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Quinazoline, 2-(1H-indol-4-yl)-4-[(3R)-3-methyl-4-morpholinyl]-6-(1-methyl-1H-pyrazol-5-yl)-

Quinazoline, 2-(1H-indol-4-yl)-4-[(3R)-3-methyl-4-morpholinyl]-6-(1-methyl-1H-pyrazol-5-yl)- structure

CAS No.: 2713577-16-1

Chemical Name:: Quinazoline, 2-(1H-indol-4-yl)-4-[(3R)-3-methyl-4-morpholinyl]-6-(1-methyl-1H-pyrazol-5-yl)-

Synonyms: Quinazoline, 2-(1H-indol-4-yl)-4-[(3R)-3-methyl-4-morpholinyl]-6-(1-methyl-1H-pyrazol-5-yl)-

CBNumber:: CB010619485

Molecular Formula:: C25H24N6O

Molecular Weight:: 424.5

MDL Number:

MOL File:: 2713577-16-1.mol

Last updated:2025-07-25 23:32:35

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Quinazoline, 2-(1H-indol-4-yl)-4-[(3R)-3-methyl-4-morpholinyl]-6-(1-methyl-1H-pyrazol-5-yl)- Properties

Boiling point	612.2±55.0 °C(Predicted)
Density	1.37±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
pka	15.61±0.30(Predicted)
form	Solid
color	White to light yellow

Quinazoline, 2-(1H-indol-4-yl)-4-[(3R)-3-methyl-4-morpholinyl]-6-(1-methyl-1H-pyrazol-5-yl)- Chemical Properties,Uses,Production

Uses

SKLB-197 showed an IC50 value of 0.013 μM against ATR but very weak or no activity against other 402 protein kinases. It displayed potent antitumor activity against ATM-deficent tumors both in vitro and in vivo.

Biological Activity

IC 50

ATR: 0.013 μM (IC₅₀)

References

[1]. Bin H,et al. Discovery of a potent and highly selective inhibitor of ataxia telangiectasia mutated and Rad3-Related (ATR) kinase: Structural activity relationship and antitumor activity both in vitro and in vivo. Eur J Med Chem. 2022 Feb 12;232:114187

Quinazoline, 2-(1H-indol-4-yl)-4-[(3R)-3-methyl-4-morpholinyl]-6-(1-methyl-1H-pyrazol-5-yl)- Preparation Products And Raw materials

Raw materials

Preparation Products

Quinazoline, 2-(1H-indol-4-yl)-4-[(3R)-3-methyl-4-morpholinyl]-6-(1-methyl-1H-pyrazol-5-yl)- Suppliers

Global( 15)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	sales@chemhifuture.com	China	3135	58
TargetMol Chemicals Inc.	+17819995354	marketing@targetmol.com	United States	19939	58
ShangHai Caerulum Pharma Discovery Co., Ltd.	18149758185	sales-cpd@caerulumpharma.com	China	3479	58
Changzhou Chenhong Biotechnology Co., Ltd.	0519-85788828 13775037613	sales@chemrenpharm.com	China	3907	58
Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd	15317229551	15151849396@163.com	China	997	58
Nantong Hi-Future Biotechnology Co., Ltd	18051384581	sales@chemhifuture.com	China	3210	58
InvivoChem	13549236410	sales@invivochem.cn	China	6753	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24985	58
Shanghai Yifei Biotechnology Co. , Ltd.	021-65675885 18964387627	customer_service@efebio.com	China	11973	58
RD International Technology Co., Limited	18024082417	market@ubiochem.com	China	9835	58

Supplier	Advantage
Nantong HI-FUTURE Biology Co., Ltd.	58
TargetMol Chemicals Inc.	58
ShangHai Caerulum Pharma Discovery Co., Ltd.	58
Changzhou Chenhong Biotechnology Co., Ltd.	58
Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd	58
Nantong Hi-Future Biotechnology Co., Ltd	58
InvivoChem	58
TargetMol Chemicals Inc.	58
Shanghai Yifei Biotechnology Co. , Ltd.	58
RD International Technology Co., Limited	58

View Lastest Price from Quinazoline, 2-(1H-indol-4-yl)-4-[(3R)-3-methyl-4-morpholinyl]-6-(1-methyl-1H-pyrazol-5-yl)- manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2025-07-25	SKLB-197 2713577-16-1	US $929.00-1490.00 / mg			10g	TargetMol Chemicals Inc.

SKLB-197
2713577-16-1
US $929.00-1490.00 / mg
TargetMol Chemicals Inc.

Quinazoline, 2-(1H-indol-4-yl)-4-[(3R)-3-methyl-4-morpholinyl]-6-(1-methyl-1H-pyrazol-5-yl)- 2713577-16-1