal infections of pure and mixed strains of C. albicans in mice when used vaginally at concentrations of 0.25-2% and 0.1-1%, respectively. Formulations containing butoconazole have been used in the treatment of vaginal yeast infections. Butoconazole Nitrate is an antifungal imidazole antimycotics. It is useful in the topical treatment of vulvovaginal candidiasis, being similar in effectiveness to miconazole and clotrimazole.
Chemische Eigenschaften
Butoconazole nitrate is a white to off-white crystalline powder with a molecular weight of 474.79. It is sparingly soluble in methanol, slightly soluble in chloroform, methylene chloride, acetone, and ethanol, very slightly soluble in ethyl acetate, and practically insoluble in water. It melts at about 159°C with decomposition.
Verwenden
Imidazole derivative with antifungal properties
Definition
ChEBI: An organic nitrate salt obtained by reaction of equimolar amounts of butaconazole and nitric acid. An antifungal agent, it is used in gynaecology for treatment of vulvovaginal infections caused by Candida species, particularly Candida a
bicans.
Clinical Use
1-[4-(4-Chlorophenyl)-2-[(2,6-dichlorophenyl)-thio]butyl]-1H-imidazole (Femstat) is an extremely broad-spectrum antifungaldrug that is specifically effective against C. albicans.It is supplied as a vaginal cream containing 2% of thesalt. It is intended for the treatment of vaginal candidiasis.
Butoconazole nitrate Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Butoconazole nitrate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 293)Lieferanten
64872-77-1()Verwandte Suche:
- (+-)-1-(4-(4-chlorophenyl)-2-((2,6-dichlorophenyl)thio)butyl)-1h-imidazolem
- 1-(4-(4-chlorophenyl)-2-((2,6-dichlorophenyl)thio)butyl)-1h-imidazol(+-)-1h-imidazol
- exelgyn
- Butoconazole nitrate
1-[4-(4-Chlorophenyl)-2-(2,6-dichlorophenyl)sulfanyl-butyl]imidazole nitrate
- 1-[4-(4-chlorophenyl)-2-[(2,6-dichlorophenyl)thio]butyl]imidazole
- (+-)-1-(4-(p-Chlorophenyl)-2-(
- 1-(4-(4-Chlorophenyl)-2-(2,6-dichlorophenylthio)-n-butyl)imidazole nitrate
- 1-[4-(4-chlorophenyl)-2-(2,6-dichlorophenyl)sulfanyl-butyl]imidazole nitrate
- BUTOCONAZOLE NITRATE
- BUTACONAZOLE NITRATE
- 1-[4-(4-Chlorophenyl)-2-[(2,6-dichlorophenyl)thio]butyl]-1H-imidazole Nitrate
- Gynomy
- BUTOCONAZOLENITRILE
- femstat
- gynomyk
- rs-35887
- BUTOCONAZOLE NITRATE USP(CRM STANDARD)
- Butoconazole Nitrate (200 mg)
- 1-[(2R)-4-(4-chlorophenyl)-2-[(2,6-dichlorophenyl)sulfanyl]butyl]-1H-iMidazole
- 1-[4-(4-chlorophenyl)-2-[(2,6-dichlorophenyl)thio]butyl]-1H-imidazole,nitrate (1:1)
- Butoconazole Nitrate >
- 1-[4-(4-Chlorophenyl)-2-[(2,6-dichlorophenyl)thio]butyl]imidazole Nitrate
- Butoconazole nitrate USP/EP/BP
- BOTOCONAZOLE NITRATE
- Butoconazole Nitrate (1082300)
- Buconazole nitrate
- Butoconazole Nitrate (RS35887)
- Butoconazole nitrate, 10 mM in DMSO
- Butocozole nitrate
- 64872-77-1
- 65872-77-1
- C19H18Cl3N3O3S
- C19H17Cl3N2SHNO3
- Intermediates & Fine Chemicals
- Pharmaceuticals
- API
