2-Amino-5-Methylthiopyridine
- CAS No.
- 77618-99-6
- Chemical Name:
- 2-Amino-5-Methylthiopyridine
- Synonyms
- 2-Amino-5-(methylthio);2-Amino-5-Methylthiopyridine;2-Pyridinamine, 5-(methylthio)-;5-methylsulfanylpyridin-2-amine;2-AMino-5-Methylsulfanylpyridine;5-(Methylsulfanyl)-2-pyridinamine
- CBNumber:
- CB01013786
- Molecular Formula:
- C6H8N2S
- Molecular Weight:
- 140.21
- MDL Number:
- MOL File:
- 77618-99-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 65.5-66.5 °C(Solv: ethyl ether (60-29-7)) |
|---|---|
| Boiling point | 295.9±20.0 °C(Predicted) |
| Density | 1.20±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| pka | 5.52±0.13(Predicted) |
| Appearance | Light yellow to yellow Solid |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H332-H319-H335-H315-H312-H302 |
| Precautionary statements | P261-P271-P304+P340-P312-P264-P270-P301+P312-P330-P501-P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362-P280-P302+P352-P312-P322-P363-P501 |
2-Amino-5-Methylthiopyridine price More Price(32)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| AstaTech | 51047 | 2-AMINO-5-METHYLSULFANYLPYRIDINE 97% | 77618-99-6 | 0.25G | $69 | 2026-04-30 | Buy |
| AstaTech | 51047 | 2-AMINO-5-METHYLSULFANYLPYRIDINE 97% | 77618-99-6 | 1G | $224 | 2026-04-30 | Buy |
| AstaTech | 51047 | 2-AMINO-5-METHYLSULFANYLPYRIDINE 97% | 77618-99-6 | 5G | $847 | 2026-04-30 | Buy |
| Biosynth | CDA61899 | 2-Amino-5-(methylthio)pyridine | 77618-99-6 | 0.5g | $424.8 | 2026-06-04 | Buy |
| Biosynth | CDA61899 | 2-Amino-5-(methylthio)pyridine | 77618-99-6 | 5g | $1888 | 2026-06-04 | Buy |
2-Amino-5-Methylthiopyridine Chemical Properties, Uses, Production
Synthesis
35196-09-9
77618-99-6
The general procedure for the synthesis of 2-amino-5-(methylthio)pyridine from 5-(methylthio)-2-nitropyridine was as follows: 5-(methylthio)-2-nitropyridine (300 mg, 1.8 mmol) was dissolved in a mixed solvent of acetic acid (7 mL) and concentrated hydrochloric acid. Concentrated hydrochloric acid (0.5 mL) and zinc powder (692 mg, 10.6 mmol) were slowly added to the reaction system in batches under ice bath cooling for 5 min. Subsequently, the reaction mixture was stirred at room temperature for 30 min. Upon completion of the reaction, the insoluble material was removed by filtration, and the filtrate was neutralized with aqueous sodium bicarbonate to neutral and extracted with dichloromethane. The organic layers were combined, washed sequentially with water and saturated aqueous sodium chloride, and dried over anhydrous sodium sulfate. The solvent was removed by distillation under reduced pressure, and the crude product obtained was purified by silica gel column chromatography (elution gradient: hexane/ethyl acetate=1:1→chloroform/methanol=20:1), and finally 158 mg of 2-amino-5-(methylthio)pyridine (Yield 64%) was obtained as a light-yellow powdery crystal.
References
[1] Patent: US6849647, 2005, B1. Location in patent: Page/Page column 145
[2] Patent: US2002/52349, 2002, A1
[3] Patent: US2013/225638, 2013, A1. Location in patent: Paragraph 0282; 0284
2-Amino-5-Methylthiopyridine Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
2-Amino-5-Methylthiopyridine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai civi chemical technology co.,Ltd | 86-21-34053660 | sale@labgogo.com | China | 9853 | 52 |
| Shanghai Jian Chao Chemical Technology Co., Ltd. | 150-2103-5486 18017383231 | 983544897@qq.com | China | 9335 | 55 |
| SynAsst Chemical. | 021-60343070 | China | 12731 | 55 | |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Shanghai Worldyang Chemical Co.,Ltd. | 021-56795766 | sales@worldyachem.com | China | 9475 | 58 |
| Shanghai Aspire Biological Technology Co., Ltd. | 021-61317773 | sales@aspirebio.com | China | 2880 | 58 |
| Hotechem Shanghai Co., Ltd., | 021-34621078 13120882795 | 465106944@qq.com | China | 859 | 56 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Wuxi AppTec | 022-59987777 13552403979 | jia_guoqiang@wuxiapptec.com | China | 22344 | 58 |
| Aikon International Limited | 025-66061636 19370895928 | qqyang@aikonchem.com | China | 15810 | 58 |
