1H-Isoindole-1,3(2H)-dione, 4-[(5-aminopentyl)oxy]-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1)
![1H-Isoindole-1,3(2H)-dione, 4-[(5-aminopentyl)oxy]-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1) Structure](CAS/20211123/GIF/2419145-66-5.gif)
- CAS No.
- 2419145-66-5
- Chemical Name:
- 1H-Isoindole-1,3(2H)-dione, 4-[(5-aminopentyl)oxy]-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1)
- Synonyms
- Thalidomide-O-C5-NH2 (hydrochloride);Thalidomide-4-O-C5-NH2 (hydrochloride);1H-Isoindole-1,3(2H)-dione, 4-[(5-aminopentyl)oxy]-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1)
- CBNumber:
- CB010729609
- Molecular Formula:
- C18H22ClN3O5
- Molecular Weight:
- 395.84
- MDL Number:
- MOL File:
- 2419145-66-5.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Warning |
| Hazard statements | H361 |
| Precautionary statements | P501-P202-P201-P280-P308+P313-P405 |
1H-Isoindole-1,3(2H)-dione, 4-[(5-aminopentyl)oxy]-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1) price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0169510 | Thalidomide-4-O-C5-NH2 hydrochloride ≥96% | 2419145-66-5 | 100mg | $135 | 2026-06-04 | Buy |
| ChemScene | CS-0169510 | Thalidomide-4-O-C5-NH2 hydrochloride ≥96% | 2419145-66-5 | 250mg | $224 | 2026-06-04 | Buy |
| ChemScene | CS-0169510 | Thalidomide-4-O-C5-NH2 hydrochloride ≥96% | 2419145-66-5 | 1g | $971 | 2026-06-04 | Buy |
| BroadPharm | bp-44397 | Thalidomide-4-O-C5-NH2 hydrochloride | 2419145-66-5 | 50MG | $120 | 2026-05-24 | Buy |
| BroadPharm | bp-44397 | Thalidomide-4-O-C5-NH2 hydrochloride | 2419145-66-5 | 100MG | $220 | 2026-05-24 | Buy |
1H-Isoindole-1,3(2H)-dione, 4-[(5-aminopentyl)oxy]-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1) Chemical Properties, Uses, Production
Uses
Thalidomide-4-O-C5-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].
IC 50
Cereblon
References
[1] Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine.Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11. DOI:10.3389/fcell.2021.629326
[2] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. DOI:10.7554/eLife.57277
1H-Isoindole-1,3(2H)-dione, 4-[(5-aminopentyl)oxy]-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1) Preparation Products And Raw materials
Raw materials
Preparation Products
1H-Isoindole-1,3(2H)-dione, 4-[(5-aminopentyl)oxy]-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 13301690235 | Sales@ATKchemical.com | China | 9699 | 58 |
| Jilin Province Woda Biotechnology Co., Ltd. | 13504435624 | 1927928688@qq.com | China | 1644 | 58 |
| Nanjing Bestfluorodrug Pharmaceutical Technology CO.,LTD | 025-86755008 17751752005 | hszhang@bestfluorodrug.com | China | 2357 | 58 |
| Taizhou Nanfeng Pharmaceutical Research Institute | nanfengpharma@126.co 18616377689 | nanfengpharma@126.com | China | 20008 | 58 |
| Shanghai Haohong Pharmaceutical Co., Ltd. | 400-8210725 4008210725 | malulu@leyan.com | China | 54996 | 58 |
| Bide Pharmatech Ltd. | 400-1647117 13681763483 | product02@bidepharm.com | China | 59929 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Nanjing Bestfluorodrug Pharmaceutical Technology CO.,LTD | 025-86755008 17751752005 | hszhang@bestfluorodrug.com | China | 2873 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| Zhejiang Huida Biotech Co., Ltd. | 0571-89903022 18679456698 | zilong@hizyme.com | China | 7853 | 58 |
