Benzothiazole, 2-chloro-4-methoxy- (6CI,7CI,8CI,9CI)
- CAS No.
- 3507-27-5
- Chemical Name:
- Benzothiazole, 2-chloro-4-methoxy- (6CI,7CI,8CI,9CI)
- Synonyms
- 12944-A3;2-chloro-4-methoxybenzothiazle;2-chloro-4-methoxybenzo[d]thiazole;Benzothiazole, 2-chloro-4-Methoxy-;2-chloro-4-methoxy-1,3-benzothiazole - [C71580];Benzothiazole, 2-chloro-4-methoxy- (6CI,7CI,8CI,9CI)
- CBNumber:
- CB01041701
- Molecular Formula:
- C8H6ClNOS
- Molecular Weight:
- 199.66
- MDL Number:
- MFCD04448819
- MOL File:
- 3507-27-5.mol
- MSDS File:
- SDS
| Melting point | 66 °C |
|---|---|
| Boiling point | 293.5±13.0 °C(Predicted) |
| Density | 1.404±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| pka | -0.08±0.10(Predicted) |
| Appearance | Off-white to light yellow Solid |
| InChI | InChI=1S/C8H6ClNOS/c1-11-5-3-2-4-6-7(5)10-8(9)12-6/h2-4H,1H3 |
| InChIKey | MCCTXJVKIFYBJV-UHFFFAOYSA-N |
| SMILES | S1C2=CC=CC(OC)=C2N=C1Cl |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 29342000 |
Benzothiazole, 2-chloro-4-methoxy- (6CI,7CI,8CI,9CI) price More Price(39)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR939266 | 2-Chloro-4-methoxybenzothiazole 95% | 3507-27-5 | 100mg | $30 | 2026-06-04 | Buy |
| Apolloscientific | OR939266 | 2-Chloro-4-methoxybenzothiazole 95% | 3507-27-5 | 250mg | $45 | 2026-06-04 | Buy |
| Apolloscientific | OR939266 | 2-Chloro-4-methoxybenzothiazole 95% | 3507-27-5 | 1g | $146 | 2026-06-04 | Buy |
| Apolloscientific | OR939266 | 2-Chloro-4-methoxybenzothiazole 95% | 3507-27-5 | 5g | $525 | 2026-06-04 | Buy |
| Matrix Scientific | 136177 | 2-Chloro-4-methoxy-benzothiazole | 3507-27-5 | 1.00g | $524 | 2026-05-18 | Buy |
Benzothiazole, 2-chloro-4-methoxy- (6CI,7CI,8CI,9CI) Chemical Properties, Uses, Production
Chemical Properties
Pale yellow liquid
Synthesis
5464-79-9
3507-27-5
The general procedure for the synthesis of 2-chloro-4-methoxybenzo[d]thiazole using 2-amino-4-methoxybenzothiazole as starting material was as follows: copper(II) chloride (3.36 g, 25.0 mmol), acetonitrile (71 mL), and isoamyl nitrite (2.2 mL, 16.6 mmol) were added to a 500 mL three-neck flask equipped with a condenser under nitrogen protection. The suspension was placed in a 65 °C oil bath and stirred for 10 min, followed by the slow addition of a solution of 2-amino-4-methoxybenzothiazole (2.00 g, 11.1 mmol) in acetonitrile (42 mL). The reaction mixture was stirred continuously in an oil bath at 65 °C for 2 h and subsequently cooled to 20 °C. Water (150 mL) and 1N hydrochloric acid (100 mL) were added to the reaction mixture, followed by extraction with ethyl acetate (3 x 100 mL). The organic layers were combined, washed with saturated brine, dried over anhydrous sodium sulfate, filtered and concentrated. The resulting residue was purified by silica gel column chromatography (5% to 15% gradient with ethyl acetate in hexane as eluent) to afford 2-chloro-4-methoxybenzo[d]thiazole (1.52 g, 69% yield) as a white solid.
References
[1] Patent: WO2016/197078, 2016, A1. Location in patent: Paragraph 626
[2] Gazzetta Chimica Italiana, 1964, vol. 94, p. 372 - 381
Benzothiazole, 2-chloro-4-methoxy- (6CI,7CI,8CI,9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Baiyin letianyuan chemical co., LTD | 0943-8627236 18194330484 | 2919219720@qq.com | China | 68 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Shanghai Longsheng chemical Co.,Ltd. | 58099637 13585536065 | sales@shlschem.com | China | 9880 | 59 |
| China DongFan Chemical Co.,LTD | 86-0571-85151182 | China | 5681 | 66 | |
| Jinan Trio PharmaTech Co., Ltd. | 0531-88811783 | sales@trio-pharmatech.com | China | 1856 | 62 |
| Shanghai Ennopharm Co., Ltd. | +86 (21) 6435-5022 | China | 4263 | 65 | |
| chenyue Chemicals Co., Ltd. | +86-0519-85500896 | benzoxazolone@163.com | China | 178 | 58 |
| Chiba Pharmaceutical Science and technology Co, Ltd. | 0531-81313138 13066006660 | chibapharm@foxmail.com | China | 3996 | 55 |
| SuZhou ShiYa Biopharmaceuticals, Inc. | 86(512)5235 8471 17715136450 | sales@shiyabiopharm.com | China | 4167 | 58 |
View Latest Price from Benzothiazole, 2-chloro-4-methoxy- (6CI,7CI,8CI,9CI) manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-07-11 | 2-Chloro-4-methoxy-benzothiazole
3507-27-5
|
$1.00 | 1Kg | 98% | 20T | Shaanxi Dideu Medichem Co. Ltd | |
 |
2019-08-29 | Benzothiazole, 2-chloro-4-methoxy- (6CI,7CI,8CI,9CI)
3507-27-5
|
$1.00-2.00 | 1KG | 95%-99% | 100kg | Career Henan Chemical Co |
-
- 2-Chloro-4-methoxy-benzothiazole
3507-27-5
- $1.00
- 98%
- Shaanxi Dideu Medichem Co. Ltd
-
- Benzothiazole, 2-chloro-4-methoxy- (6CI,7CI,8CI,9CI)
3507-27-5
- $1.00-2.00
- 95%-99%
- Career Henan Chemical Co
