Nicergolin
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- CAS-Nr.
- 27848-84-6
- Bezeichnung:
- Nicergolin
- Englisch Name:
- Nicergoline
- Synonyma:
- nicergolin;10-Methoxy-1,6-dimethylergoline-8β-methanol 5-bromonicotinate;mne;Memoq;fi6714;TA 079;Ergobel;CS-1354;Ergotop;Sermion
- CBNumber:
- CB9728301
- Summenformel:
- C24H26BrN3O3
- Molgewicht:
- 484.39
- MOL-Datei:
- 27848-84-6.mol
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Nicergolin Eigenschaften
- Schmelzpunkt:
- 136-138°
- Siedepunkt:
- 594.4±50.0 °C(Predicted)
- Dichte
- 1.3558 (rough estimate)
- Brechungsindex
- 1.6200 (estimate)
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- Löslichkeit
- Practically insoluble in water, freely soluble in methylene chloride, soluble in ethanol (96 per cent).
- pka
- 6.33±0.40(Predicted)
- Aggregatzustand
- Solid
- Farbe
- White to Off-White
- Wasserlöslichkeit
- Soluble in alcohol, chloroform, and acetone. Insoluble in water.
- Merck
- 14,9496
- Major Application
- forensics and toxicology
pharmaceutical (small molecule)
veterinary
- InChIKey
- YSEXMKHXIOCEJA-AQDCORRGNA-N
- SMILES
- O([C@]12C[C@@H](COC(C3=CN=CC(Br)=C3)=O)CN(C)[C@]1([H])CC1=CN(C)C3=CC=CC2=C13)C |&1:1,3,18,r|
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Kennzeichnung gefährlicher |
Xn |
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| R-Sätze: |
22 |
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| S-Sätze: |
36 |
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| RIDADR |
1544 |
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| WGK Germany |
3 |
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| RTECS-Nr. |
KE6341000 |
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| HazardClass |
6.1(b) |
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| PackingGroup |
III |
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| HS Code |
29396100 |
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| Speicherklasse |
11 - Combustible Solids |
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| Hazard Classifications |
Acute Tox. 4 Oral |
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| Toxizität |
LD50 in male mice, rats (mg/kg): 860, 2800 orally; 46, 43 i.v. (Neumann, Lauschner) |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitsschädlich bei Verschlucken. |
Akute Toxizität oral |
Kategorie 4 |
Warnung |
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P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
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Nicergolin Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
S-Sätze Betriebsanweisung:
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
Fine to granular, white or yellowish powder.
Verwenden
Nicergoline is a drug used for age-dependent cognitive impairment such as Alzheimers disease and other types of dementia. Nicergoline has shown to protect cultured neurons against β-amyloid toxicity. Nicergoline protects against neuronal cell death induced by activated microglia and astrocytes through the inhibition of inflammatory mediators and the upregulation of neurotrophic factors by glial cells. Nicergoline is a drug used for age-dependent cognitive impairment and it protects cultured neurons against β-amyloid toxicity.
Biologische Aktivität
α -adrenergic, vasodilator. Cognitive enhancer.
Sicherheitsprofil
Poison by intravenous
route. Moderately toxic by ingestion and
subcutaneous routes. An experimental
teratogen. Other experimental reproductive
effects. A vasodilator. When heated to
decomposition it emits very toxic fumes of
Brand NOx.
Nicergolin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Nicergolin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 429)Lieferanten
27848-84-6(Nicergolin)Verwandte Suche:
- nicergoline Fr.P
- Ergoline-8-methanol, 10-methoxy-1,6-dimethyl-, 5-bromo-3-pyridinecarboxylate (ester), (8.beta.)-
- 1,6-Dimethyl-8b-(5-bromonicotinoyloxymethyl)-10a-methoxyergoline
- Cergodum
- Circo-Maren
- Dilasenil
- Duracebrol
- Ergobel
- Ergoline-8b-methanol, 10-methoxy-1,6-dimethyl-, 5-bromonicotinate (ester) (8CI)
- Ergoline-8-methanol, 10-methoxy-1,6-dimethyl-, 5-bromo-3-pyridinecarboxylate (ester), (8b)- (9CI)
- 5-BROMONICOTINIC ACID 10-METHOXY-1,6-DIMETHYLERGOLINE-8-METHANOL ESTER
- 5-BROMONICOTINIC ACID 10-METHOXY-1,6-DIMETHYLERGOLINE-8-METHYL ESTER
- (8BETA)-10-METHOXY-1,6-DIMETHYLERGOLINE-8-METHANOL 5-BROMO-3-PYRIDINE CARBOXYLATE ESTER
- (+)-10-methoxy-1,6-dimethylergoline-8-beta-methanol5-bromonicotinate
- 10-methoxy-1,6-dimethyl-ergolin-8-beta-methanol-(5-bromnicotinat)
- 10-methoxy-1,6-dimethyl-ergoline-8-beta-methano5-bromo-3-pyridinecarboxy
- 10-methoxy-1,6-dimethyl-ergoline-8-beta-methano5-bromonicotinate(ester)
- 10-methoxy-1,6-dimethylergoline-8-methanol5-bromo-3-pyrindinecarboxylate(es
- 1-methyl-lumilysergol8-(5-bromonicotinate)10-methylether
- 8-beta-((5-bromonicotinoyloxy)methyl)-1,6-dimethyl-10-alpha-methoxyergoline
- fi6714
- late(ester)
- mne
- nargoline
- nicotergoline
- nimergoline
- NICERGOLINE
- Nicergoline powder
- CS-1354
- Nicergoline, Sermion
- API-Nicergoline
- Ergotop
- Indolo[4,3-fg]quinoline, ergoline-8-methanol deriv.
- Memoq
- Nicotinic acid, 5-bromo-, (10-methoxy-1,6-dimethylergolin-8b-yl)methyl ester (8CI)
- NSC 150531
- Sermion
- TA 079
- (8β)-10-methoxy-1,6-dimethylergoline-8-methanol5-bromo-3-pyridinecarboxylateester
- 10a-Methoxy-9,10-dihydrolyzergol (MDL)
- 1-Methyl-10a-Methoxy-9,10-dihydrolyzergol (1-MMDL)
- [(8R,10S)-10-Methoxy-1,6-dimethylergolin-8-yl]methyl 5-Bromopyridine-3-carboxylate
5-Bromopyridine-3-carboxylic Acid [(8R,10S)-10-Methoxy-1,6-dimethylergolin-8-yl]methyl Ester
- ((6aR,9R,10aS)-10a-Methoxy-4,7-diMethyl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinolin-9-yl)Methyl 5-broMonicotinate
- Ergoline-8-Methanol,10-Methoxy-1,6-diMethyl-, 8-(5-broMo-3-pyridinecarboxylate), (8b)-
- Nicergoline for system suitability
- Nicergoline for peak identification
- Nicergoline CRS
- Nicergoline for peak identification CRS
- Nicergoline>
- Nicergoline for system suitability CRS
- Nicergolinum
- Ergoline-8-methanol, 10-methoxy-1,6-dimethyl-, 8-(5-bromo-3-pyridinecarboxylate), (8β)-
- Ergoline-8-methanol, 10-methoxy-1,6-dimethyl-,5-bromo-3-pyridinecarboxylate (ester), (8b)-
- Nicergoline impurity
- ((6aR,9R,10aS)-10a-methoxy-4,7-dimethyl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinolin-9-yl)methyl 5-chloronicotinate
- (2S,4R,7R)-2-methoxy-6,11-dimethyl-6,11-diazatetracyclo[7.6.1.0^{2,7}.0^{12,16}]hexadeca-1(16),9,12,14-tetraen-4-yl]methyl 5-bromopyridine-3-carboxylate
- [(8R,10S)-10-Methoxy-1,6-dimethylergolin-8-yl]methyl 5-Bromopyridine-3-carboxylate
- 5-Bromopyridine-3-carboxylic Acid [(8R,10S)-10-Methoxy-1,6-dimethylergolin-8-yl]methyl Ester
